| Project/Area Number |
17K09494
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hiroshima University (2019)
Shiga University of Medical Science (2017-2018) |
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Principal Investigator |
Itoh Hideki 広島大学, 病院(医), 教授 (30402738)
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| Co-Investigator(Kenkyū-buntansha) |
大野 聖子 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (20610025)
松浦 博 滋賀医科大学, 医学部, 教授 (60238962)
堀江 稔 滋賀医科大学, アジア疫学研究センター, 特任教授 (90183938)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 個別化医療 / 突然死 / 薬剤 / 遺伝子 / QT延長 / QT延長症候群 / 薬剤性 / 多型 / 後天性 |
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| Outline of Final Research Achievements |
This study revealed that patients with drug-induced QT prolongation and/or fatal arrhythmias failed to carry a mutation in minor candidate genes corresponding to congenital long QT syndrome. The frequency of polymorphisms in CYP genes were similar between drug-induced long QT syndrome and normal control cohorts. We are able to establish the risk stratification based on the underlying genetics including LQT1-LQT3, QT interval at baseline, gender and age upon this study.
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| Academic Significance and Societal Importance of the Research Achievements |
薬剤性QT延長症候群の遺伝的背景に、5つの責任遺伝子(KCNQ1:LQT1, KCNH2:LTQ2, SCN5A:LQT3, KCNE1:LQT5, KCNE2:LQT6)以外のminor geneはcontributionが小さいことが明らかになった。薬剤性QT延長症候群の予防・管理においては、保険診療として実施しうるLQT1-3の3つのサブタイプの有無とQT間隔、性別・年齢等を加味した、risk stratificationの構築が実用的であることが示された。
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