| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We have elucidated the significance of stemness-related signaling molecules such as NOTCH, Hedgehog, BMI1, HIF, MERTK in the growth of acute leukemia cells. We have also showed that the inhibitors of the above signals suppressed the growth of leukemia cells and how the inhibitors affected the signaling molecules. Knockdown of the genes to produce the above signaling molecules showed the same effects as the inhibitors, which indicates that the effects of the inhibitors were not due to off-target effects.
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