| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
N6-methyladenosine (m6A) RNA modification is an RNA modification that affects some RNA functions. Hypothalamic feeding center plays important role in the control of feeding and metabolism. In this study we found that FTO in a group of hypothalamic feeding center neurons plays indispensable role in the body weight control. Mechanistically, FTO demethylates m6A and controls alternative splicing of genes related to some neuronal functions. In the neurons, FTO stimulates feeding and alters nutrient utilization.
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