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Electrocardiographic score system for patients with adult congenital heart disease

Research Project

Project/Area Number 17K09499
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionOkayama University

Principal Investigator

WATANABE ATSUYUKI  岡山大学, 大学病院, 講師 (50766441)

Co-Investigator(Kenkyū-buntansha) 森田 宏  岡山大学, 医歯薬学総合研究科, 教授 (50322227)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords致死性不整脈 / スコアリング / 成人先天性心疾患 / 予後予測 / スコアリング化 / 不整脈 / MACE / 心電図指標 / 経皮的カテーテル心筋焼灼術 / 予後 / 先天性心疾患 / 心臓突然死 / 心不全 / 心血管イベント
Outline of Final Research Achievements

We investigated the electrocardiographic prognostic factors in cases with underlying heart disease. We tried to make a more accurate system construction by combining multiple factors and scoring. Especially, the fragmented QRS potential and symptoms were important in hypertrophic cardiomyopathy and Brugada syndrome, and could be applied to patients with ACHD. However, in ACHD cases, there was a large variety of diseases, and we found that it was difficult to predict using only conventional indicators. For scoring ACHD cases, it was found necessary to include quantification of invasive indicators.

Academic Significance and Societal Importance of the Research Achievements

心電図指標には様々なものがあるが、どの因子が予後を規定するかは不明である。今回の研究ではどの指標が重要で、何を注意して経過観察を行うべきかが明らかになった。特に基礎心疾患を有する症例について、心電図指標のみならず心室性期外収縮の形態によっても危険度を予測することが可能になった。これらの指標を注意深く観察することで若年者の突然死を予防することができれば社旗的意義は非常に高いといえる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results) Presentation (5 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] Efficacy of catheter ablation for paroxysmal atrial fibrillation in patients with atrial septal defect: a comparison with transcatheter closure alone2019

    • Author(s)
      Nakagawa K, Akagi T, Nagase S, Takaya Y, Kijima Y, Toh N, Watanabe A, Nishii N, Nakamura K, Morita H, Kusano K, Ito H
    • Journal Title

      Europace

      Volume: 21 Issue: 11 Pages: 1663-1669

    • DOI

      10.1093/europace/euz207

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognosis after lead extraction in patients with cardiac implantable electronic devices infection: Comparison of lead-related infective endocarditis with pocket infection in a Japanese single-center experience.2019

    • Author(s)
      Nishii N, Morimoto Y, Miyoshi A, Tsukuda S, Miyamoto M, Kawada S, Nakagawa K, Watanabe A, Nakamura K, Morita H, Morimatsu H, Kusano N, Kasahara S, Shoda M, Ito H
    • Journal Title

      J Arrhythm.

      Volume: 35 Issue: 4 Pages: 654-663

    • DOI

      10.1002/joa3.12164

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Low Critical Event Rate Despite a High Abnormal Event Rate in Patients with Cardiac Implantable Electric Devices Followed Up by Remote Monitoring.2019

    • Author(s)
      Morimoto Y, Nishii N, Tsukuda S, Kawada S, Miyamoto M, Miyoshi A, Nakagawa K, Watanabe A, Nakamura K, Morita H, Ito H.
    • Journal Title

      Intern Med.

      Volume: 58 Pages: 2333-2340

    • NAID

      130007690136

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency catheter ablation prior to percutaneous coronary intervention in patients with atrial fibrillation coexisting with stable coronary artery disease: a single-center pilot study.2019

    • Author(s)
      Kawada S, Watanabe A, Morimoto Y, Nakagawa K, Nishii N, Nakamura K, Morita H, Ito H.
    • Journal Title

      Heart Vessels.

      Volume: 34 Issue: 4 Pages: 632-640

    • DOI

      10.1007/s00380-018-1280-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of electrocardiographic risk markers for the initial and recurrent episodes of ventricular fibrillation in patients with Brugada syndrome.2018

    • Author(s)
      Morita H, Watanabe A, Kawada S, Miyamoto M, Morimoto Y, Nakagawa K, Nishii N, Nakamura K, Ito H.
    • Journal Title

      J Cardiovasc Electrophysiol

      Volume: 29 Issue: 1 Pages: 107-114

    • DOI

      10.1111/jce.13349

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of arrhythmic events is useful to detect lead failure earlier in patients followed by remote monitoring.2018

    • Author(s)
      Nishii N, Miyoshi A, Kubo M, Miyamoto M, Morimoto Y, Kawada S, Nakagawa K, Watanabe A, Nakamura K, Morita H, Ito H.
    • Journal Title

      J Cardiovasc Electrophysiol.

      Volume: 29 Issue: 3 Pages: 463-470

    • DOI

      10.1111/jce.13399

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recording of isolated very delayed potentials on the right ventricular epicardium in a patient with Brugada syndrome.2017

    • Author(s)
      Watanabe A, Morita H, Tsushima S, Nakagawa K, Nishii N, Ito H.
    • Journal Title

      HeartRhythm Case Rep

      Volume: 3 Issue: 7 Pages: 344-347

    • DOI

      10.1016/j.hrcr.2017.05.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution and Prognostic Significance of Fragmented QRS in Patients with Brugada Syndrome.2017

    • Author(s)
      Morita H, Watanabe A, Morimoto Y, Kawada S, Tachibana M, Nakagawa K, Nishii N, Ito H.
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 印刷中 Issue: 3

    • DOI

      10.1161/circep.116.004765

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Catheter Ablation of Left Ventricular Arrhythmias Using the Real-Time Three-Dimensional Anatomic Geometry from Ultrasound2019

    • Author(s)
      Atsuyuki Watanabe, Yuki Takenaka, Hironori Nishiyama, Saori Asada, Tomoo Kimura, Yoshimasa Morimoto, Masakazu Miyamoto, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Morita Hiroshi, Ito Hiroshi
    • Organizer
      第66回日本不整脈心電学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The Clinical Characteristics in Patients with Hypertrophic Cardiomyopathy Related Ventricular Arrhythmia2018

    • Author(s)
      Atsuyuki Watanabe, Saori Tsukuda, Masakazu Miyamoto, Yoshimasa Morimoto, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito
    • Organizer
      APHRS 2018 Taipei: The 11th APHRS Scientific Session
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The relationship with scar location and QRS morphology of ventricular tachycardia in patients with hypertrophic cardiomyopathy2018

    • Author(s)
      Watanabe A, Morita H, Kawada S, Miyamoto M, Morimoto Y, Nakagawa K, Nishii N, Nakamura K, Ito H.
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] The Significance of Detailed Endocardial and Epicardial Mapping with Ventricular Tachyarrhythmias in Patients with Brugada syndrome2017

    • Author(s)
      Watanabe A, Morita H, Kawada S, Miyamoto M, Morimoto Y, Nakagawa K, Nishii N, Nakamura K, Ito H.
    • Organizer
      Heart Rhythm Society (HRS) Scientific Sessions 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Refractory Repetitive Ventricular Tachycardia In Patients With Hypertrophic Cardiomyopathy2017

    • Author(s)
      Watanabe A, Morita H, Kawada S, Miyamoto M, Morimoto Y, Nakagawa K, Nishii N, Nakamura K, Ito H.
    • Organizer
      Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 循環器内科グリーンノート2018

    • Author(s)
      渡邊 敦之
    • Total Pages
      542
    • Publisher
      中外医学社
    • ISBN
      9784498134270
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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