| Project/Area Number |
17K08981
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
Honda Takayuki 信州大学, 学術研究院医学系, 教授 (80238815)
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| Co-Investigator(Kenkyū-buntansha) |
松本 剛 信州大学, 医学部, 助教(特定雇用) (70600518)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 白血球 / 左方移動 / 桿状核球 / 好中球 / 細菌感染症 / 感染症 / 診断検査 / 重症度判定 |
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| Outline of Final Research Achievements |
It is necessary to correctly and rapidly diagnose a patient with a bacterial infection. However, CRP and Procalcitonin, which are clinically used as laboratory tests for bacterial infections, often positive even in patients with non-infectious diseases. Their accuracy is low. Left shift of the neutrophil (increase of the band cell), in the other hand, real-timely changes according to the state of a bacterial infection, and it is useful to diagnose and follow a patient. Therefore, we studied 300 patients, who were admitted to the critical care center. The percentage of band cells in the patient with a bacterial infection was higher than that in non-infectious diseases, and the ROC analysis showed the percentage of the band cell was useful to diagnose a bacterial infection.
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| Academic Significance and Societal Importance of the Research Achievements |
細菌感染症、特に致死率の高い敗血症では、早期の診断と治療開始が重要である。近年様々なバイオマーカーが利用されているが、使い分けや結果の解釈に迷うことがあり、さらには専用の測定機器が必要で、どの医療機関でも利用できるわけではない。それに対して桿状核好中球は、体内に侵入した細菌に対する反応そのものを見ており、さらには特殊な測定機器がなくても検査が実施できるため、感染症診断と病態把握に有用であると考えられる。
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