| Project/Area Number |
17K08647
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
古賀 允久 福岡大学, 薬学部, 准教授 (60570801)
山内 淳史 福岡大学, 薬学部, 教授 (90341453)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エストロゲン / COPD / LXA4 / リポキシンA4 / 更年期 |
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| Outline of Final Research Achievements |
This study focused on the association between estrogen variation with aging in chronic obstructive pulmonary disease (COPD), an inflammatory lung disease, and serum amyloid A (SAA) and lipoxan A4 (LXA4), which are notable markers of chronic inflammation.
Ovariectomy, a model of menopause, exacerbated the expansion of alveolar diameter in elastase (PPE)-induced COPD model mice. The involvement of SAA in this phenomenon On the other hand, LXA4 increased or decreased in the presence and absence of estrogen and time course, and the distribution of LXA4 receptors in the lung also changed with a delay. This study showed that there is a complex linkage between estrogen and LXA4 over a time course.
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| Academic Significance and Societal Importance of the Research Achievements |
COPDにおいて、女性更年期でのエストロゲン減少がCOPD増悪に関与しており、LXA4とその受容体を制御していることが明らかとなった。LXA4は、アラキドン酸から合成される脂質メディエータであり、喘息と関係の深いロイコトリエンとの関係が深い。本研究により女性のCOPDにおいてはLXA4をターゲットとする治療が有効である可能性が示された。
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