| Project/Area Number |
17K09515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Sato Takamasa 福島県立医科大学, 医学部, 助教 (60566545)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生体インピーダンス法 / うっ血性心不全 / 体液貯留 / 慢性心不全 / 循環器 / 心不全 |
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| Outline of Final Research Achievements |
Using multi-frequency bioelectrical impedance analysis (BIA), we measured extracellular water (ECW) volume in 505 chronic heart failure (CHF) patients just before discharge. At the same time, We measured type B natriuretic peptide (BNP), physical examination and parameters derived from echocardiography. A weakly positive correlation was observed between measured/predicted (M/P) ratio of ECW and BNP or estimated systolic pulmonary artery pressure in CHF patients. Also, M/P ratio was an independent factor to predict adverse cardiac event (cardiac death and rehospitalization due to worsenig heart failure). Our study suggested that M/P ratio might be useful to treat CHF patients.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性心不全患者における生体インピーダンス法による体液量評価は従来の指標では評価できない、Hemodynamic congestionを評価できる可能性がある。また、M/P ratioをメルクマールにうっ血解除を図ることによって利尿剤の適正化を目指すことも可能であることが示唆され、今後の心不全診療の一助になる可能性が示唆される。
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