Cutaneous melanosis as a risk marker for alcohol-related cancer (baseline survey)
Project/Area Number |
17K09115
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Saga University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
島ノ江 千里 佐賀大学, 医学部, 特任准教授 (10734064)
杠 岳文 独立行政法人国立病院機構肥前精神医療センター(臨床研究部), 臨床研究部, 院長 (60182672)
原 俊哉 独立行政法人国立病院機構肥前精神医療センター(臨床研究部), 臨床研究部, 常勤医師 (70274602)
原 めぐみ 佐賀大学, 医学部, 准教授 (90336115)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | ALDH2 / 飲酒関連癌 / 遺伝子多型 / メラノーシス / バイオマーカー / 飲酒 / polymorphism / 癌予防 / ALDH2 polymorphism |
Outline of Final Research Achievements |
ALDH2 gene polymorphism (rs671) is possessed by about half of East Asians, has a high risk of drinking-related cancer but low susceptibility to liver damage. Therefore, warning of excessive drinking based on the levels of serum liver deviation enzyme is inappropriate. To propose a better marker of alcohol consumption, a baseline survey was conducted on 1,056 adults. Multiple regression analysis with adjustment for sun exposure scores and others showed a positive association between alcohol consumption and melanin deposition only in the rs671 carriers. A follow-up survey will be conducted to examine the relationship between melanin deposition and the development of alcohol-related cancer.
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Academic Significance and Societal Importance of the Research Achievements |
変異型ALDH2は飲酒習慣を抑制するため、日本では飲酒関連疾患が比較的少ない。ところが、飲酒関連癌はほぼ同数発生している。主な理由は、飲酒により発生するアセトアルデヒドの解毒が変異型ALDH2により遅れる事である。医療従事者は肝障害のない飲酒者に「飲酒OK」の判断を伝えてしまいがちだが、変異型ALDH2では血清AST, ALT, γGTPの上昇が少ないため、これに頼った判断は危険である。本研究でより適切なマーカーを示すことは、飲酒関連癌の予防に資する。
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Report
(4 results)
Research Products
(18 results)
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[Presentation] Alcohol-induced skin pigmentation: a novel phenotype of ALDH2 gene variant2018
Author(s)
Akiko Matsumoto, Shosuke Ito, Toshiya Hara, Kazumasa Wakamatsu, Tamio Suzuki, Yuko Abe, Chisato Shimanoe, Takefumi Yuzuriha, Chikako Yoshimori, Takeo Muto, Kouichi Endo, Megumi Hara, Masayoshi Ichiba, Vasilis Vasiliou, Byoung-Joon Song, Mayumi Fujita
Organizer
Carbonyl2018
Related Report
Int'l Joint Research
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[Presentation] A novel phenotype of ALDH2 polymorphism: alcohol-induced skin pigmentation.2018
Author(s)
Matsumoto A, Hara T, Shimanoe C, Yuzuriha T, Yoshimori C, Muto T, Endo K, Hara M, Ichiba M, Konakahara T, Yajima I, Vasiliou V, Song BJ, Fujita M.
Organizer
2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.
Related Report
Int'l Joint Research
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[Presentation] A novel phenotype of ALDH2 polymorphism: drinking-induced skin pigmentation.2017
Author(s)
Matsumoto A, Hara T, Shimanoe C, Yuzuriha T, Yoshimori C, Muto T, Endo K, Hara M, Ichiba M, Konakahara T, Yajima I, Vasiliou V, Song BJ, Fujita M.
Organizer
The International Pigment Cell Conference (IPCC) 2017
Related Report
Int'l Joint Research
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