| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Molecular pathological analysis of influenza-associated fatal cases showed that the viral genome can be detected in peripheral lung tissues infected with A/H1N1pdm09 subtype influenza virus compared with A/H3N2 subtype, and that the pulmonary pathological findings of diffuse alveolar damage may be different depending on the subtype. This suggests that the risk of severe disease may differ depending on the subtype.
In the pathogenesis of severe influenza, even though influenza virus antigens and genomes were detected in monocyte macrophages, it was unclear whether viral replication was occurring. 3D analysis using electron microscopy revealed differences in the localization of virus particles and the presence or absence of replication intermediate structures in monocyte macrophages and alveolar epithelial cells.
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