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Role of antipruritus and analgesia through TRPV1 channel

Research Project

Project/Area Number 17K09033
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionShimane University

Principal Investigator

Imamachi Noritaka  島根大学, 学術研究院医学・看護学系, 准教授 (40325048)

Co-Investigator(Kenkyū-buntansha) 齊藤 洋司  島根大学, 学術研究院医学・看護学系, 教授 (50162243)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsTRPV1 / Itch / Opioid / 術後鎮痛 / モルヒネ / 鎮痛 / 体温 / オピオイド / 痒み / 鎮痒
Outline of Final Research Achievements

TRPV1 not only is activated by multiple stimuli but also is involved with histamine-induced itch.The effects of TRPV1 on morphine-induced itch are unknown.We examined the effects of intrathecal administration of TRPV1 antagonist on morphine-induced itch, body temperature, and antinociception for mice.SB366791 dose-dependently reduced the scratching behavior induced by the administration of morphine. SB366791 and the morphine + SB366791 groups did not manifest an increase in body temperature. Antinociceptive effects were observed to occur dose-dependently for morphine but not for SB366791. Compared with morphine alone, the administration of morphine + SB366791 did not reduce significant antinociceptive effects.We propose that an intrathecal TRPV1 antagonist, SB366791, reduced morphine-induced itch without causing hyperthermia and did not suppress morphine-induced antinociception for mice.

Academic Significance and Societal Importance of the Research Achievements

TRPV1拮抗薬は新しい鎮痛薬として期待されてきたが、TRPV1拮抗薬を全身投与すると高体温となるため、現在のところ臨床応用されていない。今回われわれは、極少量のTRPV1拮抗薬を髄腔内に投与する手法で未だに治療法が確立されていないモルヒネによる痒みに有効であるかを調べた。結果として極少量のTRPV1拮抗薬の髄腔内投与であれば高体温を生ずることなくモルヒネの鎮痛効果に影響を与えずにモルヒネによる痒みを抑える可能性を示した。この方法は今後のモルヒネによる痒みを治療する方法の一つとして学術的意義
があると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice</p>2019

    • Author(s)
      Sakakibara Satoshi、Imamachi Noritaka、Sakakihara Manabu、Katsube Yukiko、Hattori Mai、Saito Yoji
    • Journal Title

      Journal of Pain Research

      Volume: Volume 12 Pages: 2629-2636

    • DOI

      10.2147/jpr.s217439

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Incidence of Chronic Postsurgical Pain After Inguinal Hernia Surgery: Association with the Acute Postsurgical Pain: A Preliminary Study Based on Questionnaires.2018

    • Author(s)
      Imamachi N, Doi K, Watanab Y , Saito Y.
    • Journal Title

      Shimane Journal of Medicine Science

      Volume: 34 Pages: 93-97

    • NAID

      120006425805

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 痒みの神経機構2018

    • Author(s)
      今町憲貴
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 38 Pages: 322-329

    • NAID

      130007410213

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 帝王切開時の脊髄くも膜下オピオドによる痒みに対する予防的ペンタゾシン投与の効果2018

    • Author(s)
      平林政人、土井克史、今町憲貴、岸本朋宗,齊藤洋司
    • Journal Title

      麻酔

      Volume: 67

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 帝王切開術中の低酸素頻度の発生頻度と危険因子の検討2018

    • Author(s)
      稲場 聡、今町憲貴、平林政人、榊原賢司、土井克史、齊藤洋司
    • Organizer
      日本麻酔科学会第65回学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] エムラクリームが予定帝王切開術患者の局所麻酔・硬膜外麻酔時痛に及ぼす影響:前向き無作為化二重盲検比較試験2018

    • Author(s)
      上田陽子、土井克史、岸本朋宗、今町憲貴、齊藤洋司
    • Organizer
      日本麻酔科学会第65回学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 帝王切開時の脊髄くも膜下オピオイドによる痒みに対する予防的ペンタゾシン投与の効果2018

    • Author(s)
      平林政人、土井克史、今町憲貴、岸本朋宗、齊藤洋司
    • Organizer
      日本麻酔科学会第65回学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] The Incidence of Hypoxia During Cesarean Delivery Under Spinal Anesthesia2018

    • Author(s)
      Hirabayashi M, Imamachi N,,Inaba I,Sakakibara S,Doi K, Saito Y
    • Organizer
      American Society of Anesthesiologists 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 帝王切開術中に脊髄くも膜下フェンタニルにより生じた痒みの治療に難渋した2症例2017

    • Author(s)
      宇賀田圭、今町憲貴、榊原賢司、榊原学、土井克史、齊藤洋司
    • Organizer
      日本区域麻酔学会第4回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 帝王切開術中の低酸素血症の発生頻度と脊髄くも膜下オピオイドとの関連性2017

    • Author(s)
      稲場 聡、今町憲貴、平林政人、榊原賢司、齊藤洋司
    • Organizer
      島根麻酔医学会第32回大会
    • Related Report
      2017 Research-status Report
  • [Book] 麻酔科医のためのリスクを有する患者の周術期管理 1章リスクを有する患者での麻酔の考え方.1-5オピオイドを使いこなすために2018

    • Author(s)
      今町憲貴, 齊藤洋司
    • Total Pages
      10
    • Publisher
      中山書店
    • ISBN
      9784521743271
    • Related Report
      2018 Research-status Report
  • [Book] 麻酔科 研修ノート改訂第3版  18章 麻酔合併への対処 3 神経障害:全身麻酔、区域麻酔、体位2018

    • Author(s)
      今町憲貴, 齊藤洋司
    • Total Pages
      5
    • Publisher
      診断と治療社
    • ISBN
      9784787824011
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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