Clarification of the mechanism of S1P-signaling-induced exosome maturation on tumor-promoting inflammation
| Project/Area Number |
17K08594
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | スフィンゴシン1-リン酸 / スフィンゴシン１-リン酸 / シグナル伝達 / バイオイメージング |
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| Outline of Final Research Achievements |
The goal of our project is discovery of a key molecular mechanism to develop new therapy against cancer. To figure out this purpose, in this project, we tried to make clear the detailed molecular mechanism of sphingosine 1-phosphate (S1P) signaling-induced exosome maturation on tumor-promoting inflammation. Then we discover that protein kinase c (aPKC) is constantly activating downstream of constant S1P signaling in cancer cells. Moreover we found that the S1P-aPKC signaling plays a critical role on tumor progression and tumor metastasis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果のポイントは、これまでよく分かっていなかったエクソソームが関わる癌の増悪・遠隔転移の分子メカニズムについて、S1P-aPKCシグナリングという全く新たなキープレーヤーを見出した点である。また本研究の成果により、癌の増悪や遠隔転移に対して、S1P-aPKCシグナリングを分子レベルで制御する新たな治療法開発への道筋が示された。今後は、本研究成果を応用した新たながん治療法の実現へ向けて、S1P-aPKCシグナリングのさらに詳細な分子メカニズムの解明とリード化合物の創出を目指した分子標的創薬の研究を平行して進める。
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Involvement of Gβγ subunits of Gi protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes2018
Author(s)
Kajimoto, T., Mohamed, N.N.I., Badawy, S.M.M., Matovelo, S.A., Hirase, M., Nakamura, S., Yoshida, D., Okada, T., Ijuin, T., Nakamura, S.
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Journal Title
Journal of Biological Chemistry
Volume: 293
Issue: 1
Pages: 245-253
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Phospholipase D is Dispensable for Epidermal Growth Factor-Induced Chemotaxis2017
Author(s)
Hirai, C., Badawy, S.M.M., Zhang, L., Okada, T., Kajimoto, T., Nakamura, S.
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Journal Title
Kobe Journal of Medical Sciences
Volume: 62
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 非典型プロテインキナーゼCのスフィンゴシン-１リン酸による新規活性化メカニズム2019
Author(s)
Kajimoto, T., Caliman, A.D., Tobias, I.S., Okada, T., Pilo, C.A., Van, A.A., McCammon J.A., Nakamura, S., Newton, A.C.
Organizer
第71回 日本細胞生物学会大会
Related Report
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