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Preparation and characterization of porous hydrogel for oral stomatitis caused by cancer chemotherapy.

Research Project

Project/Area Number 17K08466
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionTokyo University of Science

Principal Investigator

Hanawa Takehisa  東京理科大学, 薬学部薬学科, 教授 (00302571)

Co-Investigator(Kenkyū-buntansha) 河野 弥生  東京理科大学, 薬学部薬学科, 講師 (50711660)
廣木 章博  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 先端機能材料研究部, 主幹研究員(定常) (10370462)
田口 光正  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 先端機能材料研究部, 上席研究員(定常) (60343943)
佐藤 光利  明治薬科大学, 薬学部, 教授 (60231346)
本間 真人  筑波大学, 医学医療系, 教授 (90199589)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsハイドロゲル / 口腔粘膜炎 / 電子線照射 / 凍結融解法 / 粘膜付着 / ポリビニルアルコール / 付着性 / 創傷治癒 / ドレッシング材 / 多孔性 / 鋳型 / キセロゲル
Outline of Final Research Achievements

A hydrogel (gel) formulation for treating oral mucositis was prepared. The presence or absence of gel formation and physicochemical properties were examined by "freezing and thawing" or "electron beam irradiation" of an aqueous solution of polyvinyl alcohol (PVA), which is a water-soluble polymer. As a result, it was clarified that the gel prepared by the freeze-thaw method formed a gel having high strength as the concentration and the number of freeze-thaw cycles increased.
On the other hand, when the gel was prepared by the electron beam irradiation method, similar to the freeze-thaw method, the degree of swelling decreased with increasing concentration and the amount of electron beam irradiation, while a gel with higher strength was formed and freeze-thawed. It became clear that the method can be easily prepared without using a special device such as an electron beam irradiation device.

Academic Significance and Societal Importance of the Research Achievements

本方法は有機溶剤に架橋剤を溶解させる化学的架橋法と異なり、製剤中に有機溶媒が存在しない安全な口腔内用製剤を調製することができる点で製剤学的な意義は大きい。また、ハイドロゲルは内部に水分を含有するため、柔軟性に富み、口腔内の複雑な形状の患部にも貼付でき、患部から浸出液を排出する潰瘍性の口腔粘膜炎にも適用できる。口腔粘膜に適応するためには、粘膜付着性を有する物質で製剤を調製するのが一般的であるが、ゲルを構成する高分子の種類、濃度、電子線照射量を種々変化することにより、医薬品の放出、粘膜への滞留性が制御可能な、個々の患者の症状に合わせた製剤を調製する、製剤学的なテーラーメード医療が実現すると考える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (24 results)

All 2019 2018 2017

All Journal Article (11 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (12 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Development of Hospital Formulations Based on Medical Need2019

    • Author(s)
      河野弥生、花輪剛久
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 139 Issue: 10 Pages: 1275-1280

    • DOI

      10.1248/yakushi.19-00121-2

    • NAID

      130007721884

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2019-10-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gellan gum: A new member in the dysphagia thickener family2019

    • Author(s)
      Ophelie Torres, Ayuri Yamada, Neil M. Rigby, Takehisa Hanawa, Yayoi Kawano, Anwesha Sarkar
    • Journal Title

      Biotribology

      Volume: 17 Pages: 8-18

    • DOI

      10.1016/j.biotri.2019.02.002

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 内製剤の流れ-上流(医療ニーズ)上流から下流(臨床応用)-に大学はどう係われるのか? (4) 掲載誌名または プロシーディングス名2018

    • Author(s)
      花輪 剛久,百 賢二,河野 弥生,米持 悦生,山内 仁史
    • Journal Title

      AKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN138

      Volume: 138 Pages: 751-752

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acceleration of wound healing induced by hyaluronic acid2018

    • Author(s)
      Yayoi Kawano, Rihoko Kageyama, Takuya Iyoda, Fumio Fukai, Takehisa Hanawa
    • Journal Title

      New Biotechnology

      Volume: 14 Pages: 134-134

    • DOI

      10.1016/j.nbt.2018.05.990

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds2018

    • Author(s)
      Yayoi Kawano, Takehisa Hanawa, Rina Takahashi et al.
    • Journal Title

      EMBO Molecular Medicine

      Volume: 2018 Issue: 10 Pages: 1-21

    • DOI

      10.15252/emmm.201809024

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells2018

    • Author(s)
      Shoma Tamori, Yuka Nozaki, Hitomi Motomura, Hiromi Nakane, Reika Katayama, Chotaro Onaga, Eriko Kikuchi, Nami Shimada, Yuhei Suzuki, Mei Noike, Yasushi Hara, Keiko Sato, Tsugumichi Sato, Kouji Yamamoto, Takehisa Hanawa, Misa Imai, Ryo Abe, Atsushi Yoshimori, Ryoko Takasawa, Sei-Ichi Tanuma and Kazunori Akimoto
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 92 Pages: 36515-36529

    • DOI

      10.18632/oncotarget.26369

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] がん化学療法における副作用に対する「患者に優しい製剤」の開発2018

    • Author(s)
      花輪剛久、河野弥生
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 138 Pages: 169-176

    • NAID

      130006328033

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] フッ素樹脂コーティングガラスと医薬品の相互作用の検討2017

    • Author(s)
      河野弥生、大津早紀、花輪剛久
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Pages: 1409-1417

    • NAID

      130006191283

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preparation and Evaluation of Physicochemical Properties of Isosorbide Gel Composed of Xanthan Gum, Locust Bean Gum and Agar for Improving the Patient’s Adherence2017

    • Author(s)
      ayoi Kawano, Haruna Kiuchi, Tamami Haraguchi, Miyako Yoshida, Takahiro Uchida, Takehisa Hanawa
    • Journal Title

      International Journal of Medicine and Pharmacy

      Volume: 5 Pages: 18-32

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of a rebamipide mouthwash on stomatitis caused by cancer chemotherapy-Evaluation of the efficacy by patients themselves-2017

    • Author(s)
      石井直子、河野弥生、花輪剛久
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Pages: 1027-1034

    • NAID

      130005875818

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development and Characterization of a Suspension Containing Nanoparticulated Rebamipide for a Mouth Wash for Stomatitis2017

    • Author(s)
      Yayoi Kawano, Naoko Ishii, Yuichiro Shimizu and Takehisa Hanawa
    • Journal Title

      Journal of Pharmaceutical Science and Technology, Japan

      Volume: 77 Pages: 104-115

    • NAID

      130005402189

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Preparation and characterization of hydrogels by electron beam cross-linking2019

    • Author(s)
      Yayoi Kawano, , Kazumi Yoshizawa, Takehisa Hanawa
    • Organizer
      Forum for Nuclear Communbication in Asia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 尋常性ざ瘡に対するスピロノラクトンゲルの開発ーIn vitroにおける有効性の評価および基剤の特性を考慮した製剤処方の検討ー2019

    • Author(s)
      淺見真菜、吉川里香、河野弥生、花輪剛久、河野洋平、青山隆夫
    • Organizer
      日本薬学会 第139年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 創傷管理製品のユーザビリティーに関するニーズ探索2018

    • Author(s)
      茂野 奈穂子,河野 弥生,花輪 剛久
    • Organizer
      医療薬学フォーラム2018,第26回クリニカルファーマシーシンポジウム(東京)
    • Related Report
      2018 Research-status Report
  • [Presentation] ヒアルロン酸を含有する創傷治療用外用剤の開発2018

    • Author(s)
      河野 弥生,影山 理芳子,花輪 剛久
    • Organizer
      医療薬学フォーラム2018, 第26回クリニカルファーマシーシンポジウム(東京)
    • Related Report
      2018 Research-status Report
  • [Presentation] Acceleration of wound healing induced by hyaluronic acid (3) 発表区分2018

    • Author(s)
      Yayoi Kawano, Rihoko Kageyama, Takuya Iyoda, Fumio Fukai, Takehisa Hanawa
    • Organizer
      European Congress on Biotechnology 2018(Geneva)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 錠剤嚥下時の挙動観察を目的とした硫酸バリウム錠剤の調製と評価2018

    • Author(s)
      青木 野恵,河野 弥生,沖田 浩一,源田 亮二,八幡 徹太郎,花輪 剛久
    • Organizer
      第62回日本薬学会関東支部大会(東京)
    • Related Report
      2018 Research-status Report
  • [Presentation] ポリ塩化ビニルの温度応答性薬物担体への応用2018

    • Author(s)
      瀬谷 翼,河野 弥生, 花輪 剛久
    • Organizer
      第62回日本薬学会関東支部大会(東京)
    • Related Report
      2018 Research-status Report
  • [Presentation] 酢酸誘発性口内炎モデルに対するレバミピドの治療効果に関する検討 発表区分2018

    • Author(s)
      白石 拓也,河野 弥生,花輪 剛久,佐藤 光利
    • Organizer
      日本薬学会第138年会(金沢、石川県立音楽堂他)
    • Related Report
      2017 Research-status Report
  • [Presentation] 褥瘡治療を目的とした温度応答性ゲル製剤の開発2017

    • Author(s)
      村田 大貴,河野 弥生,岩野 友香,嶋田 修治,花輪 剛久
    • Organizer
      日本薬学会第138年会(金沢、石川県立音楽堂他)
    • Related Report
      2017 Research-status Report
  • [Presentation] 膵液瘻ラットモデルにおける新規ハイドロゲル製剤の治療効果に関する研究2017

    • Author(s)
      釼持 明, 田村 孝史, 清水 義夫, 大和田 洋平, 小澤 佑介, 儘田 大, 河野 弥生, 花輪 剛久, 大河内 信弘
    • Organizer
      総合研究院トランスレーショナルリサーチセンター第7回シンポジウム/研究交流会(東京)
    • Related Report
      2017 Research-status Report
  • [Presentation] Development and Characterization of the Patient-Friendly Formulations: Preparation and Characterization of a Suspension Containing Nanoparticulated Rebamipide for Stomatitis2017

    • Author(s)
      Yayoi Kawano, Naoko Ishii, Yuichiro Shimizu, Takehisa Hanawa
    • Organizer
      "6th FIP Pharmaceutical Sciences World Congress 2017 "(Stockholm, Sweden, 21-24 May 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 患者に優しい製剤の開発ーポリビニルアルコール系樹脂(Exceval)のハイドロゲル製剤への応用ー2017

    • Author(s)
      儘田 大, 河野 弥生, 大山 智子, 廣木 章博, 田口 光正, 花輪 剛久
    • Organizer
      日本薬学会第137年会(宮城県仙台市・仙台国際センター)
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] ハイドロゲルの評価方法2019

    • Inventor(s)
      花輪剛久
    • Industrial Property Rights Holder
      花輪剛久
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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