Noninvasive Mapping of Premature Ventricular Contractions by Merging Magnetocardiography and Computed Tomography.

• Project/Area Number: 17K09484
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: University of Tsukuba
• Principal Investigator: Yoshida Kentaro 筑波大学, 医学医療系, 准教授 (30582861)
• Co-Investigator(Kenkyū-buntansha): 野上 昭彦 筑波大学, 医学医療系, 教授 (80708602)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 心室期外収縮 / カテーテルアブレーション / 心磁図 / アブレーション / 内科

Outline of Final Research Achievements

Electrocardiography can noninvasively identify the origins of premature ventricular contractions (PVCs). However, its accuracy is limited due to its low spatial resolution. This study aimed to develop a novel PVC mapping method to predict PVC origins in whole ventricles by merging a magnetocardiography (MCG) image with a cardiac computed tomography (CT) image. Estimated origins by MCG-CT imaging matched the origins determined during the procedure in 94% (17 of 18) of patients. The diagnostic accuracy of noninvasive MCG-CT mapping was high enough to allow clinical use to predict the site of PVC origins in the whole ventricles.

Academic Significance and Societal Importance of the Research Achievements

一部の心室期外収縮においてはカテーテルアブレーション治療による根治率が低いことが知られている。不整脈発生源が心臓の外側にあったり、心室壁の深層に存在していると、通電エネルギーが不整脈源に届かずに、通電効果が及ばないためである。我々が開発した3次元マッピングを用いることで、これら難治性不整脈を術前に診断することが可能となる。患者に予測される成功率、危険性を術前に詳しく情報提供することが可能となり、さらに治療の方法を前もって策定することで、治療の効果、効率、安全性を向上させることができると考えられる。

Research Products

• [Journal Article] Noninvasive Mapping of Premature Ventricular Contractions by Merging Magnetocardiography and Computed Tomography (2019)
  • Author(s): Aita S, Ogata K, Yoshida K, Inaba T, Kosuge H, Machino T, Tsumagari Y, Hattori A, Ito Y, Komatsu Y, Sekihara K, Horigome H, Aonuma K, Nogami A, Kandori A, Ieda M
  • Journal Title: JACC: Clinical Electrophysiology Volume: 5 Issue: 10 Pages: 1144-1157
  • DOI: 10.1016/j.jacep.2019.06.010
  • Peer Reviewed / Open Access
• [Presentation] 心磁図‐CT合成画像を用いた非侵襲的心室不整脈起源同定法の評価 (2019)
  • Author(s): 吉田健太郎
  • Organizer: 第３９回日本ホルター・ノンインベイシブ心電学研究会
• [Presentation] 心室性期外収縮に対する心磁図と3次元CT画像の合成による非侵襲的マッピング法 (2019)
  • Author(s): 會田敏
  • Organizer: 日本生体磁気学会
• [Presentation] Non-invasive mapping for premature ventricular contractions by means of merging a magnetocardiographic image with a three-dimensional computed tomography image (2018)
  • Author(s): Satoshi Aita
  • Organizer: American Heart Association, Scientific Session 2018
  • Int'l Joint Research
• [Presentation] Non-invasive magnetocardiographic mapping merged with 3-dimensional computed tomography in patients with ventricular arrhythmias (2017)
  • Author(s): Aita Satoshi
  • Organizer: Biomagnetic Sendai 2017
  • Int'l Joint Research
• [Remarks] 不整脈の発生部位を高い精度で特定 ～心磁図と心臓CT画像の合成技術を用いて～
  • URL: http://www.tsukuba.ac.jp/attention-research/p201908010300.html