| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Chronic pain is a pathological condition in which pain lasts for a long time, and touch stimulation causes pain or pain is enhanced in this condition. Recently, it has shown that the reorganization of neural circuits in the primary somatosensory cortex (S1) is associated with the onset and maintenance of chronic pain after peripheral nerve injury. Thus, it is possible that chronic pain might be caused by crosstalk between touch-sensitive neural circuit and pain-sensitive neuronal circuits in the S1. The purpose of this study was to visualize the touch- and pain-sensitive neuronal circuits and to clarify how these neuronal activities change after peripheral nerve injury. As a result, it was revealed that a part of the touch-sensitive neurons responded to the pain stimulus. Moreover, it was clarified the new role of S1 in the mirror image pane, which is one of chronic pain.
|
