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Multimarker approach to risk stratification for acute kidney injury and cardiorenal events in patients admitted to medical cardiac intensive care units

Research Project

Project/Area Number 17K08995
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionFujita Health University

Principal Investigator

Ishii Junichi  藤田医科大学, 医学部, 教授 (70222940)

Co-Investigator(Kenkyū-buntansha) 成瀬 寛之  藤田医科大学, 医学部, 准教授 (50319266)
松井 茂  藤田医科大学, 保健学研究科, 准教授 (20308901)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords急性腎障害 / L型脂肪酸結合蛋白 / N末端プロB型ナトリウム利尿ペプチド / 内科系心臓集中治療室 / 長期予後 / 好中球ゼラチナーゼ関連リポカリン / 冠疾患集中治療室 / 尿中L型脂肪酸結合蛋白 / 内科
Outline of Final Research Achievements

The relevance of renal tubular injury marker "urinary L-type fatty-acid binding protein" in medical cardiac intensive care units is not clear. To prospectively investigate the utility of multimarker approach combining use of different biomarkers, we measured biomarkers including urinary L-type fatty-acid binding protein and plasma N-terminal pro-B-type natriuretic peptide in 1400 patients admitted to medical cardiac intensive care units. Of these, both L-type fatty acid-binding protein and N-terminal pro-B-type natriuretic peptide on admission were significant independent predictors of acute kidney injury and cardiorenal events, and when used in combination, improved the early prediction of acute kidney injury and cardiorenal events.

Academic Significance and Societal Importance of the Research Achievements

尿中L型脂肪酸結合蛋白と血漿N末端プロB型ナトリウム利尿ペプチドは一般的な検査室においても簡便・迅速に測定できる。したがって、これらを組み合わせたマルチマーカーアプローチの内科系心臓集中治療室への導入は、急性腎障害および心腎イベントの発症リスクを入室後早期に、しかも高い精度で層別できると考えられる。そのため、内科系心臓集中治療室入室患者に対してリスクに基づく適時・適切な治療介入を可能とし、予後の改善に繋がると予想される。さらに、医療経済への貢献も期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Urinary Liver-Type Fatty-Acid-Binding Protein Predicts Long-Term Adverse Outcomes in Medical Cardiac Intensive Care Units2020

    • Author(s)
      Naruse H, Ishii J, Takahashi H, et al.
    • Journal Title

      J Clin Med

      Volume: 9(2) Issue: 2 Pages: 482-482

    • DOI

      10.3390/jcm9020482

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Authors’ response to letter “Prediction of acute kidney injury in intensive care unit patients”2019

    • Author(s)
      Naruse H, Ishii J, Takahashi H
    • Journal Title

      Critical Care

      Volume: 23 Issue: 1 Pages: 58-58

    • DOI

      10.1186/s13054-019-2340-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units.2018

    • Author(s)
      Naruse H, Ishii J, Takahashi H, et al.
    • Journal Title

      Critical Care

      Volume: 22 Issue: 1 Pages: 197-197

    • DOI

      10.1186/s13054-018-2120-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Urinary Liver-Type Fatty-Acid Binding Protein Relative to Urinary Neutrophil Gelatinase-Associated Lipocalin for Predicting Acute Kidney Injury in Patients Treated at Medical Cardiac Intensive Care Units2019

    • Author(s)
      Nishimura T, Ishii J, Kawai H, et al.
    • Organizer
      Scientific Sessions 2019 American Heart Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combined Assessment of Urinary Liver-Type Fatty Acid-Binding Protein and Plasma B-Type Natriuretic Peptide Improves Prediction of Long-Term Outcomes in Patients Treated at Medical Cardiac Intensive Care Units2019

    • Author(s)
      Naruse H, Ishii J, Nishimura T, et al.
    • Organizer
      Scientific Sessions 2019 American Heart Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Urinary Liver-Type Fatty Acid-Binding Protein and N-Terminal Pro-B-Type Natriuretic Peptide Predict Acute Kidney Injury in Patients with Acute Coronary Syndrome2019

    • Author(s)
      Naruse H, Ishii J, Nishimura T, et al.
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Combined Assessment of Urinary Liver-Type Fatty-Acid Binding Protein and Serum N-Terminal Pro-B-Type Natriuretic Peptide Levels on Admission Improves Prediction of Acute Kidney Injury in Patients with Acute Coronary Syndrome2018

    • Author(s)
      Naruse H, Ishii J, Nishimura T, et al.
    • Organizer
      Scientific Sessions 2018 American Heart Association
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Urinary Liver-Type Fatty-Acid Binding Protein and Serum N-Terminal Pro-B-Type Natriuretic Peptide Predict Acute Kidney Injury in Patients2018

    • Author(s)
      Naruse H, Ishii J, Okuyama R, et al.
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Combined Assessment of Urinary Liver-Type Fatty-Acid Binding Protein and Serum N-Terminal Pro-B-Type Natriuretic Peptide Levels Improves Prediction of Acute Kidney Injury in Patients Hospitalized to Coronary Care Units2017

    • Author(s)
      Naruse H, Ishii J, Nishimura T, et al.
    • Organizer
      Scientific Sessions 2017 American Heart Association
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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