Molecular background of circadian rhythm of development of ventricuar arrhythmia in patients with Brugada syndrome

• Project/Area Number: 17K09524
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: International University of Health and Welfare (2018-2021); Keio University (2017)
• Principal Investigator: Yoshiyasu Aizawa 国際医療福祉大学, 医学部, 准教授 (20528145)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ブルガダ症候群 / 突然死 / 遺伝子解析 / 日内変動 / 臨床心臓学

Outline of Final Research Achievements

Brugada syndrome arrhythmias are known to occur during nighttime sleep, but the details of the arrhythmic arrhythmia mechanism are unclear. The purpose of this study was to comprehensively analyze the genomes of patients with Brugada syndrome with a next-generation sequencer, and to clarify the molecular biological background of circadian rhythms.
So far, 145 gene samples of Brugada syndrome patients have been collected. Panel or exsome analysis revealed rare variants in 12 SCN5A cases, 2 SCN3B cases, 1 SCN10A case, 1 GPD1L case, and 6 desmosome-related genes. The mutation identification rate was 15%.

Academic Significance and Societal Importance of the Research Achievements

若年性心臓突然死を来す循環器疾患のうち、代表的なブルガダ症候群において、申請者は臨床的に問題となる電気的ストームは日内・週内・季節変動することを初めて一連の患者で報告した。ブルガダ症候群の不整脈は夜間睡眠中に起きることが知られているが、不整脈の概日リズムのメカニズムの詳細は未解明である。ブルガダ症候群患者のゲノムを次世代シークエンサーで網羅的に解析し、ひいては概日リズムの分子生物学的背景を解 明することを目的として研究を行い、背景にある遺伝子異常を一部の症例で明らかにした。

Research Products

• [Journal Article] Incidence and Implications of J waves Observed During Coronary Angiography. (2022)
  • Author(s): Sakaguchi Y, Sato T, Sato A, Fuse K, Aizawa Y, Okabe M, Aizawa Y.
  • Journal Title: Am J Cardiol. Volume: 163 Pages: 32-37
  • DOI: 10.1016/j.amjcard.2021.09.035
  • Peer Reviewed
• [Journal Article] Exercise-induced Atrioventricular Block (2021)
  • Author(s): Aizawa Yoshiyasu、Kawamura Akio
  • Journal Title: Internal Medicine Volume: 60 Issue: 6 Pages: 827-828
  • DOI: 10.2169/internalmedicine.6150-20
  • NAID: 130007998518
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-03-15
• [Journal Article] Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside. (2021)
  • Author(s): Yamakawa H, Kato TS, Noh JY, Yuasa S, Kawamura A, Fukuda K, Aizawa Y.
  • Journal Title: Front Physiol. Volume: 12 Pages: 606931-606931
  • DOI: 10.3389/fphys.2021.606931
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Features of Probands With Early Repolarization and Brugada Syndromes Carrying SCN5A Pathogenic Variants. (2021)
  • Author(s): Zhang ZH, Barajas-Martinez H, Xia H, Li B, Capra JA, Clatot J, Chen GX, Chen X, Yang B, Jiang H, Tse G, Aizawa Y, Gollob MH, Scheinman M, Antzelevitch C, Hu D.
  • Journal Title: J Am Coll Cardiol. Volume: 78(16) Issue: 16 Pages: 1603-1617
  • DOI: 10.1016/j.jacc.2021.08.024
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Successful Leadless Pacemaker Implantation in an Elderly Patient With Dextrocardia and Situs Inversus. (2021)
  • Author(s): Aizawa Y, Ichiki T, Yoshizawa A, Monma Y, Nakayama T, Kato TS, Inami S, Fujimoto Y, Kawamura A.
  • Journal Title: Cureus. Volume: 13(9)
  • DOI: 10.7759/cureus.17858
  • Peer Reviewed
• [Journal Article] Functionally validated SCN5A variants allow interpretation of pathogenicity and prediction of lethal events in Brugada syndrome. (2021)
  • Author(s): Ishikawa T, Kimoto H, Mishima H, Yamagata K, Ogata S, Aizawa Y, Hayashi K, Morita H, Nakajima T, Nakano Y, Nagase S, Murakoshi N, Kowase S, Ohkubo K, Aiba T, Morimoto S, Ohno S, Kamakura S, Nogami A, Takagi M, Karakachoff M, Dina C, Schott JJ, Yoshiura KI, Horie M, Shimizu W, Nishimura K, Kusano K, Makita N.
  • Journal Title: Eur Heart J. Volume: 42(29) Issue: 29 Pages: 2854-2863
  • DOI: 10.1093/eurheartj/ehab254
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Electrocardiographic manifestations in a large right-sided pneumothorax (2021)
  • Author(s): Yamamoto Hiroyuki、Satomi Kazuhiro、Aizawa Yoshiyasu
  • Journal Title: BMC Pulmonary Medicine Volume: 21 Issue: 1 Pages: 101-101
  • DOI: 10.1186/s12890-021-01470-1
• [Journal Article] Electrical Isolation of the Marshall Bundle by Radiofrequency Catheter Ablation (2020)
  • Author(s): Kashimura Shin、Fujisawa Taishi、Nakajima Kazuaki、Kunitomi Akira、Katsumata Yoshinori、Nishiyama Takahiko、Kimura Takehiro、Nishiyama Nobuhiro、Aizawa Yoshiyasu、Fukuda Keiichi、Takatsuki Seiji
  • Journal Title: JACC: Clinical Electrophysiology Volume: 6 Issue: 13 Pages: 1647-1657
  • DOI: 10.1016/j.jacep.2020.06.025
• [Journal Article] Symptom burden and treatment perception in patients with atrial fibrillation, with and without a family history of atrial fibrillation (2020)
  • Author(s): Fujisawa Taishi、Kimura Takehiro、Kohsaka Shun、Ikemura Nobuhiro、Katsumata Yoshinori、Miyama Hiroshi、Nakajima Kazuaki、Nishiyama Takahiko、Aizawa Yoshiyasu、Kanki Hideaki、Nagami Keiichi、Fukuda Keiichi、Takatsuki Seiji
  • Journal Title: Heart and Vessels Volume: 36 Issue: 2 Pages: 267-276
  • DOI: 10.1007/s00380-020-01687-w
  • Peer Reviewed
• [Journal Article] Discrepancy in recognition of symptom burden among patients with atrial fibrillation (2020)
  • Author(s): Katsumata Yoshinori、Kimura Takehiro、Kohsaka Shun、Ikemura Nobuhiro、Ueda Ikuko、Fujisawa Taishi、Nakajima Kazuaki、Nishiyama Takahiko、Aizawa Yoshiyasu、Oki Takahiro、Suzuki Masahiro、Heidenreich Paul A、Fukuda Keiichi、Takatsuki Seiji
  • Journal Title: American Heart Journal Volume: 226 Pages: 240-249
  • DOI: 10.1016/j.ahj.2020.03.024
  • Peer Reviewed
• [Journal Article] Mexiletine shortens the QT interval in a pedigree of KCNH2 related long QT syndrome. (2020)
  • Author(s): Fujisawa T, Aizawa Y, Katsumata Y, Kimura K, Hashimoto K, Yamashita T, Miyama H, Kimura T, Kosaki K, Takatsuki S, Shimizu W, Fukuda K.
  • Journal Title: J Arrhythm. Volume: 36 Issue: 1 Pages: 193-196
  • DOI: 10.1002/joa3.12300
  • Peer Reviewed / Open Access
• [Journal Article] Early repolarization in athletes. (2019)
  • Author(s): Aizawa Y, Kawamura A.
  • Journal Title: J Arrhythm. Volume: 35 Issue: 6 Pages: 868-869
  • DOI: 10.1002/joa3.12247
  • Peer Reviewed / Open Access
• [Journal Article] A high BNP level predicts an improvement in exercise tolerance after a successful catheter ablation of persistent atrial fibrillation. (2019)
  • Author(s): Katsumata Y, Tamura Y, Kimura T, Kohsaka S, Sadahiro T, Nishiyama T, Aizawa Y, Azuma K, Fukuda K, Takatsuki S.
  • Journal Title: J Cardiovasc Electrophysiol. Volume: 30 Issue: 11 Pages: 2283-2290
  • DOI: 10.1111/jce.14149
  • Peer Reviewed / Open Access
• [Journal Article] The Durability of Atrial Fibrillation Ablation Using an Oesophageal Temperature Cut-Off of 38°C. (2019)
  • Author(s): Kimura T, Nishiyama N, Negishi M, Nishiyama A, Takazawa T, Fujisawa T, Nakajima K, Kashimura S, Kunitomi A, Katsumata Y, Nishiyama T, Aizawa Y, Fukuda K, Takatsuki S.
  • Journal Title: Heart Lung Circ. Volume: 28 Issue: 7 Pages: 1050-1058
  • DOI: 10.1016/j.hlc.2018.05.197
  • Peer Reviewed
• [Journal Article] Assessment of Sex Differences in the Initial Symptom Burden, Applied Treatment Strategy, and Quality of Life in Japanese Patients With Atrial Fibrillation. (2019)
  • Author(s): Ikemura N, Kohsaka S, Kimura T, Ueda I, Katsumata Y, Nishiyama T, Aizawa Y, Tanimoto K, Momiyama Y, Akaishi M, Mitamura H, Fukuda K, Spertus JA, Takatsuki S.
  • Journal Title: JAMA Netw Open. Volume: 2 Issue: 3 Pages: e191145-e191145
  • DOI: 10.1001/jamanetworkopen.2019.1145
  • Peer Reviewed / Open Access
• [Journal Article] Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients (2019)
  • Author(s): Shimizu Wataru、Makimoto Hisaki、Yamagata Kenichiro、Kamakura Tsukasa、Wada Mitsuru、Miyamoto Koji、Inoue-Yamada Yuko、Okamura Hideo、Ishibashi Kohei、Noda Takashi、Nagase Satoshi、Miyazaki Aya、Sakaguchi Heima、Shiraishi Isao、Makiyama Takeru、Ohno Seiko、Itoh Hideki、et al
  • Journal Title: JAMA Cardiology Volume: in press Issue: 3 Pages: 246-254
  • DOI: 10.1001/jamacardio.2018.4925
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Conduction Delay-Induced J-Wave Augmentation in Patients With Coronary Heart Disease. (2019)
  • Author(s): Nakayama M, Satomi K, Yuhara M, Uchiyama T, Aizawa Y, Aizawa Y.
  • Journal Title: Am J Cardiol. Volume: 123 Issue: 8 Pages: 1262-1266
  • DOI: 10.1016/j.amjcard.2019.01.015
  • Peer Reviewed
• [Journal Article] A Homozygous CASQ2 Mutation in a Japanese Patient with Catecholaminergic Polymorphic Ventricular Tachycardia. (2019)
  • Author(s): Fujisawa T, Aizawa Y, Katsumata Y, Udo A, Ito S, Hatakeyama K, Hirose M, Miyama H, Nakajima K, Nishiyama T, Kimura T, Nitta M, Misumi K, Takatsuki S, Kosaki K, Fukuda K.
  • Journal Title: Case Rep Genet. Volume: Jan 8 Pages: 9056596-9056596
  • DOI: 10.1155/2019/9056596
  • Peer Reviewed / Open Access
• [Journal Article] Incidence, Clinical Characteristics, and Long-term Outcome of the Dilated Phase of Hypertrophic Cardiomyopathy (2018)
  • Author(s): Aizawa Y, Tanimoto Y, Hirata Y, Fujisawa T, Fukuoka R, Nakajima K, Katsumata Y, Nishiyama T, Kimura T, Yuasa S, Kohno T, Kohsaka S, Murata M, Maekawa Y, Furukawa Y, Takatsuki S, Fukuda K.
  • Journal Title: The Keio Journal of Medicine Volume: 68 Issue: 4 Pages: 87-94
  • DOI: 10.2302/kjm.2018-0004-OA
  • NAID: 130007772353
  • ISSN: 0022-9717, 1880-1293
  • Peer Reviewed / Open Access
• [Journal Article] Sex-Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome. (2018)
  • Author(s): Aizawa Y, Fujisawa T, Katsumata Y, Kohsaka S, Kunitomi A, Ohno S, Sonoda K, Hayashi H, Hojo R, Fukamizu S, Nagase S, Ito S, Nakajima K, Nishiyama T, Kimura T, Kurita Y, Furukawa Y, Takatsuki S, Ogawa S, Nakazato Y, Sumiyoshi M, Kosaki K, Horie M, Fukuda K.
  • Journal Title: J Am Heart Assoc. Volume: 7(18) Issue: 18
  • DOI: 10.1161/jaha.118.009387
  • Peer Reviewed / Open Access
• [Journal Article] A tale of two sisters with hypertrophic cardiomyopathy and recurrent embolism: When is the optimal timing of the intervention for left atrial appendage? (2018)
  • Author(s): Kimura M, Kohno T, Makino S, Okuda S, Nawata K, Yanagisawa R, Kojima H, Nishiyama T, Aizawa Y, Yuasa S, Murata M, Maekawa Y, Okamoto K, Shimizu H, Fukuda K.
  • Journal Title: Int J Cardiol. Volume: 270 Pages: 187-187
  • DOI: 10.1016/j.ijcard.2018.06.049
  • Peer Reviewed / Open Access
• [Journal Article] Dynamicity of hypothermia-induced J waves and the mechanism involved. (2018)
  • Author(s): Aizawa Y, Hosaka Y, Oda H, Fuse K, Okabe M, Kaneko Y, Takahashi N, Zaizen H, Aizawa Y, Fukuda K.
  • Journal Title: Heart Rhythm. Volume: 19 Issue: 1 Pages: 74-80
  • DOI: 10.1016/j.hrthm.2018.07.024
• [Journal Article] Prevalence and clinical characteristics of obstructive- and central-dominant sleep apnea in candidates of catheter ablation for atrial fibrillation in Japan (2018)
  • Author(s): Kohno Takashi、Kimura Takehiro、Fukunaga Koichi、Yamasawa Wakako、Fujisawa Taishi、Fukuoka Ryoma、Nakajima Kazuaki、Kashimura Shin、Kunitomi Akira、Katsumata Yoshinori、Nishiyama Takahiko、Nishiyama Nobuhiro、Aizawa Yoshiyasu、Fukuda Keiichi、Takatsuki Seiji
  • Journal Title: International Journal of Cardiology Volume: 260 Pages: 99-102
  • DOI: 10.1016/j.ijcard.2018.01.103
  • Peer Reviewed
• [Journal Article] Real‐Time Analysis of the Heart Rate Variability During Incremental Exercise for the Detection of the Ventilatory Threshold (2018)
  • Author(s): Shiraishi Yasuyuki、Katsumata Yoshinori、Sadahiro Taketaro、Azuma Koichiro、Akita Keitaro、Isobe Sarasa、Yashima Fumiaki、Miyamoto Kazutaka、Nishiyama Takahiko、Tamura Yuichi、Kimura Takehiro、Nishiyama Nobuhiro、Aizawa Yoshiyasu、Fukuda Keiichi、Takatsuki Seiji
  • Journal Title: Journal of the American Heart Association Volume: 7 Issue: 1
  • DOI: 10.1161/jaha.117.006612
  • Peer Reviewed / Open Access
• [Journal Article] Real-world monitoring of direct oral anticoagulants in clinic and hospitalization settings (2017)
  • Author(s): Takatsuki Seiji、Kimura Takehiro、Sugimoto Kazutaka、Misaki Sadaya、Nakajima Kazuaki、Kashimura Shin、Kunitomi Akira、Katsumata Yoshinori、Nishiyama Takahiko、Nishiyama Nobuhiro、Aizawa Yoshiyasu、Fukuda Keiichi
  • Journal Title: SAGE Open Medicine Volume: 5 Pages: 1-9
  • DOI: 10.1177/2050312117734773
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary Artery Denervation by Determining Targeted Ablation Sites for Treatment of Pulmonary Arterial Hypertension (2017)
  • Author(s): Fujisawa Taishi、Kataoka Masaharu、Kawakami Takashi、Isobe Sarasa、Nakajima Kazuaki、Kunitomi Akira、Kashimura Shin、Katsumata Yoshinori、Nishiyama Takahiko、Kimura Takehiro、Nishiyama Nobuhiro、Aizawa Yoshiyasu、Murata Mitsushige、Fukuda Keiichi、Takatsuki Seiji
  • Journal Title: Circulation: Cardiovascular Interventions Volume: 10 Issue: 10
  • DOI: 10.1161/circinterventions.117.005812
  • Peer Reviewed
• [Journal Article] Mitral isthmus ablation using a circular mapping catheter positioned in the left atrial appendage as a reference for conduction block (2017)
  • Author(s): Nishiyama Takahiko、Kimura Takehiro、Fujisawa Taishi、Nakajima Kazuaki、Kunitomi Akira、Kashimura Shin、Katsumata Yoshinori、Nishiyama Nobuhiro、Aizawa Yoshiyasu、Fukuda Keiichi、Takatsuki Seiji
  • Journal Title: Oncotarget Volume: 8 Issue: 32 Pages: 52724-52734
  • DOI: 10.18632/oncotarget.17092
  • Peer Reviewed / Open Access
• [Journal Article] A subtype of idiopathic ventricular fibrillation and its relevance to catheter ablation and genetic variants (2017)
  • Author(s): Nishiyama Takahiko、Aizawa Yoshiyasu、Ito Shogo、Katsumata Yoshinori、Kimura Takehiro、Takatsuki Seiji
  • Journal Title: HeartRhythm Case Rep Volume: 3 Issue: 5 Pages: 277-281
  • DOI: 10.1016/j.hrcr.2017.03.004
  • Peer Reviewed / Open Access
• [Journal Article] Tachycardia-Induced J-Wave Changes in Patients With and Without Idiopathic Ventricular Fibrillation (2017)
  • Author(s): Aizawa Yoshiyasu、Takatsuki Seiji、Nishiyama Takahiko、Kimura Takehiro、Kohsaka Shun、Kaneko Yoshiaki、Inden Yasuya、Takahashi Naohiko、Nagase Satoshi、Aizawa Yoshifusa、Fukuda Keichi
  • Journal Title: Circulation: Arrhythmia and Electrophysiology Volume: 10 Issue: 7
  • DOI: 10.1161/circep.117.005214
  • Peer Reviewed
• [Journal Article] Effect of Compliance to Updated AHA/ACC Performance and Quality Measures Among Patients With Atrial Fibrillation on Outcome (from Japanese Multicenter Registry) (2017)
  • Author(s): Inohara Taku、Kimura Takehiro、Ueda Ikuko、Ikemura Nobuhiro、Tanimoto Kojiro、Nishiyama Nobuhiro、Aizawa Yoshiyasu、Nishiyama Takahiko、Katsumata Yoshinori、Fukuda Keiichi、Takatsuki Seiji、Kohsaka Shun
  • Journal Title: The American Journal of Cardiology Volume: 120 Issue: 4 Pages: 595-600
  • DOI: 10.1016/j.amjcard.2017.05.029
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vein of Marshall partially isolated with radiofrequency ablation from the endocardium (2017)
  • Author(s): Shin Kashimura, Takahiko Nishiyama, Takehiro Kimura, Nobuhiro Nishiyama, Yoshiyasu Aizawa, Seiji Takatsuki
  • Journal Title: Heart Rhythm Case Reports Volume: 3 Issue: 2 Pages: 120-123
  • DOI: 10.1016/j.hrcr.2016.08.008
  • Peer Reviewed / Open Access
• [Journal Article] “J waves” induced after short coupling intervals: a manifestations of latent depolarization abnormality? (2017)
  • Author(s): Aizawa Yoshifusa、Nakayama Masafumi、Sato Masahito、Okabe Masaaki、Aizawa Yoshiyasu、Takatsuki Seiji、Fukuda Keiichi
  • Journal Title: EP Europace Volume: 印刷中 Issue: FI1 Pages: f86-f92
  • DOI: 10.1093/europace/eux062
  • Peer Reviewed
• [Journal Article] Discrimination Between QRS and T Waves Using a Right Parasternal Lead for S-ICD in a Patient with a Single Ventricle (2017)
  • Author(s): Nishiyama T, Kimura T, Nishiyama N, Aizawa Y, Fukuda K, Takatsuki S
  • Journal Title: Pacing Clinical Electrophysiolgy Volume: 印刷中 Issue: 7 Pages: 904-907
  • DOI: 10.1111/pace.13046
  • Peer Reviewed
• [Journal Article] A Novel SCN5A Mutation Found in a Familial Case of Long QT Syndrome Complicated by Severe Left Ventricular Dysfunction (2017)
  • Author(s): Kimura Mai、Kohno Takashi、Aizawa Yoshiyasu、Inohara Taku、Shiraishi Yasuyuki、Katsumata Yoshinori、Egashira Toru、Fukushima Hiroyuki、Kosaki Kenjiro、Fukuda Keiichi
  • Journal Title: Can J Cardiol Volume: 33 Issue: 4 Pages: 554.e5-554.e7
  • DOI: 10.1016/j.cjca.2016.10.010
  • Peer Reviewed
• [Presentation] J波症候群の臨床と心電学的特徴 (2020)
  • Author(s): 相澤義泰
  • Organizer: 日本不整脈心電学会夏季EP Web講演会
  • Invited
• [Presentation] Characteristics of J save syndrome (2020)
  • Author(s): Yoshiyasu Aizawa
  • Organizer: 第84回日本循環器学会学術集会
  • Int'l Joint Research / Invited
• [Presentation] An update on approach to therapy for J-wave syndrome. (2019)
  • Author(s): Yoshiyasu Aizawa
  • Organizer: The 12th annual Asia Pacific Heart Rhythm Society Scientific Session
  • Int'l Joint Research / Invited
• [Presentation] Unmasking Brugada syndrome behind complete right bundle branch block by ventricular pacing. (2017)
  • Author(s): 52.Yoshiyasu Aizawa, Seiji Takatsuki, Takashi Komatsu, Kazuaki Nakajima, Shogo Ito, Shin Kashimura, Akira Kunitomi, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoko Tanimoto, Yoshifusa Aizawa, Keiichi Fukuda.
  • Organizer: 第63回日本不整脈心電学会学術大会
  • Int'l Joint Research
• [Presentation] Sex Dependent Risk of Sudden Death or Sick Sinus Syndrome in a Family with Brugada Syndrome. (2017)
  • Author(s): Yoshiyasu Aizawa, Taishi Fujisawa, Yoshinori Katsumata, Seiko Ohno, Keiko Sonoda, Hidemori Hayashi, Rintaro Hojo, Seiji Fukamizu, Takehiro Kimura, Nobuhiro Nishiyama, Yasuo Kurita, Seiji Takatsuki, Satoshi Ogwa, Kenjiro Kosaki, Yuji Nakazato, Minoru Horie, Keiichi Fukuda.
  • Organizer: APHRS2017/JHRS2017
  • Int'l Joint Research
• [Book] ハートナーシング【このまま患者さんに説明できる!ややこしくないペースメーカー・ICD・CRT】新人ナースも知っておきたい 各デバイスの適切作動・不適切作動(解説/特集) (2019)
  • Author(s): 相澤義泰
  • Total Pages: 16
  • Publisher: メディカ出版
• [Book] 【知っておきたい遺伝性不整脈】 Brugada症候群．臨床検査 (2018)
  • Author(s): 相澤 義泰．
  • Publisher: 医学書院
• [Book] 慶應循環器内科カンファレンス(第69回) 高齢の徐脈性心房細動・安全房室ブロックに対してリードレスペースメーカ植込みを行った1例．月刊レジデント (2018)
  • Author(s): 相澤 義泰．
  • Publisher: 医学出版
• [Book] EMERGENCY CARE (2018)
  • Author(s): 相澤義泰
  • Total Pages: 9
  • Publisher: メディカ出版