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Exploration of nodal cells in pericardial adipose tissue

Research Project

Project/Area Number 17K09530
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionShowa University

Principal Investigator

Indole Shin  昭和大学, 歯学部, 教授 (00201335)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsatrioventricular node / nodal extension / 刺激伝導系 / dual AV node physiology / ganglionated plexi / 解剖学 / 不整脈
Outline of Final Research Achievements

For reviewing anatomical distribution of the nodal tissue on the septal parts of atrioventricular (AV) junction especially around the peak of Koch triangle, serial tissue sections in this area have been examined. Serial sections were prepared from 20 human hearts (8 female, 23 to 89 years of age) without conspicuous arrhythmia related to AV node, and every 10th section was stained with elastica van Gieson and observed under microscope. Within 20 human hearts without conspicuous atrial arrhythmias, left superior extension (LSE) 12 cases, right superior extension (RSE) 14 cases, left inferior extension (LIE) 14 cases, right inferior extension (RIE) 18 cases, are observed. On both sides of right fibrous trigone, right or left superior nodal extensions of the AV node appeared as normal tissue variation.

Academic Significance and Societal Importance of the Research Achievements

この研究では房室結節組織の広がりが頻拍症の成因にさまざまな程度で関与しそのバリエーションが形態学的に説明可能であることを示した。結節組織の広がりが明らかになったことで、この組織に分布する自律神経の関与も解明された。房室結節回帰性頻拍症の成因のうち、房室伝導時間の違いは解剖学的な結節組織の長さの差で説明可能であったが、不応期の違いについては不明であった。今回の検討で速伝導路に相応するcompact node部は中隔域の神経支配を受けるが、遅伝導路である上下の伸展組織は自由壁の神経支配であり、その神経支配の差異がこの不整脈の発症にかかわることが示唆され、新たな治療法に結び付くと期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2021 2019 2018 2017

All Journal Article (1 results) (of which Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] 特別寄稿、房室結節の構造と機能―臨床的意義と 40 年間の研究の歩み―2021

    • Author(s)
      井上 紳
    • Journal Title

      昭和学士会雑誌

      Volume: 81巻2号予定 Pages: 1-11

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Presentation] 心房筋および房室結節の組織多様性について―心房内・心房間・房室伝導に関する考察2019

    • Author(s)
      井上 紳
    • Organizer
      第41回心筋生検研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Superior atrioventricular nodal extension as potential substrates for atrioventricular nodal reentrant tachycardia with superior slow pathway: Anatomical study in human hearts2018

    • Author(s)
      Shin Inoue, Taka-aki Matsuyama, Masafumi Takimoto
    • Organizer
      ESC CONGRESS 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The outline of the Tawara’s node-Recent aspect from morphological and functional approaches-2017

    • Author(s)
      Shin Inoue, Genyo Ogawa, Taka-aki Matsuyama
    • Organizer
      63rd annual scientific meeting of Japanese Heart Rhythm Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] Catheter Ablation2018

    • Author(s)
      Kenzo Hirao Editor
    • Total Pages
      390
    • Publisher
      Springer
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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