| Project/Area Number |
17K09067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アルツハイマー型認知症 / 遺伝子 / MR画像 / コンピュータ支援診断 / Radiogenomics / 認知症 |
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| Outline of Final Research Achievements |
We constructed next-generation computer-aided diagnosis by the integration analysis of genetic and image tests. We found that the process of disease formation is different in mild cognitive impairment and Alzheimer’s diseases (AD) according to the APOE genotype. Therefore, the early detection of AD would be possible by the image interpretation considering patient’s genotype. We also developed a method for distinguishing normal patients from ADs on the eigenspace by creating an eigenspace from normal MR images of 60, 70 and 80 ages. The proposed method made it possible to quantitatively evaluate the degree of cerebral atrophy considering the effects of normal aging. Since this method represents cerebral atrophy in a low-dimensional eigenspace, it has the advantage of avoiding the multiple test problem without setting a region of interest at a specific part of the brain.
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| Academic Significance and Societal Importance of the Research Achievements |
遺伝子検査と画像検査の統合解析による次世代型のコンピュータ支援診断の新しい概念の研究を構築した点で学術的意義は大きい．この新しい概念は，認知症以外の他疾患にも適用可能であり，関連分野の進展に貢献できる．遺伝学的検査によって個人の遺伝型が特定できれば，認知症になりやすい患者群を特定することができる．そのような患者群は，発症を早期に発見するために，定期的な検査が行われるであろう．定期検査の際に，その患者の遺伝型に関係する画像特徴の変化（脳萎縮）が特定できれば，その変化に注目して読影を行うことができるため，現在よりも早期に病気を検出できる可能性が高く，社会的意義も大きい．
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