Target therapy for cancer-associated fibroblast in pancreatic cancer

• Project/Area Number: 17K09469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Abue Makoto 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (50599967)
• Co-Investigator(Kenkyū-buntansha): 佐藤 賢一 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055) ; 玉井 恵一 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (40509262)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 膵癌 / がん幹細胞

Outline of Final Research Achievements

Pancreatic cancer is a life-threatening disease and resistant to conventional therapy. Our goal is to determine the new therapeutic target in pancreatic cancer. We analyzed the relationship between tumor cells and microenvironment and found that CD109 is a key player. We demonstrated that CD109 plays critical roles in tumorigenicity and migration capacity, and is associated with distant metastasis.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果、膵癌の、特に遠隔転移に関係するあらたな分子を同定することができた。将来的な治療標的につながる成果である。

Research Products

• [Journal Article] BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma (2020)
  • Author(s): Tamai Keiichi、Nakamura-Shima Mao、Shibuya-Takahashi Rie、Kanno Shin-Ichiro、Yasui Akira、Mochizuki Mai、Iwai Wataru、Wakui Yuta、Abue Makoto、Yamamoto Kuniharu、Miura Koh、Mizuma Masamichi、Unno Michiaki、Kawamura Sadafumi、Sato Ikuro、Yasuda Jun、Yamaguchi Kazunori、Sugamura Kazuo、Satoh Kennichi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 21592-21592
  • DOI: 10.1038/s41598-020-78539-0
  • Peer Reviewed / Open Access
• [Journal Article] CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells (2020)
  • Author(s): Hatsuzawa Yuuri、Yamaguchi Kazunori、Takanashi Tomoka、Sato Ikuro、Tamai Keiichi、Mochizuki Mai、Iwai Wataru、Wakui Yuta、Abue Makoto、Yamamoto Kuniharu、Yasuda Jun、Mizuma Masamichi、Unno Michiaki、Sugamura Kazuo
  • Journal Title: Pancreatology Volume: 20 Issue: 3 Pages: 493-500
  • DOI: 10.1016/j.pan.2020.01.013
  • Peer Reviewed