Application of human iPS cell-derived intestinal epithelial cells as a novel prediction system for drug disposition and drug interaction
| Project/Area Number |
17K08421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
Iwao Takahiro 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 (50581740)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小腸 / 薬物動態 / iPS細胞 / ヒトiPS細胞 / 薬学 |
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| Outline of Final Research Achievements |
We were able to find some useful small molecule compounds in the differentiation of human iPS cells to intestinal epithelial cells in this study. It was indicated that the human iPS cell-derived intestinal epithelial cells had drug metabolizing enzyme activities, CYP3A4 inducibility, drug transporter activities, and barrier functions. In addition, it was suggested that the cells would be available as an evaluation system to predict intestinal drug absorption quantitatively.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、ヒトiPS細胞から作製した腸管上皮細胞が医薬品の消化管吸収を定量的に評価できる系としての有用性を示すことができた。現在、よりよい医薬品の消化管吸収予測系の開発が望まれていることから、本研究で得られた成果はこの分野において有用であると考えられる。
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Report
(4 results)
Research Products
(27 results)
