Regulation of Hepatitis B Virus-Specific T Cell Responses by Innate Immune Response
| Project/Area Number |
17K09436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Isogawa Masanori 名古屋市立大学, 医薬学総合研究院(医学), 講師 (50723201)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | B型肝炎ウイルス / CD8＋T細胞 / 自然免疫 / HBV / IFN / CD8+T細胞 / T細胞 / インターフェロン / T細胞応答 |
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| Outline of Final Research Achievements |
In this study, we investigated the role of type I interferon (IFN) in the induction of HBV-specific CD8 + T cell responses. In a transient HBV infection model, we showed that type I IFN indirectly attenuates HBV-specific CD8 + T cell response by suppressing the amount of antigen in the early stage of HBV transduction. On the other hand, in the persistent HBV infection model, we showed that antigen recognition in the liver suppresses the type I IFN signal in CD8 + T cells, and that its activation is extremely important for the induction of T cell proliferation and functionality
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| Academic Significance and Societal Importance of the Research Achievements |
全世界でおよそ2億5千万人がHBVに持続感染しており、肝細胞癌へと進行するリスクにさらされている。HBVの排除にはHBV特異的CD8+T細胞応答が必要不可欠である。I型IFNがHBV特異的CD8+T細胞に及ぼす影響はほとんど理解されておらず、本研究は学術的に極めて意義深い。さらに、T細胞内のI型IFNシグナルを活性化することでT細胞の増殖と機能性の誘導ができるという成果は、B型慢性肝炎に対する新たな治療法の確立に役立つと考えられ、その社会的意義も非常に大きい。
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People2018
Author(s)
Hayashi Sanae, Khan Anis, Simons Brenna C., Homan Chriss, Matsui Takeshi, Ogawa Kenji, Kawashima Keigo, Murakami Shuko, Takahashi Satoru, Isogawa Masanori, Ikeo Kazuho, Mizokami Masashi, McMahon Brian J., Tanaka Yasuhito
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Journal Title
Hepatology
Volume: 69 (1)
Issue: 1
Pages: 19-33
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] A Novel Association Between Core Mutations in Hepatitis B Virus Genotype F1b and HCC in Alaskan Native People2018
Author(s)
Hayashi S, Khan A, Simons BC, Homan C, Matsui T, Ogawa K, Kawashima K, Murakami S, Takahashi S, Isogawa M, Ikeo K, Mizokami M, McMahon BJ, Tanaka Y
Organizer
APASL Single Topic Conference on HCC
Related Report
Int'l Joint Research
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