Mechanism of sarcopenia based on analysis of Werner syndrome
Project/Area Number |
17K09292
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Chiba University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
竹本 稔 千葉大学, 大学院医学研究院, 特任教授 (60447307)
前澤 善朗 千葉大学, 大学院医学研究院, 講師 (80436443)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 早老症 / サルコペニア / iPS細胞 / Werner症候群 / ウェルナー症候群 / WRN遺伝子 / 皮膚潰瘍 / 老化 |
Outline of Final Research Achievements |
Werner's syndrome (hereinafter, WS) is a hereditary progeria that prematurely causes aging signs such as gray hair, hair loss, cataracts and skin atrophy, diabetes and arteriosclerosis, and causes myocardial infarction and cancer after the age of 30. Since WS patients often exhibit strong sarcopenia, this study elucidated the mechanism of sarcopenia in WS patients. We established adipose tissue mesenchymal stem cells directly collected from WS patients. In addition, we established WS disease-specific iPS cells, and attempted to induce differentiation into mesenchymal stem cells. Then, it was found that WS-derived mesenchymal stem cells and WS-iPSC-derived mesenchymal stem cells exhibited signs of early senescence. In addition, differentiation into muscle cells is planned in the future.
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Academic Significance and Societal Importance of the Research Achievements |
サルコペニアは高齢者において転倒骨折、寝たきりやQOL低下の強いリスクである。本研究はヒト早老症の解析からヒトのサルコペニアの病態解明や治療開発に役立つ知見を得たいと考えており、サルコペニアの新たな治療戦略や治療薬開発への基盤となることが期待される。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome2019
Author(s)
Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Kato H, et al.
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Journal Title
Nature Communications
Volume: 10
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] R3hdml regulates satellite cell proliferation and differentiation2019
Author(s)
Sakamoto Kenichi、Furuichi Yasuro、Yamamoto Masashi、Takahashi Megumi、Akimoto Yoshihiro、Ishikawa Takahiro、Shimizu Takahiko、Fujimoto Masanori、Takada‐Watanabe Aki、Hayashi Aiko、Mita Yoshitaka、Manabe Yasuko、Fujii Nobuharu L、Ishibashi Ryoichi、Maezawa Yoshiro、Betsholtz Christer、Yokote Koutaro、Takemoto Minoru
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Journal Title
EMBO reports
Volume: 20
Issue: 11
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development2018
Author(s)
Ide S, Finer G, Maezawa Y, Onay T, Souma T, Scott R, Ide K, Akimoto Y, Li C,Ye M, Zhao X, Baba Y, Minamizuka T, Jin J, Takemoto M, Yokote K, Quaggin SE
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Journal Title
J Am Soc Nephrol
Volume: 29
Issue: 12
Pages: 2795-2808
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients2018
Author(s)
Maezawa Y, Kato H, Takemoto M, Watanabe A, Koshizaka M, Ishikawa T, Sargolzaeiaval F, Kuzuya M, Wakabayashi H, Kusaka T, Yokote K, Oshima J
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Journal Title
Mol Syndromol
Volume: 9
Issue: 4
Pages: 214-218
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immune-mediated acquired lecithin-cholesterol acyltransferase deficiency: A case report and literature review2018
Author(s)
Ishibashi R, Takemoto M, Tsurutani Y, Kuroda M, Ogawa M, Wakabayashi H, Uesugi N, Nagata M, Imai N, Hattori A, Sakamoto K, Kitamoto T, Maezawa Y, Narita I, Hiroi S, Furuta A, Miida T, Yokote K
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Journal Title
J Clin Lipidol
Volume: 12
Issue: 4
Pages: 888-897
DOI
Related Report
Peer Reviewed
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[Presentation] 細胞老化を認めたにも関わらず、難治性皮膚潰瘍を著明に改善し得たWerner症候群の1例2018
Author(s)
木下大輔, 金子ひより, 加藤尚也, 石川崇広, 越坂理也, 前澤善朗, 緒方英之, 窪田吉孝, 三川信之, 横手幸太郎
Organizer
日本老年医学会関東甲信越地方会第68回大会,
Related Report
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[Presentation] Recapitulation of premature senescence and tumor predisposition phenotype in Werner syndrome specific iPSCs2018
Author(s)
Hisaya Kato, Yoshiro Maezawa, Yasuo Ouchi, Naoyo Takayama, Masamitsu Sone, Takahiro Ishikawa, Masaya Koshizaka, Katsunori Fujii, Atsushi Iwama, Koji Eto, Akira Shimamoto, Hidetoshi Tahara, Koutaro Yokote
Organizer
International symposium on RECQ Helicases and Related Diseases 2018
Related Report
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