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Effect of shift work on platelet function - Aiming to reduce the risk of cardiovascular disease in shift workers

Research Project

Project/Area Number 17K09227
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical and hospital managemen
Research InstitutionThe University of Tokyo

Principal Investigator

Nakao Tomoko  東京大学, 医学部附属病院, 助教 (30597216)

Co-Investigator(Kenkyū-buntansha) 大門 雅夫  東京大学, 医学部附属病院, 講師 (80343094)
Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsshift work / platelete function / Thromboxane B2 / 夜間勤務 / トロンボキサンB2 / 血小板機能 / 血小板凝集能 / 血液型 / 可溶性ICAM-1 / 可溶性VCAM-1 / アラキドン酸代謝産物
Outline of Final Research Achievements

Shift work is associated with an increased risk of developing cardiovascular and cerebrovascular disorders. We investigated whether the activation of platelet function related to intravascular thrombus formation is affected by night shift work. We measured platelet function in 11 healthy medical workers twice, on the morning after the daytime shift and the morning after the nighttime shift. As indices of platelet function, platelet aggregation and serum arachidonic acid metabolite concentration (thromboxane B2, which is a metabolite of thromboxane A2 that causes strong platelet aggregation) were measured. After the night shift, there was a significant increase in serum arachidonic acid metabolites. This study indicates that night shifts may increase platelet sensitivity. We believe that this research will serve as a basis for obtaining knowledge about the appropriate frequency of night shifts, in order to optimize the working system of shift workers.

Academic Significance and Societal Importance of the Research Achievements

夜間勤務直後に血管内皮機能が低下することは過去に報告されていたが、血小板機能に対する夜間勤務の影響を検討した研究は、我々が知るところでは、本研究が初めてであった。本研究により、夜間勤務によって、血小板感受性が亢進する可能性が示された。本研究は、交代勤務者の勤務体系の適正化に向け、適正な夜間勤務の頻度などのついての知見を得るための基盤の研究となると考える。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (9 results)

  • [Journal Article] Asymptomatic Long-term Cardiac Perforation by a Pacemaker Lead2019

    • Author(s)
      Tomoko Nakao, Katsuhito Fujiu, Masae Uehara, Issei Komuro
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 16 Pages: 2409-2410

    • DOI

      10.2169/internalmedicine.1991-18

    • NAID

      130007690134

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-08-15
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thrombospondin-22019

    • Author(s)
      Tomoko Nakao, Hiroyuki Morita
    • Journal Title

      International Heart Journal

      Volume: 60 Issue: 2 Pages: 235-237

    • DOI

      10.1536/ihj.19-042

    • NAID

      130007617921

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-03-30
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of night-shift work on platelet function in healthy medical staff2018

    • Author(s)
      Tomoko Nakao, Atsushi Yasumoto, Suzumi Tokuoka, Yoshihiro Kita, Takuya Kawahara, Masao Daimon, Yutaka Yatomi
    • Journal Title

      Journal of Occupational Health

      Volume: 60 Issue: 4 Pages: 324-332

    • DOI

      10.1539/joh.2018-0027-FS

    • NAID

      130007418890

    • ISSN
      1341-9145, 1348-9585
    • Year and Date
      2018-07-20
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] アントラサイクリン系抗がん剤による心筋障害に対する心不全治療2022

    • Author(s)
      中尾倫子、大門雅夫、中西弘毅、木村公一、廣川愛美、澤田直子、石渡順平
    • Organizer
      日本超音波医学会第95回学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 拡張型心筋症における右室評価の意義2022

    • Author(s)
      中尾倫子、中西弘毅、木村公一、廣川愛美、澤田直子、石渡惇平、大門雅夫
    • Organizer
      日本超音波医学会第34回関東甲信越地方会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 左室心エコー指標の加齢変化における日米間差2022

    • Author(s)
      中尾倫子、竹内正明、矢冨裕、大門雅夫
    • Organizer
      第69回日本臨床検査医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 加齢によよるTxA2非依存性の血小板機能の低下:アスピリン投与中の虚血性心疾患患者における検討2021

    • Author(s)
      中尾倫子, 大門雅夫, 中西弘毅, 木村公一, 赤澤宏, 瀧本英樹, 武田憲文, 小室一成
    • Organizer
      第262回日本循環器学会関東甲信越地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] 全自動血液凝固測定装置CS-2400を用いた,抗血小板療法後の出血合併症予測の可能性2020

    • Author(s)
      中尾倫子、安本篤史、大門雅夫、小室一成、川手康徳、矢冨裕
    • Organizer
      第42回日本血栓止血学会
    • Related Report
      2020 Research-status Report
  • [Presentation] アスピリン投与中の虚血性心疾患患者における血小板凝集能に対する年齢の影響2020

    • Author(s)
      中尾 倫子、安本 篤史、大門 雅夫、井上 翔太、久保田 ともよ、千明 真弓、菅原 将代、鈴木 博英、西川 真子、矢冨 裕
    • Organizer
      第67回日本臨床検査医学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 頭蓋内髄膜腫術後に大動脈弁輪部に血栓を形成した一例2019

    • Author(s)
      谷口 寛,中尾 倫子,大門 雅夫,山内 治雄,小室 一成
    • Organizer
      第67回 日本心臓病学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 右室心筋が優位に障害された心サルコイドーシスの一症例2019

    • Author(s)
      中尾 倫子,大門 雅夫,井上 翔太,鈴木 博英,矢冨 裕
    • Organizer
      第66回 日本臨床検査医学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Nightshift work may lead to platelet hypersensitivity in healthy medical staffs.2017

    • Author(s)
      中尾 倫子、安本 篤史、大門 雅夫、矢冨 裕
    • Organizer
      第39回日本血栓止血学会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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