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Suppression of oxidative stress and diminution of cytoskeleton in macrophage under hypomagnetic field

Research Project

Project/Area Number 17K08563
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionTohoku University

Principal Investigator

Miyata Hidetake  東北大学, 理学研究科, 准教授 (90229865)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords微小磁場 / マクロファージ / ミトコンドリア / スーパーオキシドアニオン / 細胞内ATP / ネクローシス / 微弱磁場 / 地磁気 / 地球磁場
Outline of Final Research Achievements

Magnetic fields in space or on the moon (termed HMF) are considerably weaker than the earth geomagnetic field. Since HMF is not experienced on earth, the prolonged activities of men in space have raised concern about human health in space. Previous studies on cells have reported that mitochondrial membrane potential, ATP level and cell proliferation were altered under HMF condition. We have compared mitochondrial membrane potential, cell proliferation and ATP level in mouse macrophage cultured in HMF with those in macrophage cultured in geomagnetic field. The membrane potential significantly decreased and cell proliferation tended to decrease after 48-h culturing. The ATP level was not affected, which was different from a previous study and our anticipation, because the decline of the membrane potential would lead to the decrease in ATP production. Our result suggests that prolonged exposure of men to the HMF may affect their health through the alteration of mitochondrial function.

Academic Significance and Societal Importance of the Research Achievements

本研究の重要な成果として、HMF下で培養されたマクロファージにおいて、ミトコンドリアの膜電位が低下することが挙げられる。宇宙への人間の進出と共に、HMF環境下での長期にわたる活動が不可避的になっている。この影響は決して強いものではなかったが、24時間より48時間曝露の方が効果は強かった。われわれは通常地磁気(GMF)下で生活しているため、HMF下での活動が健康影響をもたらすかどうかは不明である。しかし、細胞における呼吸を司るミトコンドリアに影響する以上、HMFの影響はたとえそれが弱くても長期的には深刻なものになるかもしれない。本研究は、HMFの健康影響を研究・解明する手掛かりを与えるといえる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (2 results) Book (1 results)

  • [Int'l Joint Research] ナレスアン大学生物学科(タイ)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Evaluation of the Effects of Hypo-Magnetic Fields on Mouse Macrophage RAW264 Cells2020

    • Author(s)
      Srimai Nipitpon、Kiatarkom Wasawat、Miyata Hidetake
    • Journal Title

      International Journal of Chemistry

      Volume: 13 Issue: 1 Pages: 12-20

    • DOI

      10.5539/ijc.v13n1p12

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell physiological responses of RAW264 macrophage cells to a 50-Hz magnetic field2020

    • Author(s)
      Nishigaki Chihiro、Nakayama Maresuke、Miyata Hidetake
    • Journal Title

      International Journal of Radiation Biology

      Volume: 96 Issue: 12 Pages: 1628-1632

    • DOI

      10.1080/09553002.2020.1837983

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic sense of living organisms and electromagnetic hypersensitivity2019

    • Author(s)
      宮田英威
    • Journal Title

      Indoor Environment

      Volume: 22 Issue: 2 Pages: 209-215

    • DOI

      10.7879/siej.22.209

    • NAID

      130007687135

    • ISSN
      1882-0395, 2186-4322
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生物の磁場感受性と電磁過敏症2019

    • Author(s)
      宮田英威
    • Journal Title

      室内環境 印刷中

      Volume: 印刷中

    • NAID

      130007687135

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of a 50-Hz Magnetic Field on the Degradation of Plasmid in the Presence of Cu(II) Ions and Hydrogen Peroxide2017

    • Author(s)
      Kawashima Yuuichi、Fujii Honoka、Nakayama Maresuke、Hasegawa Masahiko、Shimanuki Satoru、Miyata Hidetake
    • Journal Title

      International Journal of Chemistry

      Volume: 9 Issue: 4 Pages: 40-40

    • DOI

      10.5539/ijc.v9n4p40

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 微弱磁場が細胞に与える影響の研究2018

    • Author(s)
      宮田英威、二ピポン スリマイ
    • Organizer
      第27回日本臨床環境医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 低周波磁場がマクロファージRAW264に及ぼす細胞生物学的影響の検討2017

    • Author(s)
      Marootpong Pooam、中山希祐、西垣千尋、宮田英威
    • Organizer
      日本臨床環境医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Book] Physical principles of biomembranes and cells2018

    • Author(s)
      Kazuo Ohki, Hidetake Miyata
    • Total Pages
      170
    • Publisher
      Springer Japan, KK
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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