Clinical study for new breast cancer screening to select breast examination by Breast density

• Project/Area Number: 17K09131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Showa University
• Principal Investigator: TERUMASA SAWADA 昭和大学, 医学部, 兼任講師 (80266105)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: マンモグラフィ検査 / 乳房超音波検査 / 乳房濃度 / ３次元乳房濃度測定ソフト / マンモグラフィ / 乳がん検診 / ボルパラ / 自動測定 / Dense Breast / 体表超音波検査 / Non dense Breast / 乳癌検診 / Volpara

Outline of Final Research Achievements

From 2013 to 2018, the total number of female aged 40 and over who underwent breast cancer screening in Shinagawa Ward was 53,439. We examined the effectiveness of combined MMG and US screening and whether breast cancer screening by breast density could be presented in the future.Of all 277cases of breast cancer with known breast densities, 54/277 (19.5%) had no abnormalities in MMG but breast cancer was found only in the US. Of these, the proportion of high-density breasts accounted for 75%.Non-dense breasts were 15 of 120 (12.5%), lower than the 19.5% above.
It was considered to be a suitable result for considering a new breast cancer screening method that utilizes the breast density obtained by mammography and selects the combination type for high-density breasts and MMG for non-high-density breasts.

Academic Significance and Societal Importance of the Research Achievements

東京都品川区の乳がん検診は、２年に一度のマンモグラフィ検査、もしくはマンモグラフィ検査 (MMG)に表超音波検査（US）を追加する併用型（追加料金1000円) 乳がん検診を行っている.
マンモグラフィ検査による乳房濃度別の検査を行うことができれば、高濃度乳房で、腫瘤が見えにくい乳房の女性には、エコー検査を追加し、非l高濃度乳房濃度であればエコー検査を省略する新しい乳癌検診を始めることができる。

Research Products

• [Journal Article] 乳がん診断における新しいモダリティと個別化検診乳棒濃度の重要性 (2018)
  • Author(s): 沢田晃暢
  • Journal Title: 日本がん検診、診断学会 Volume: 25 Pages: 155-159
  • Peer Reviewed
• [Journal Article] 乳がん診断における新しいモダリティと個別化検診乳房濃度の重要性 (2018)
  • Author(s): 沢田 晃暢
  • Journal Title: 日本がん検診、診断学会誌 Volume: 2 Pages: 155-159
  • Peer Reviewed / Open Access
• [Presentation] マンモ＋エコー併用型検診の（乳房濃度）結果から推測する今後の乳癌検診 (2020)
  • Author(s): 沢田晃暢
  • Organizer: 第２９回日本乳癌学会
• [Presentation] マンモグラフィ読影のmasking rateから比較する目視と３次元評価ソフトの優位性 (2019)
  • Author(s): 松柳美咲、沢田晃暢
  • Organizer: 第２７回乳癌学会総会
• [Presentation] Unique characteristics of the breast density(cancer,benign,screening) in Japanese women are clasified by using Volpara (2019)
  • Author(s): Terumasa Sawada
  • Organizer: 5th world congress on controversies in Breast Cancer
  • Int'l Joint Research
• [Presentation] 検診および乳癌症例から知る日本人乳房(濃度)の特長 (2018)
  • Author(s): 沢田晃暢
  • Organizer: 第28回日本乳癌学会
• [Presentation] THE BREAST CANCER RELATED-RISKS IN WOMEN WITH DENSE BREAST TISSUE IS CLARIFIED BY USING VOLPARATM (2018)
  • Author(s): TERUMASA SAWADA
  • Organizer: 4th World Congress onControversies in Breast Cancer (CoBrCa)
• [Presentation] 乳癌が乳房濃度に与える影響の検討 (2017)
  • Author(s): 沢田晃暢
  • Organizer: 第２５回日本乳癌学会
• [Presentation] 乳房濃度の重要性 (2017)
  • Author(s): 沢田晃暢
  • Organizer: 第27回日本乳癌検診学会