| Project/Area Number |
17K09502
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木原 康樹 広島大学, 医系科学研究科(医), 教授 (40214853)
山本 秀也 安田女子大学, 薬学部, 教授 (70335678)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 心外膜下脂肪 / 冠動脈硬化症 / 分子イメージング / PET / 内臓脂肪 |
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| Outline of Final Research Achievements |
We reported that epicardial adipose tissue (EAT) obtained at cardiac surgeries had active pathological inflammation and increased expression of physiological active substance (cytokine), and that those characteristics were correlated with progression of coronary atherosclerosis. These suggest the importance of EAT assessment in diagnosis and treatment of coronary atherosclerosis.
On the one hand, we reported that a new PET tracer, 18F-sodium fluoride(NaF), contributed to detection of unstable coronary atherosclerosis and high-risk patients resulting in future coronary events. These suggest the usefulness of NaF PET as a next-generation imaging modality.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、心臓周囲の脂肪組織（心外膜下脂肪：EAT)における炎症などの現象と冠動脈硬化症との関連について新たな知見を明らかとした。EATの心臓病に関わるメカニズム解明を進め、臨床的なEAT評価法の確立にも貢献することが期待される。
また、新たな試薬を用いたPET検査が冠動脈硬化症の評価、リスク判定に有用であることを明らかとし、次世代の血管病画像診断の確立に貢献することが期待される。
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