Examination of cross-sectional and longitudinal relationships between physical examination data including physical fitness results and bone density

• Project/Area Number: 17K09104
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Niigata University
• Principal Investigator: Kato Kiminori 新潟大学, 医歯学総合研究科, 特任教授 (00303165)
• Co-Investigator(Kenkyū-buntansha): 曽根 博仁 新潟大学, 医歯学系, 教授 (30312846) ; 児玉 暁 新潟大学, 医歯学総合研究科, 特任准教授 (50638781)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨粗鬆症 / 耐糖能低下 / 体力測定 / 握力 / 垂直飛び / 立位前屈 / 全身反応性 / 健康診断

Outline of Final Research Achievements

Bone density data of about 90,000 people in total was analyzed. In a cross-sectional analysis with physical fitness measurements, the only factors independently associated with bone density were sex, age, weight, grip strength, standing forward bending, and whole-body reaction time. In a longitudinal analysis, the only factors independently associated with changes in bone density were gender, grip strength, and vertical jump. In addition, we are conducting a “Questionnaire survey on bone fracture events among osteoporosis screening examinees” for 17,000 people with osteoporosis screening, and we are aiming to publish the results.

Academic Significance and Societal Importance of the Research Achievements

骨粗鬆症は、特に高齢女性にとっては喫緊の課題である。骨粗鬆症によって易骨折性となっている女性が、日常的に起こりうる転倒等で骨折に至ってしまうと老後のQOLは著しく低下する。この誰にでも起こりうる骨粗鬆症を防止することは、極めて大きな医療政策の柱ともなりうる課題である。今回、得られた結果では、骨密度変化と関連している因子は握力と垂直飛びであり、これらは筋力の指標である。特に、握力はサルコペニアの定義にもなっている重要な指標であり、これらを、生活指導、運動指導の成果の指標として使うことが出来ないかと期待され、その様な意味においても本研究は将来への介入研究の基礎ともなる研究である。

Research Products

• [Journal Article] Physical Fitness and Dyslipidemia Among Japanese: A Cohort Study From the Niigata Wellness Study (2021)
  • Author(s): Haruki Momma, Kiminori Kato, Susumu S. Sawada, Yuko Gando, Ryoko Kawakami, Motohiko Miyachi, Ryoichi Nagatomi, Minoru Tashiro, Yasuhiro Matsubayashi, Satoru Kodama, Midori Iwanaga, Kazuya Fujihara, Hirohito Sone
  • Journal Title: Journal of Epidemiology Volume: 31 Issue: 4 Pages: 287-296
  • DOI: 10.2188/jea.JE20200034
  • NAID: 130008021561
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-04-05
  • Peer Reviewed / Open Access
• [Journal Article] Meta-regression Analysis of Sex- and Birth Year-Specific Prevalence of HBsAg and Anti-HCV Among Un-diagnosed Japanese: Data From the First-time Blood Donors, Periodical Health Checkup, and the Comprehensive Health Checkup With Lifestyle Education (Ningen Dock) (2020)
  • Author(s): Akita Tomoyuki、Tanaka Junko、Satake Masahiro、Lin Yingsong、Wada Takashi、Kato Kiminori、Inoue Manami
  • Journal Title: Journal of Epidemiology Volume: 30 Issue: 9 Pages: 420-425
  • DOI: 10.2188/jea.JE20190055
  • NAID: 130007896964
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-09-05
  • Peer Reviewed / Open Access
• [Journal Article] Combination of diabetes mellitus and lack of habitual physical activity is a risk factor for functional disability in Japanese (2020)
  • Author(s): Fujihara Kazuya、Matsubayashi Yasuhiro、Harada Yamada Mayuko、Kitazawa Masaru、Yamamoto Masahiko、Kaneko Masanori、Kodama Satoru、Yahiro Takuya、Tsutsui Ayumu、Kato Kiminori、Sone Hirohito
  • Journal Title: BMJ Open Diabetes Research & Care Volume: 8 Issue: 1 Pages: e000901-e000901
  • DOI: 10.1136/bmjdrc-2019-000901
  • Peer Reviewed / Open Access
• [Journal Article] Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study (2019)
  • Author(s): Momma H, Sawada SS, Kato K, Gando Y, Kawakami R, Miyachi M, Huang C, Nagatomi R, Tashiro M, Ishizawa M, Kodama S, Iwanaga M, Fujihara K, Sone H
  • Journal Title: Journal of Epidemiology Volume: 29 Issue: 4 Pages: 139-146
  • DOI: 10.2188/jea.JE20170280
  • NAID: 130007624295
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2019-04-05
  • Peer Reviewed / Open Access
• [Journal Article] β 2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese. (2019)
  • Author(s): Mayuka Nakajima、Michihiro Hosojima、Koichi Tabeta、Sayuri Miyauchi、Miki Yamada-Hara、Naoki Takahashi、Haruna Miyazawa、Yumi Matsuda-Matsukawa、Keisuke Sato、Noriko Sugita、Yasutaka Komatsu、Tomomi Ishikawa、Kazuhiro Akiishi、Kazuhisa Yamazaki、Kiminori Kato、Akihiko Saito、Hiromasa Yoshie
  • Journal Title: International Journal of Dentistry Volume: 2019 Pages: 1-10
  • DOI: 10.1155/2019/1394678
  • Peer Reviewed / Open Access
• [Journal Article] Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey (2018)
  • Author(s): Tabeta K.、Hosojima M.、Nakajima M.、Miyauchi S.、Miyazawa H.、Takahashi N.、Matsuda Y.、Sugita N.、Komatsu Y.、Sato K.、Ishikawa T.、Akiishi K.、Yamazaki K.、Kato K.、Saito A.、Yoshie H.
  • Journal Title: Journal of Periodontal Research Volume: 印刷中 Issue: 3 Pages: 446-456
  • DOI: 10.1111/jre.12533
  • Peer Reviewed / Open Access
• [Journal Article] Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels. (2018)
  • Author(s): Sugawa S, Masuda I, Kato K and Yoshimura M.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 5120-5120
  • DOI: 10.1038/s41598-018-23441-z
  • Peer Reviewed / Open Access
• [Journal Article] Low-Dose Erythropoietin in Patients With ST-Segment Elevation Myocardial Infarction (EPO-AMI-II) ― A Randomized Controlled Clinical Trial ― (2018)
  • Author(s): Minamino, Tetsuo; Higo, Shuichiro; Araki, Ryo; Hikoso, Shungo; Nakatani, Daisaku; Suzuki, Hiroshi; Yamada, Takahisa; Okutsu, Masaaki; Yamamoto, Kouji; Fujio, Yasushi; Ishida, Yoshio; Ozawa, Takuya; Kato, Kiminori; Toba, Ken; Aizawa, Yoshifusa; Komuro, Issei
  • Journal Title: Circulation Journal Volume: 82 Issue: 4 Pages: 1083-1091
  • DOI: 10.1253/circj.CJ-17-0889
  • NAID: 130006528526
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Effect of family-oriented diabetes programs on glycemic control: A meta-analysis. (2018)
  • Author(s): Kodama S, Morikawa S, Horikawa C, Ishii D, Fujihara K, Yamamoto M, Osawa T, Kitazawa M, Yamada T, Kato K, Tanaka S and Sone H.
  • Journal Title: Fam Pract. Volume: 12 Issue: 4 Pages: 111-111
  • DOI: 10.1093/fampra/cmy112
  • Peer Reviewed / Open Access
• [Journal Article] Unstable body weight and incident type 2 diabetes mellitus - A meta-analysis (in press) (2017)
  • Author(s): Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K, Hanyu O, Sone H
  • Journal Title: Journal of diabetes investigation Volume: - Issue: 4 Pages: 501-509
  • DOI: 10.1111/jdi.12623
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of body mass index and metabolic phenotypes on coronary artery disease according to glucose tolerance status. (2017)
  • Author(s): Fujihara K, Matsubayashi Y, Yamamoto M, Osawa T, Ishizawa M, Kaneko M, Matsunaga S, Kato K, Seida H, Yamanaka N, Kodama S, Sone H
  • Journal Title: Diabetes Metab. Volume: 43(6) Issue: 6 Pages: 543-546
  • DOI: 10.1016/j.diabet.2017.08.002
  • Peer Reviewed
• [Journal Article] Carbohydrate intake during early pregnancy is inversely associated with abnormal glucose challenge test results in Japanese pregnant women. (2017)
  • Author(s): Tajima R, Yachi Y, Tanaka Y, Kawasaki YA, Nishibata I, Hirose AS, Horikawa C, Kodama S, Iida K, Sone H.
  • Journal Title: Diabetes Metab Res Rev. Volume: 33(6)
  • Peer Reviewed
• [Journal Article] Lower risk of progression from prediabetes to diabetes with health checkup with lifestyle education: Japan Ningen Dock study. (2017)
  • Author(s): Okada R, Tsushita K, Wakai K, Ishizaka Y, Kato K, Wada T and Watanabe K.
  • Journal Title: Nutr Metab Cardiovasc Dis. 2017;27: Volume: 27 Issue: 8 Pages: 679-687
  • DOI: 10.1016/j.numecd.2017.06.004
  • Peer Reviewed
• [Presentation] 骨密度に影響する身体測定値：人間ドックのデータ解析から (2017)
  • Author(s): 石澤 正博, 藤原 和哉, 田代 稔, 加藤 公則, 松永 佐澄志, 山田 貴穂, 羽入 修, 曽根 博仁
  • Organizer: 第90回日本内分泌学会学術総会
• [Presentation] 骨粗鬆症検診と体力測定の関係についての横断的解析 -Niigata Wellness Study- (2017)
  • Author(s): 加藤公則、石澤正博、児玉 暁、藤原和哉、小林隆司、田代 稔、佐藤幸示、北川 寛、笹川 力、曽根博仁
  • Organizer: 第58回 日本人間ドック学会学術大会
• [Presentation] 骨粗鬆症検診と体力測定の関係についての縦断的解析 -Niigata Wellness Study- (2017)
  • Author(s): 加藤公則、石澤正博、児玉 暁、藤原和哉、小林隆司、田代 稔、佐藤幸示、北川 寛、笹川 力、曽根博仁
  • Organizer: 第58回 日本人間ドック学会学術大会
• [Presentation] 骨粗鬆症検診と体力測定の関係-人間ドック受診者では握力と垂直飛びが骨密度と関連する- (2017)
  • Author(s): 加藤公則、上村伯人
  • Organizer: 第28回日本臨床スポーツ医学会学術集会