Regulation of lipid-reactive lymphocytes for IBD treatment

• Project/Area Number: 17K09372
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: FUJII Toshimitsu 東京医科歯科大学, 医学部附属病院, 助教 (30547451)
• Co-Investigator(Kenkyū-buntansha): 永石 宇司 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (60447464) ; 渡辺 守 東京医科歯科大学, 高等研究院, 特別栄誉教授 (10175127)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 免疫 / 腸管免疫 / 消化器病学 / 炎症性腸疾患

Outline of Final Research Achievements

Inflammatory bowel disease (IBD) is characterized by unrestrained lymphocyte activation that results in the production of a variety of pro-inflammatory cytokines as well as other mediators. Understanding the mechanisms of lymphocyte regulation is therefore of significant importance in the study of dysregulated mucosal inflammation such as IBD. Associated with this, several studies have revealed the importance of lipid-reactive lymphocyte populations, such as natural killer T cells, in IBD pathology. In this regards, we were able to observe ex vivo activities where proliferation of these lymphocytes can be modulated by intestinal epithelial cells derived from mouse tissues. Defining the physiological mechanisms of intestinal epithelial cells will lead to a significant understanding of the manner in which manipulation of lipid-reactive lymphocyte function may provide insights into novel therapeutic methods for the treatment of IBD.

Academic Significance and Societal Importance of the Research Achievements

炎症性腸疾患(IBD)の新規治療法開発を困難にしている理由は、腸管の免疫調節機構が未だ不明確であることにある。本研究の意義は腸管の粘膜免疫応答に関する研究を展開してきた申請者らが、マウス腸管組織由来の上皮細胞初代培養技術を応用しつつ腸管特有の免疫調節機構を繙くことで、これまで実現し得なかった「脂質に対する粘膜免疫応答」の機能解析に向けた技術基盤を樹立するという免疫学的貢献ばかりでなく、IBDにおける腸管粘膜傷害に対するその特異的な免疫調節異常を標的とした新規細胞治療、分子治療開発へ向けた理論、技術基盤の創出に発展するものと期待できる。

Research Products

• [Journal Article] Development and validation of a deep neural network for accurate evaluation of endoscopic images from patients with ulcerative colitis. (2020)
  • Author(s): Kento Takenaka , Kazuo Ohtsuka , Toshimitsu Fujii , Mariko Negi , Kohei Suzuki , Hiromichi Shimizu , Shiori Oshima , Shintaro Akiyama , Maiko Motobayashi , Masakazu Nagahori , Eiko Saito , Katsuyoshi Matsuoka , Mamoru Watanabe
  • Journal Title: Gastroenterology Volume: Epub ahead of print Issue: 8 Pages: 2150-2157
  • DOI: 10.1053/j.gastro.2020.02.012
  • Peer Reviewed
• [Journal Article] CD8αα+ T cells show amoeboid shape and frequent morphological change in?vitro, and localize to small intestinal intraepithelial region in?vivo (2020)
  • Author(s): Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 523 Issue: 2 Pages: 328-335
  • DOI: 10.1016/j.bbrc.2019.12.021
  • Peer Reviewed / Open Access
• [Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage (2020)
  • Author(s): Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 522 Issue: 4 Pages: 971-977
  • DOI: 10.1016/j.bbrc.2019.11.158
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. (2020)
  • Author(s): Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
  • Journal Title: FEBS letters Volume: 594 Issue: 10 Pages: 1586-1595
  • DOI: 10.1002/1873-3468.13748
  • Peer Reviewed / Open Access
• [Journal Article] Indolent T cell lymphoproliferative disorder with villous atrophy in small intestinediagnosed by single-balloon enteroscopy. (2019)
  • Author(s): Takashi Nagaishi, Daiki Yamada, Kohei Suzuki, Ryosuke Fukuyo, Eiko Saito, Masayoshi Fukuda, Taro Watabe, Naoya Tsugawa, Kengo Takeuchi, Kouhei Yamamoto, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe
  • Journal Title: Clin J Gastroenterol. Volume: in press Issue: 5 Pages: 434-440
  • DOI: 10.1007/s12328-019-00971-1
  • Peer Reviewed / Open Access
• [Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor (2019)
  • Author(s): Takenaka Kento、Fujii Toshimitsu、Suzuki Kohei、Shimizu Hiromichi、Motobayashi Maiko、Hibiya Shuji、Saito Eiko、Nagahori Masakazu、Watanabe Mamoru、Ohtsuka Kazuo
  • Journal Title: Clinical Gastroenterology and Hepatology Volume: inpress Issue: 7 Pages: 1545-1552
  • DOI: 10.1016/j.cgh.2019.08.024
  • Peer Reviewed / Open Access
• [Journal Article] Crohn Disease: A 5-Point MR Enterocolonography Classification Using Enteroscopic Findings (2019)
  • Author(s): Kitazume Yoshio、Fujioka Tomoyuki、Takenaka Kento、Oyama Jun、Ohtsuka Kazuo、Fujii Toshimitsu、Tateisi Ukihide
  • Journal Title: American Journal of Roentgenology Volume: 212 Issue: 1 Pages: 67-76
  • DOI: 10.2214/ajr.17.18897
  • Peer Reviewed
• [Journal Article] Predictors of mucosal healing during induction therapy in patients with acute moderate‐to‐severe ulcerative colitis (2018)
  • Author(s): Motobayashi Maiko、Matsuoka Katsuyoshi、Takenaka Kento、Fujii Toshimitsu、Nagahori Masakazu、Ohtsuka Kazuo、Iwamoto Fumihiko、Tsuchiya Kiichiro、Negi Mariko、Eishi Yoshinobu、Watanabe Mamoru
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: in press Issue: 6 Pages: 1004-1010
  • DOI: 10.1111/jgh.14565
  • Peer Reviewed
• [Journal Article] Long‐term retention of adalimumab treatment and associated prognostic factors for 1189 patients with Crohn's disease. (2018)
  • Author(s): Hiroki Tanaka Noriko Kamata Akihiro Yamada Katsuya Endo Toshimitsu Fujii Takuya Yoshino Takeshi Sugaya Yoko Yokoyama Shigeki Bamba Junji Umeno Yuka Yanai Manabu Ishii Takaaki Kawaguchi Shinichiro Shinzaki Yosuke Toya Taku Kobayashi Masanori Nojima Toshifumi Hibi The ADJUST study group.
  • Journal Title: J Gastroenterol Hepatol. Volume: 33 Issue: 5 Pages: 1031-1038
  • DOI: 10.1111/jgh.14034
  • Peer Reviewed
• [Journal Article] Prediction of disease activity of Crohn's disease through fecal calprotectin evaluated by balloon‐assisted endoscopy (2018)
  • Author(s): Iwamoto Fumihiko、Matsuoka Katsuyoshi、Motobayashi Maiko、Takenaka Kento、Kuno Toru、Tanaka Keisuke、Tsukui Yuya、Kobayashi Shoji、Yoshida Takashi、Fujii Toshimitsu、Saito Eiko、Yamaguchi Tatsuya、Nagahori Masakazu、Sato Tadashi、Ohtsuka Kazuo、Enomoto Nobuyuki、Watanabe Mamoru
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 33 Issue: 12 Pages: 1984-1989
  • DOI: 10.1111/jgh.14310
  • Peer Reviewed
• [Journal Article] Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease. (2018)
  • Author(s): Shinichiro Shinzaki, Toshimitsu Fujii, Shigeki Bamba, Maiko Ogawa, et al.
  • Journal Title: Intestinal Research. Volume: 16 Issue: 4 Pages: 609-618
  • DOI: 10.5217/ir.2018.00044
  • Peer Reviewed
• [Journal Article] Risk Factors for Mortality in Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease. (2018)
  • Author(s): Atsushi Yoshida Noriko Kamata Akihiro Yamada Yoko Yokoyama Teppei Omori Toshimitsu Fujii Ryohei Hayashi Tetsu Kinjo Akira Matsui Norimasa Fukata Sakuma Takahashi Ryosuke Sakemi Noriyuki Ogata Shinya Ashizuka Shigeki Bamba Makoto Ooi Shuji Kanmura Katsuya Endo et al.
  • Journal Title: Inflamm Intest Dis. Volume: 3 Issue: 4 Pages: 167-172
  • DOI: 10.1159/000495035
  • Peer Reviewed
• [Journal Article] B cell activation in the cecal patches during the development of an experimental colitis model. (2018)
  • Author(s): Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
  • Journal Title: Biochem Biophys Res Commun. Volume: 496 Issue: 2 Pages: 367-373
  • DOI: 10.1016/j.bbrc.2018.01.053
  • Peer Reviewed / Open Access
• [Journal Article] 【特集】IBD治療薬の最適化とは？ IBD治療におけるカルシニューリン阻害薬の最適化 (2018)
  • Author(s): 藤井俊光
  • Journal Title: IBD Research Volume: 12 Pages: 32-36
• [Journal Article] 【特集】クローン病の最新薬物療法 クローン病のステロイド治療 ープレドニゾロン、ブデソニドの使い方 (2018)
  • Author(s): 藤井俊光、渡辺 守
  • Journal Title: 消化器の臨床 Volume: 21 Pages: 19-26
• [Journal Article] 小腸病変の評価法：内視鏡とほかのモダリティーの比較 (2018)
  • Author(s): 竹中健人、大塚和朗、鈴木康平、勝倉暢洋、福田将義、藤井俊光、齊藤詠子、本林麻衣子、松岡克善、長堀正和、北詰良雄、藤岡友之、渡辺 守
  • Journal Title: 胃と腸 Volume: 53 Pages: 203-210
• [Journal Article] 特集Ⅰ 潰瘍性大腸炎－診断治療のアップデート 潰瘍性大腸炎の病因・疫学 (2018)
  • Author(s): 藤井俊光、渡辺 守
  • Journal Title: 消化器・肝臓内科 Volume: 3 Pages: 1-7
• [Journal Article] 【特集】コモンな難病 炎症性腸疾患の薬物療法 IBD治療薬の選び方、使い方. 新規治療法 (2018)
  • Author(s): 藤井俊光
  • Journal Title: 月刊 薬事 Volume: 60 Pages: 58-65
• [Journal Article] Utility of Magnetic Resonance Enterography For Small Bowel Endoscopic Healing in Patients With Crohn’s Disease (2017)
  • Author(s): Takenaka Kento、Ohtsuka Kazuo、Kitazume Yoshio、Matsuoka Katsuyoshi、Nagahori Masakazu、Fujii Toshimitsu、Saito Eiko、Kimura Maiko、Fujioka Tomoyuki、Watanabe Mamoru
  • Journal Title: The American Journal of Gastroenterology Volume: 113 Issue: 2 Pages: 283-294
  • DOI: 10.1038/ajg.2017.464
  • Peer Reviewed
• [Journal Article] Real-world Experience of Anti-tumor Necrosis Factor Therapy for Internal Fistulas in Crohn's Disease: A Retrospective Multicenter Cohort Study. (2017)
  • Author(s): Kobayashi T, Hishida A, Tanaka H, Nuki Y, Bamba S, Yamada A, Fujii T, Shinzaki S, Yokoyama Y, Yoshida A, Ozeki K, Ashizuka S, Kamata N, Nanjo S, Kakimoto K, Nakamura M, Matsui A, Yamauchi R, Takahashi S, Tomizawa T, Yoshino T, Hibi T.
  • Journal Title: Inflamm Bowel Dis. Volume: 23 Issue: 12 Pages: 2245-2251
  • DOI: 10.1097/mib.0000000000001276
  • Peer Reviewed
• [Journal Article] Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy. (2017)
  • Author(s): Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Katsuyoshi Matsuoka, Toshimitsu Fujii, Masakazu Nagahori, Maiko Kimura, Tomoyuki Fujioka, Akihiro Araki, Mamoru Watanabe.
  • Journal Title: J. Gastroenterol. Volume: 52 Issue: 8 Pages: 879-888
  • DOI: 10.1007/s00535-016-1284-z
  • Peer Reviewed
• [Journal Article] Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis. (2017)
  • Author(s): Akiyama S, Fujii T, Matsuoka K, Yusuke E, Negi M, Takenaka K, Nagahori M, Ohtsuka K, Isobe M, Watanabe M.
  • Journal Title: J Gastroenterol Hepatol. Volume: 32 Issue: 5 Pages: 1011-1017
  • DOI: 10.1111/jgh.13640
  • Peer Reviewed
• [Journal Article] MKL1 expressed in macrophages contributes to the development of murine colitis. (2017)
  • Author(s): Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 13650-13650
  • DOI: 10.1038/s41598-017-13629-0
  • Peer Reviewed / Open Access
• [Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by p62/SQSTM1. (2017)
  • Author(s): Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
  • Journal Title: Autophagy. Volume: 22 Issue: 2 Pages: 1-43
  • DOI: 10.1080/15548627.2017.1407889
  • Peer Reviewed / Open Access
• [Journal Article] IL-7 Biology- IL-7による腸管粘膜の免疫調節と大腸炎. (2017)
  • Author(s): 永石宇司、渡辺 守
  • Journal Title: 医学のあゆみ. Volume: 261 Pages: 1083-1087
• [Journal Article] 消化管病変の免疫応答制御に向けた新たな戦略. (2017)
  • Author(s): 永石宇司
  • Journal Title: 消化器と免疫 News letter. Volume: 18 Pages: 2-3
• [Journal Article] クローン病感受性遺伝子 ”TNFAIP3・XIAP遺伝子”. (2017)
  • Author(s): 鬼沢道夫、永石宇司、浅川剛人、南舘 愛、渡辺 守
  • Journal Title: 臨床免疫・アレルギー科. Volume: 68 Pages: 351-356
• [Presentation] B cell receptor signaling in lymphoid tissues may be regulated by CEACAM1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Mamoru Watanabe.
  • Organizer: European Crohn’s and Colitis Organization 2020
  • Int'l Joint Research
• [Presentation] IBDモデルにおける腸管二次リンパ組織の機能解析. (2020)
  • Author(s): 永石宇司、渡部太郎、渡辺 守.
  • Organizer: 日本応用酵素協会「全身性炎症疾患の病因・病態に関する研究助成」 第9回研究発表会
• [Presentation] IgA-deficiency causes spontaneous enteritis. (2019)
  • Author(s): Takahiro Adachi, Taro Watabe, Takashi Nagaishi, Mamoru Watanabe, Hajime Karasuyama, Soichiro Yoshikawa.
  • Organizer: 第48回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] BCR signaling in the activated B cells may be regulated by the long isoform of Ceacam1. (2019)
  • Author(s): Naoya Tsugawa, Takashi Nagaishi, Daiki Yamada, Yudai Kojima, Taro Watabe, Shuang Wang, Michio Onizawa, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: 第48回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] 培養腸上皮幹細胞を用いた炎症性腸疾患に対する再生医療の開発. (2019)
  • Author(s): 岡本隆一、清水寛路、鈴木康平、高橋純一、川井麻央、平栗優衣、竹岡さや香、杉原ハディ優樹、永田紗矢香、竹中健人、齋藤詠子、福田将義、藤井俊光、長堀正和、油井史郎、土屋輝一郎、大塚和朗、渡辺 守
  • Organizer: 厚生労働科学研究費 難治性疾患政策研究事業 「難治性炎症性腸管障害に関する調査研究」令和元年度 第1回総会
• [Presentation] Analysis of ileocecal immune response in an animal model of colitis. (2019)
  • Author(s): Daiki Yamada, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Yudai Kojima,Nisha Jose, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: International Congress of Mucosal Immunology 2019
  • Int'l Joint Research
• [Presentation] Analysis of APL expression in an animal model of chronic colitis. (2019)
  • Author(s): Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Daiki Yamada, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
  • Organizer: Federation of Clinical Immunology Societies 2019
  • Int'l Joint Research
• [Presentation] APL downregulation in an animal model of chronic colitis. (2019)
  • Author(s): Daiki Yamada, Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
  • Organizer: Asian Organization of Crohn’s and Colitis 2019
  • Int'l Joint Research
• [Presentation] Small bowel endoscopic healing of Crohn’s disease treated with anti-TNF antibodies. (2019)
  • Author(s): Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe
  • Organizer: Asian Organization of Crohn’s and Colitis 2019
  • Int'l Joint Research
• [Presentation] The clinical efficacy of ustekinumab (UST) in patients with Crohn’s disease (CD). (2019)
  • Author(s): Eiko Saito, Kohei Suzuki, Shuji Hibiya, Maiko Motobayashi, Kento Takenaka, Nobukatsu Horita, Hiromichi Shimizu, Michio Onizawa, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Organizer: Asian Organization of Crohn’s and Colitis 2019
  • Int'l Joint Research
• [Presentation] APL expression is downregulated in an animal model of chronic colitis. (2019)
  • Author(s): Takashi Nagaishi, Yudai Kojima, Daiki Yamada, Taro Watabe, Naoya Tsugawa, Nisha Jose, Michio Onizawa, Mamoru Watanabe.
  • Organizer: European Crohn’s and Colitis Organization 2019
  • Int'l Joint Research
• [Presentation] intra-vital imagingによる実験腸炎モデル回盲部免疫応答の解析. (2018)
  • Author(s): 渡部太郎、永石宇司、細谷明徳、Jose, Nisha、津川直也、小島裕大、安達貴弘、渡辺 守.
  • Organizer: 第104回日本消化器病学会総会
• [Presentation] Analysis of ileocecal immune response in an animal model of colitis using intra-vital imaging. (2018)
  • Author(s): Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe
  • Organizer: Digestive Disease Week 2018
  • Int'l Joint Research
• [Presentation] Mice overexpressing MKL1 in macrophages are susceptible to the development of colitis. (2018)
  • Author(s): Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura
  • Organizer: Digestive Disease Week 2018
  • Int'l Joint Research
• [Presentation] Analysis of cecal immune response in a murine model of colitis using intravital imaging. (2018)
  • Author(s): Takashi Nagaishi, Taro Watabe, Tsugawa, Yudai Kojima, Nisha Jose, Daiki Yamada, Takahiro Adachi, Mamoru Watanabe
  • Organizer: Federation of Clinical Immunology Societies 2018
  • Int'l Joint Research
• [Presentation] Mice overexpressing MKL1 in macrophages are susceptible to DSS-induced colitis. (2018)
  • Author(s): Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura
  • Organizer: Federation of Clinical Immunology Societies 2018
  • Int'l Joint Research
• [Presentation] Overexpression of MKL1 in Macrophages leads to the development of murine colitis. (2018)
  • Author(s): Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura.
  • Organizer: Mucosal Immunology Course and Symposium 2018
  • Int'l Joint Research
• [Presentation] B cell-mediated ileocecal immune response is activated in the early phase of colitis development. (2018)
  • Author(s): Yudai Kojima, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Nisha Jose, Daiki Yamada, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: United European Gastroenterology Week 2018
  • Int'l Joint Research
• [Presentation] Mice overexpressing MKL1 in macrophages experience fulminant colitis. (2018)
  • Author(s): Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura.
  • Organizer: United European Gastroenterology Week 2018
  • Int'l Joint Research
• [Presentation] Downregulated APL expression in T cells in the setting of chronic colitis. (2018)
  • Author(s): Yudai Kojima, Takashi Nagaishi, Taro Watabe, Daiki Yamada, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] Verification of intestinal microflora-mediated mucosal homeostasis by immunoglobulin A. (2018)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: The 11th International Gastrointestinal Consensus Symposium
  • Int'l Joint Research
• [Presentation] IgAによる腸内細菌叢制御と腸管粘膜防御の検証. (2018)
  • Author(s): 津川直也、永石宇司、渡部太郎、細谷明徳、Jose, Nisha、小島裕大、安達貴弘、渡辺 守.
  • Organizer: 第14回日本消化管学会総会学術集会
• [Presentation] MAIT cells exacerbate the disease course of oxazolone colitis. (2017)
  • Author(s): Asako Chiba, Masato Kamei, Takashi Nagaishi, Keiichi Haga, Sachiko Miyake.
  • Organizer: 第46回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] Verification of immunoglobulin A regulation of mucosal microflora and homeostasis. (2017)
  • Author(s): Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: 第46回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging. (2017)
  • Author(s): Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Naoya Tsugawa, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: 第46回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] MAIT cells exacerbate the disease course of oxazolone-induced colitis. (2017)
  • Author(s): Asako Chiba, Takashi Nagaishi, Sachiko Miyake.
  • Organizer: CD1-MR1 2017
  • Int'l Joint Research
• [Presentation] Verification of immunoglobulin A regulation of microflora and protection of intestinal mucosa. (2017)
  • Author(s): Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Takahiro Adachi, Richard S. Blumberg, Mamoru Watanabe.
  • Organizer: United European Gastroenterology Week 2017
  • Int'l Joint Research
• [Presentation] 炎症性腸疾患の病態形成におけるMKL1の役割. (2017)
  • Author(s): 安健博、永石宇司、渡部太郎、成瀬妙子、渡辺守、木村彰方.
  • Organizer: 第26回日本組織適合性学会大会
• [Presentation] IgA欠損による腸内細菌叢制御の破綻と回腸粘膜傷害の誘発. (2017)
  • Author(s): 渡部太郎、永石宇司、津川直也、Jose, Nisha、細谷明徳、小島裕大、安達貴弘、渡辺守.
  • Organizer: 第55回日本小腸学会学術集会
• [Presentation] 免疫グロブリンAによる腸内細菌叢調節と腸管粘膜防御の再検証. (2017)
  • Author(s): 津川直也、永石宇司、渡部太郎、Jose, Nisha、細谷明徳、小島裕大、安達貴弘、渡辺守
  • Organizer: 第54回日本消化器免疫学会総会
• [Presentation] 回腸粘膜における防御機構としてのIgAの重要性. (2017)
  • Author(s): 渡部太郎、永石宇司、津川直也、Jose, Nisha、細谷明徳、小島裕大、安達貴弘、渡辺守.
  • Organizer: 第45回日本臨床免疫学会総会
• [Presentation] 生体イメージングを応用したIBDモデルにおける腸管粘膜免疫応答の解析. (2017)
  • Author(s): 永石宇司、渡部太郎、細谷明徳、Jose, Nisha、津川直也、小島裕大、安達貴弘、渡辺守.
  • Organizer: 第45回日本臨床免疫学会総会
  • Invited
• [Presentation] Deficiency of IgA induces microflora alteration and ileal inflammation. (2017)
  • Author(s): Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: International Congress of Mucosal Immunology 2017
  • Int'l Joint Research
• [Presentation] Verification of immunoglobulin A protection of intestinal mucosa from microflora. (2017)
  • Author(s): Akinori Hosoya, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: The 5th Annual Meeting of Asian Organization of Crohn’s & Colitis
  • Int'l Joint Research
• [Presentation] IgA deficiency induces spontaneous inflammation in the ileum. (2017)
  • Author(s): Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: Federation of Clinical Immunology Societies 2017
  • Int'l Joint Research
• [Presentation] The lack of secreted IgA spontaneously induces the mucosal inflammation specifically in the ileum. (2017)
  • Author(s): Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Arisa Tokai, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: Digestive Disease Week 2017
  • Int'l Joint Research
• [Presentation] 潰瘍性大腸炎モデルマウスにおけるMAIT細胞の関与. (2017)
  • Author(s): 亀井將人、千葉麻子、永石宇司、芳賀慶一、三宅幸子.
  • Organizer: 第103回日本消化器病学会総会
• [Presentation] IgA欠損による回腸粘膜傷害の誘発. (2017)
  • Author(s): 渡部太郎、永石宇司、Jose Nisha、東海有沙、細谷明徳、小島裕大、安達貴弘、渡辺守.
  • Organizer: 第103回日本消化器病学会総会
• [Book] Crohn’s Disease and Ulcerative Colitis: from Epidemiology and Immunology to a Rational Diagnostic and Therapeutic Approach (2017)
  • Author(s): Nagaishi T and Watanabe M
  • Publisher: Springer, New York
  • ISBN: 9783319337012
• [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物 (2019)
  • Inventor(s): 永石宇司
  • Industrial Property Rights Holder: 永石宇司
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物 (2017)
  • Inventor(s): 永石宇司、渡辺守、久場敬司
  • Industrial Property Rights Holder: 東京医科歯科大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas