| Project/Area Number |
17K08519
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Fukuoka International University of Health and Welfare (2019-2020)
International University of Health and Welfare (2017-2018) |
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Principal Investigator |
Kosaka Katsuko 福岡国際医療福祉大学, 医療学部, 教授 (60202058)
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| Co-Investigator(Kenkyū-buntansha) |
小坂 俊夫 国際医療福祉大学, 福岡保健医療学部, 特任教授 (00126054)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 感覚 / 中枢神経系 / ニューロン / ドーパミン / GABA / 局所回路 / 免疫組織化学 / 嗅球 / secretagogin / 傍糸球体細胞 / 比較解剖学 / ドーパミン(DA)‐GABAニューロン / 鼻孔閉鎖 / 局所回路ニューロン / 解剖学 / 組織学 / 嗅覚系 |
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| Outline of Final Research Achievements |
The main olfactory bulbs (MOBs) are one of the most interesting parts of the brain; as an excellent model for understanding the neural mechanisms of sensory information processing and as one of the most prominent sites of the adult neurogenesis. Among the neurons in the MOBs TH expressing (DA-GABAergic) neurons might be most controversial. The structural features of DA-GABAergic neurons in the mouse MOBs were examined, using both wild type and transgenic TH-GFP mice. DA-GABAergic neurons were clustered in the glomerular layer (GL) but they also scattered in other layers. DA-GABAergic juxtaglomerular neurons, were classified into 5 groups based on their structural features and named as follows: 1) Large periglomerular cells. 2) Small periglomerular cells. 3) Transglomerular cells. 4) Incrusting cells. 5) Other various neurons not-yet classified. In the layers other than the GL various types of TH expressing neurons were scattered; some of them extended dendritic processes into the GL.
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| Academic Significance and Societal Importance of the Research Achievements |
嗅球は感覚情報処理及び成体ニューロン新生のモデルとして注目されている。TH発現ニューロンは糸球体間の抑制に働き機能的に重視されている。また、糸球体層新生ニューロンの主グループとしても注目されている。しかし、TH発現ニューロンが多様であることはほとんど考慮されていないのが現状である。我々のTH発現ニューロンの多様性を示した研究は今後の機能・ニューロン新生を考える上で、重要になってくると考えられる。
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