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formation of the abnormal neuronal circuit between the touch-sensitive and pain-sensitive neuronal circuit in the primary somatosensory cortex during chronic pain

Research Project

Project/Area Number 17K09051
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

Eto Kei  生理学研究所, 基盤神経科学研究領域, 助教 (30545257)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords痛み / 2光子顕微鏡 / 一次体性感覚野 / 神経細胞 / 慢性疼痛 / 触覚
Outline of Final Research Achievements

Chronic pain is a pathological condition in which pain lasts for a long time, and touch stimulation causes pain or pain is enhanced in this condition. Recently, it has shown that the reorganization of neural circuits in the primary somatosensory cortex (S1) is associated with the onset and maintenance of chronic pain after peripheral nerve injury. Thus, it is possible that chronic pain might be caused by crosstalk between touch-sensitive neural circuit and pain-sensitive neuronal circuits in the S1. The purpose of this study was to visualize the touch- and pain-sensitive neuronal circuits and to clarify how these neuronal activities change after peripheral nerve injury. As a result, it was revealed that a part of the touch-sensitive neurons responded to the pain stimulus. Moreover, it was clarified the new role of S1 in the mirror image pane, which is one of chronic pain.

Academic Significance and Societal Importance of the Research Achievements

本課題では未だに有効な治療法に乏しい慢性疼痛の新たな機序を明らかにできたことから、学術的に意義がある。また、大脳皮質に着目した新たな治療法の確立のきっかけになる可能性を有しており、社会的意義も有する。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 2 results) Book (1 results)

  • [Int'l Joint Research] University of New South Wales(オーストラリア)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] The University of New South(Australia)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Kyung Hee University(Sun Kwang Kim)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Overexpression of neuronal K+-Cl- co-transporter enhances dendritic spine plasticity and motor learning.2019

    • Author(s)
      Nakamura K, Moorhouse AJ, Cheung DL, Eto K, Takeda I, Rozenbroek PW, Nabekura J
    • Journal Title

      Journal of Physiological Sciences

      Volume: 69 Issue: 3 Pages: 453-463

    • DOI

      10.1007/s12576-018-00654-5

    • NAID

      40021874177

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The roles of cortical astrocytes in chronic pain and other brain pathologies2018

    • Author(s)
      Eto Kei、Kim Sun Kwang、Takeda Ikuko、Nabekura Junichi
    • Journal Title

      Neuroscience Research

      Volume: 126 Pages: 3-8

    • DOI

      10.1016/j.neures.2017.08.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cortical astrocytes prime the induction of spine plasticity and mirror image pain.2018

    • Author(s)
      Ishikawa T, Eto K, Kim SK, Wake H, Takeda I, Horiuchi H, Moorhouse AJ, Ishibashi H, Nabekura J.
    • Journal Title

      Pain

      Volume: 印刷中 Issue: 8 Pages: 1592-1606

    • DOI

      10.1097/j.pain.0000000000001248

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Activity-dependent functions of non-electrical glial cells2018

    • Author(s)
      Kato Daisuke、Eto Kei、Nabekura Junichi、Wake Hiroaki
    • Journal Title

      The Journal of Biochemistry

      Volume: 印刷中 Issue: 6 Pages: 457-464

    • DOI

      10.1093/jb/mvy023

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 慢性疼痛モデルマウスにおける大脳皮質体性感覚野神経回路再編とグリア機能2017

    • Author(s)
      江藤圭、金善光、鍋倉淳一
    • Journal Title

      臨床雑誌整形外科

      Volume: 68 Pages: 1284-1284

    • Related Report
      2017 Research-status Report
  • [Presentation] 大脳皮質体性感覚野神経回路可塑的変容の慢性疼痛における役割2017

    • Author(s)
      江藤 圭
    • Organizer
      第10回日本運動器疼痛学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 一次体性感覚野による慢性疼痛発生機構.2017

    • Author(s)
      3.江藤 圭
    • Organizer
      第59回基礎歯科医学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] The role of cortical inhibitory neuronal function in chronic pain.2017

    • Author(s)
      Kei Eto, Hitoshi Ishibashi, Junichi Nabekura.
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society.
    • Related Report
      2017 Research-status Report
  • [Book] 実験医学増刊2018

    • Author(s)
      江藤 圭,竹田育子,鍋倉淳一
    • Total Pages
      8
    • Publisher
      羊土社
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-12-28  

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