The clinical and molecular pathological study of enteropathy-associated T-cell lymphoma.
| Project/Area Number |
17K08702
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松本 主之 岩手医科大学, 医学部, 教授 (10278955)
菅井 有 岩手医科大学, 医学部, 教授 (20187628)
八尾 隆史 順天堂大学, 医学部, 教授 (20243933)
竹下 盛重 福岡大学, 医学部, 教授 (90171636)
江崎 幹宏 佐賀大学, 医学部, 教授 (50335957)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 腸管症関連T細胞リンパ腫 / 比較ゲノムハイブリダイゼーション / 上皮内リンパ球 / HLA（ヒト白血球型抗原） / セリアック病 / 腸症関連T細胞リンパ腫 / MEITL / CD56 / CD8 / c-Met / c-Myc / Bcl2 / CD103 / DLBCL / FISH / IGH遺伝子 / 消化管リンパ腫 / T細胞リンパ腫 / EATL / MYC / MET / 免疫組織化学 / SLCO2A1 / SETD2 |
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| Outline of Final Research Achievements |
We studied the clinicopathological features in 24 enteropathy-associated T-cell lymphoma (EATL) cases. Four cases (17%) had large-cell lymphoma (type I), while 20 (83%) had medium-sized lymphoma (type II). Lymphoma cells in 3 type I cases showed CD56-positive, while the remaining one (4%) showed both CD56/CD8-negative and CD30-positive. In type II cases, lymphoma cells in 16 (80%) and 11 (55%) cases showed positive for CD56 and CD8, respectively. Intramucosal lymphoma spreading and enteropathy-like lesions were detected in 15 (71%) and 16 (76%) of 21 cases, with increased intraepithelial lymphocytes (IELs) in 12 (57%). Comparative genomic hybridization of 15 type II cases indicated gains of 8q2 (47%), Xp (53%) and Xq (73%) without gain of 9q3. Regarding human leucocyte antigen (HLA), six cases examined did not express DQB1*02 allele. In conclusion, Japanese type II EATL cases exhibited different histology, cytogenetic and HLA findings from those of type I EATL.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦では比較的稀なⅡ型enteropathy-associated T-cell lymphoma（EATL; 現monomorphic epitheliotropic intestinal T-cell lymphoma; MEITL）の詳細な病理組織学的および分子生物学的特徴を解析した研究である。本症は、極めて予後不良で致死率の高い疾患であるが、本研究に続く更なる研究により分子病理学的特徴が解明されることにより、今後、有効な治療薬の開発が期待される。
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Report
(5 results)
Research Products
(45 results)
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[Journal Article] 今月の主題 小腸腫瘍アトラス 主題 小腸悪性腫瘍の臨床2020
Author(s)
川崎啓祐, 鳥巣剛弘, 蔵原晃一, 川床慎一郎, 永塚真, 藤原美奈子, 大城由美, 末永文彦, 梁井俊一, 漆 久保順, 井原勇太郎, 梅野淳嗣, 森山智彦, 中村昌太郎, 菅井有, 松本主之
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Journal Title
胃と腸
Volume: 55
Issue: 11
Pages: 1349-1359
DOI
ISSN
0536-2180, 1882-1219
Year and Date
2020-10-25
Related Report
Peer Reviewed
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[Journal Article] 増刊号 消化管腫瘍の内視鏡診断2020 主題 -小腸腫瘍性病変の内視鏡診断-リンパ増殖性疾患の診断2020
Author(s)
梁井 俊一, 中村 昌太郎, 川崎 啓祐, 赤坂 理三郎, 鳥谷 洋右, 大泉 智史, 久米井 智, 平井 みなみ, 山田 峻, 菅井 恭平, 石田 和之, 上杉 憲幸, 菅井 有, 松本 主之
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Journal Title
胃と腸
Volume: 55
Issue: 5
Pages: 637-645
DOI
ISSN
0536-2180, 1882-1219
Year and Date
2020-05-24
Related Report
Peer Reviewed
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[Journal Article] Long-term outcomes and prognostic factors with non-curative endoscopic submucosal dissection for gastric cancer in elderly patients aged ≧75 years.2019
Author(s)
Toya Y, Endo M, Nakamura S, Akasaka R, Yanai S, Kawasaki K, Koeda K, Eizuka M, Fujita Y, Uesugi N, Ishida K, Sugai T, Matsumoto T.
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Journal Title
Gastric Cancer.
Volume: 印刷中
Issue: 4
Pages: 877-878
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 全消化管を観察し得た胃・小腸monomorphic epitheliotropic intestinal T-cell lymphomaの一例2020
Author(s)
漆久保順, 梁井俊一, 川崎啓祐, 赤坂理三郎, 富田一光, 鳥谷洋右, 朝倉謙輔, 大泉智史, 郷内貴弘, 久米井智, 平井みなみ, 山田 峻, 菅井恭平, 中村昌太郎, 西谷真来, 菅原教史, 阿保亜紀子, 伊藤薫樹, 菅井 有, 松本主之.
Organizer
第16回日本消化管学会総会学術集会
Related Report
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[Presentation] High-dose clarithromycin mono therapy for Helicobacter pylori-negative or -eradicated gastrointestinal MALT lymphomas: A multi center trial in Japan.2020
Author(s)
Nakamura S, Matsumoto T, Tokunaga K, Ito M, Okada H, Esaki M, Ono S, Amagai K, Kobayashi H, Yoshino T, Kato M.
Organizer
The 13th International Gastrointestinal Consensus Symposium 第16回日本消化管学会総会学術集会
Related Report
Int'l Joint Research
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