The risk assessment of the development of diabetes mellitus using genetic variants and fatty acid
Project/Area Number |
17K09113
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
二宮 利治 九州大学, 医学研究院, 教授 (30571765)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 疫学 / 遺伝的リスクスコア / 2型糖尿病発症 / 脂肪酸 / 糖尿病 / 疫学研究 / 危険因子 / 遺伝子 / 脂質 / ゲノム / 社会医学 |
Outline of Final Research Achievements |
The aim of the present study was to investigate the associations of genetic risk score (GRS) based on the literature-based effect size for type 2 diabetes (T2D) of 84 susceptibility loci for Japanese on the incidence of T2D among 1,465 subjects aged 40-79 years without diabetes who underwent health examination in 2002. Cox's proportional hazards model was used to estimate the association of GRS with T2DM during the 10 years of follow-up period. The risk of developing T2D increased significantly with elevating quintiles of GRS in the multivariable adjusted model. When incorporating GRS into the multivariable model comprising environmental risk factors, the predictive ability of T2D was significantly improved. These findings suggest the usefulness of GRS for identifying a high-risk population together with environmental risk factors in the Japanese population. Then, we analyzed the associations of fatty acid on T2D among 2336 subjects in 2002, though no unified view was obtained.
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Academic Significance and Societal Importance of the Research Achievements |
本研究の結果から、これまでにゲノムワイド研究において報告された84個の糖尿病感受性遺伝子を用いて作成した遺伝的リスクスコアは、既知の危険因子とは独立した糖尿病発症の有意な危険因子であることが示された。また、既知の危険因子に遺伝的リスクスコアを加えることで、糖尿病発症の予測能が有意に改善した。以上のことから、既知の危険因子に加えて、遺伝的リスクスコアを用いることで、糖尿病発症の高リスク群を早期に精度高く同定し、効率的な糖尿病予防戦略を行うことができると考えられる。
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Association of daily sleep duration with the risk of dementia and mortality in a Japanese community2018
Author(s)
Tomoyuki Ohara, Takanori Honda, Jun Hata, Daigo Yoshida, Naoko Mukai, Yoichiro Hirakawa, Mao Shibata, Hiro Kishimoto, Takanari Kitazono, Shigenobu Kanba, Toshiharu Ninomiya
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Journal Title
J Am Geriatr Soc
Volume: in press
Pages: 1911-1918
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study.2018
Author(s)
Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.
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Journal Title
J Am Heart Assoc
Volume: 7
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study2017
Author(s)
Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T
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Journal Title
J Atheroscler Thromb
Volume: 24
Issue: 7
Pages: 706-715
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Open Access
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[Journal Article] Alternative measures of hyperglycemia and risk of alzheimer's disease in the community: the Hisayama Study.2017
Author(s)
Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T
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Journal Title
The Journal of Clinical Endocrinology & Metabolism
Volume: 102
Pages: 3002-3010
DOI
Related Report
Peer Reviewed
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[Journal Article] Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population ― The Hisayama Study ―2017
Author(s)
Umehara K, Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Kishimoto H, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T
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Journal Title
Circ J
Volume: 81
Issue: 9
Pages: 1315-1321
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community: The Hisayama Study2017
Author(s)
Nagata M, Hata J, Hirakawa Y, Mukai N, Yoshida D, Ohara T, Kishimoto H, Kawano H, Kitazono T, Kiyohara Y, Ninomiya T
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Journal Title
Journal of Epidemiology
Volume: 27
Issue: 12
Pages: 578-583
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed / Open Access
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[Presentation] Serum mac-2 binding protein glycosylation isomer level and the risk of type 2 diabetes in a Japanese community: the Hisayama Study2019
Author(s)
Higashioka M, Hirakawa Y, Yoshinari M, Honda T, Sakata1 S, Shibata M, Yoshida D, Hata J, Kitazono T, Osawa H, Ninomiya T
Organizer
79th American Diabetes Association Scientific Session
Related Report
Int'l Joint Research
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[Presentation] Glucose tolerance status and beta and alpha cell mass in community-based autopsy samples of Japanese: the Hisayama Study.2019
Author(s)
Inaishi J, Saisho Y, Mukai N, Hirakawa Y, Yoshida D, Hata J, Watanabe Y, Oda Y, Itoh H, Ninomiya T
Organizer
55th Annual Meeting of the European Association for the Study of Diabetes, Barcelona, Spain, 2019.9
Related Report
Int'l Joint Research
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[Presentation] Albuminuria is a biomarker for severity of white matter hyperintensities on brain MRI in a general elderly population of Japanese: the Hisayama Study.<poster>2019
Author(s)
Yamasaki K, Hata J, Hirabayashi N, Furuta Y, Ohara T, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T
Organizer
ASN Kidney Week 2019, Washinton, DC, USA, 2019.11
Related Report
Int'l Joint Research
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[Presentation] Urinary N-terminal pro-brain natriuretic peptide is a useful biomarker for cardiovascular events in a general Japanese population: the Hisayama Study.<poster>2019
Author(s)
Yamasaki K, Hata J, Hirakawa Y, Sakata S, Nakano T, Kitazono T, Ninomiya T
Organizer
ASN Kidney Week 2019, Washinton, DC, USA, 2019.11
Related Report
Int'l Joint Research
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[Presentation] Serum NT-proBNP Level is a Predictor for Developing Atrial Fibrillation in a General Japanese Population: the Hisayama Study.2019
Author(s)
Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T
Organizer
American Heart Association Scientific Sessions 2019, Philadelphia, PA, USA, 2019.11
Related Report
Int'l Joint Research
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[Presentation] Changes in the prevalence of airflow limitation in community-dwelling Japanese subjects: the Hisayama Study.<poster>2018
Author(s)
Ogata H, Hirakawa Y, Matsumoto K, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y
Organizer
ATS 2018, San Diego, CA, 2018.5
Related Report
Int'l Joint Research
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[Presentation] Serum NT-proBNP level is a useful biomarker for future dementia in a general Japanese elderly population: the Hisayama Study.<poster>2018
Author(s)
Nagata T, Ohara T, Honda T, Sakata S, Hata J, Hirakawa Y, Yoshida D, Shibata M, Ide T, Tsutsui H, Ninomiya T
Organizer
AHA Scientific Sessions 2018, Chicago, Illinois, 2018.11
Related Report
Int'l Joint Research
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