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Proposal of exercise therapy for heart disease patients using wearable activity and heart rate monitor and investigation of prognosis

Research Project

Project/Area Number 17K09533
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionFujita Health University

Principal Investigator

Watanabe Eiichi  藤田医科大学, 医学部, 教授 (80343656)

Co-Investigator(Kenkyū-buntansha) 吉岡 公一郎  東海大学, 医学部, 教授 (30246087)
清野 健  大阪大学, 基礎工学研究科, 教授 (40434071)
原田 将英  藤田医科大学, 医学部, 准教授 (70514800)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords運動耐容能 / 予後 / 循環器疾患 / フレイル / 心疾患 / サルコペニア / 心拍 / 体動 / 加速度 / ウェアラブル / 身体的フレイル / 心拍応答特性 / リハビリテーション
Outline of Final Research Achievements

In healthy people, the heart rate rapidly increases in response to physical activity, but in heart disease patients, the ability to control heart rate with exercise decreases due to autonomic nervous dysfunction and frailty. Although this "chronotropic response" is associated with QOL and prognosis, a simple measurement method has not been developed. In this study, after performing frailty questionnaire for heart disease patients, wearable activity / heart rate monitor was attached to the chest, and the ratio of acceleration deviation (exercise / work intensity) to heart rate was defined as the chronotropic response. Analysis showed that the heart disease patients had lower chronotropic response than those of healthy subjects, and a negative correlation with the frailty score was observed. In conclusion, our data suggested that the chronotropic response could be easily obtained in daily life and that it could be a new flail evaluation method.

Academic Significance and Societal Importance of the Research Achievements

高齢化に伴い心臓病患者が増加しているが、これは社会的にも医療経済的にも大きな問題である。運動療法は心臓病の予防と病態の進行抑制に有効であるが、個々の心拍応答特性に見合った運動処方を行うには高度な検査が必要である。本研究ではウェアラブルモニターを用いて、日常生活下の心拍応答特性算出アルゴリズムを開発した。心臓病患者の心拍応答特性は約7000人の健常人より求められた基準範囲より低下しており、さらに、心拍応答特性はフレイル評価値と負の相関が認められた。本研究によりウェアラブルモニターを貼付することでフレイル評価と心拍応答特性の算出ができ、これに基づく運動処方が行える可能性がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (30 results)

All 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (19 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 19 results,  Open Access: 11 results) Presentation (8 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Int'l Joint Research] University of Pisa/DEIB, Politecnico di Milano(Italy)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Ecole Normale Superieure de Lyon(France)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Cardiac Arrest Associated with Both an Anomalous Left Coronary Artery and KCNE1 Polymorphism2019

    • Author(s)
      Kawai Hideki、Watanabe Eiichi、Ohno Seiko、Horie Minoru、Ozaki Yukio
    • Journal Title

      International Heart Journal

      Volume: 60 Issue: 4 Pages: 1003-1005

    • DOI

      10.1536/ihj.18-581

    • NAID

      130007684099

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-07-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Decision Tree-Based Survival Analysis of Patients with a History of Inappropriate Implantable Cardioverter-Defibrillator Therapy2019

    • Author(s)
      Yamamoto Masaru、Okajima Katsunori、Shimane Akira、Ozawa Tomoya、Morishima Itsuro、Asai Toru、Takagi Masahiko、Kasai Atsunobu、Fujii Eitaro、Kiyono Ken、Watanabe Eiichi、Ozaki Yukio
    • Journal Title

      International Heart Journal

      Volume: 60 Issue: 2 Pages: 318-326

    • DOI

      10.1536/ihj.18-288

    • NAID

      130007617732

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-03-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The presence of late potentials after percutaneous coronary intervention for the treatment of acute coronary syndrome as a predictor for future significant cardiac events resulting in re-hospitalization2019

    • Author(s)
      Amino Mari、Yoshioka Koichiro、Ichikawa Tomohide、Watanabe Eiichi、Kiyono Ken、Nakamura Mari、Sakama Susumu、Ayabe Kengo、Fujii Toshiharu、Hashida Tadashi、Kanda Shigetaka、Tanabe Teruhisa、Ikari Yuji
    • Journal Title

      Journal of Electrocardiology

      Volume: 53 Pages: 71-78

    • DOI

      10.1016/j.jelectrocard.2019.01.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wavelet <inline-formula> <tex-math notation="LaTeX">$p$</tex-math> </inline-formula>-Leader Non Gaussian Multiscale Expansions for Heart Rate Variability Analysis in Congestive Heart Failure Patients2019

    • Author(s)
      Wendt Herwig、Abry Patrice、Kiyono Ken、Hayano Junichiro、Watanabe Eiichi、Yamamoto Yoshiharu
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 66 Issue: 1 Pages: 80-88

    • DOI

      10.1109/tbme.2018.2825500

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of serum albumin levels on supratherapeutic PT-INR control and bleeding risk in atrial fibrillation patients on warfarin: A prospective cohort study.2019

    • Author(s)
      Kawai M, Harada M, Motoike Y, Koshikawa M, Ichikawa T, Watanabe E, Ozaki Y.
    • Journal Title

      Int J Cardiol Heart Vasc.

      Volume: 22 Pages: 111-116

    • DOI

      10.1016/j.ijcha.2019.01.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical experience of idarucizumab use in cases of cardiac tamponade under uninterrupted anticoagulation of dabigatran during catheter ablation of atrial fibrillation.2019

    • Author(s)
      Okishige K, amauchi Y, Hanaki Y, Inoue K, Tanaka N, Yamaji H, Murakami T, Manita M, Tabata K, Ooie T, Tatsukawa Y, Sakai H, Yamaki M, Murakami M, Takada T, Osaka Y, Ono Y, Handa K, Sugiyama K, Yoshizawa T, Fukaya H, Tashiro H, Takase S, Harada M, Watanabe E, Yamane T, Yamashita S, Aonuma K,
    • Journal Title

      J Thromb Thrombolysis

      Volume: 47 Issue: 4 Pages: 487-494

    • DOI

      10.1007/s11239-019-01835-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal Variability in The Implantations of Cardiovascular Electronic Devices2019

    • Author(s)
      Watanabe Eiichi、Kiyono Ken、Harada Masahide、Ozaki Yukio
    • Journal Title

      Cardiology and Cardiovascular Medicine

      Volume: 03 Issue: 04 Pages: 131-139

    • DOI

      10.26502/fccm.92920060

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Left Atrial Appendage Thrombus Prior to Atrial Fibrillation Ablation in the Era of Direct Oral Anticoagulants2018

    • Author(s)
      Harada Masahide、Koshikawa Masayuki、Motoike Yuji、Ichikawa Tomohide、Sugimoto Kunihiko、Watanabe Eiichi、Ozaki Yukio
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 11 Pages: 2715-2721

    • DOI

      10.1253/circj.CJ-18-0398

    • NAID

      40021697183

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2018-10-25
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrocadiographic Scoring Helps Predict Left Ventricular Wall Motion Abnormality Commonly Observed after Subarachnoid Hemorrhage2018

    • Author(s)
      Sugimoto Keiko、Yamada Akira、Inamasu Joji、Hirose Yuichi、Takada Kayoko、Sugimoto Kunihiko、Tanaka Risako、Watanabe Eiichi、Ozaki Yukio
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 27 Issue: 11 Pages: 3148-3154

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.07.008

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predicting acute kidney injury using urinary liver-type fatty-acid binding protein and serum N-terminal pro-B-type natriuretic peptide levels in patients treated at medical cardiac intensive care units.2018

    • Author(s)
      Naruse H, Ishii J, Takahashi H, et al.
    • Journal Title

      Critical Care

      Volume: 22 Issue: 1 Pages: 197-197

    • DOI

      10.1186/s13054-018-2120-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thromboembolisms in atrial fibrillation and heart failure patients with a preserved ejection fraction (HFpEF) compared to those with a reduced ejection fraction (HFrEF)2018

    • Author(s)
      Sobue Yoshihiro、Watanabe Eiichi、Lip Gregory Y. H.、Koshikawa Masayuki、Ichikawa Tomohide、Kawai Mayumi、Harada Masahide、Inamasu Joji、Ozaki Yukio
    • Journal Title

      Heart and Vessels

      Volume: 33 Issue: 4 Pages: 403-412

    • DOI

      10.1007/s00380-017-1073-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Analysis of variability of R-R intervals for the diagnosis of atrial fibrillation: A new algorithm2018

    • Author(s)
      Matsui Taishi、Shinozaki Ryo、Watanabe Eiichi、Aizawa Yoshifusa
    • Journal Title

      Journal of Electrocardiology

      Volume: 51 Issue: 3 Pages: 382-385

    • DOI

      10.1016/j.jelectrocard.2018.03.007

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Scattering Transform of Heart Rate Variability for the Prediction of Ischemic Stroke in Patients with Atrial Fibrillation2018

    • Author(s)
      Abry Patrice、Wendt Herwig、Kiyono Ken、Yamamoto Yoshiharu、Watanabe Eiichi、Hayano Junichiro、Leonarduzzi Roberto
    • Journal Title

      Methods of Information in Medicine

      Volume: 57 Issue: 03 Pages: 141-145

    • DOI

      10.3414/me17-02-0006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prognostic Value of Combination of Plasma D-Dimer Concentration and Estimated Glomerular Filtration Rate in Predicting Long-Term Mortality of Patients With Stable Coronary Artery Disease2017

    • Author(s)
      Naruse H, Ishii J, Takahashi H, Kitagawa F, Okuyama R, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Matsui S, Hayashi M, Sarai M, Watanabe E, Izawa H, Ozaki Y.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 10 Pages: 1506-1513

    • DOI

      10.1253/circj.CJ-16-1272

    • NAID

      130006099870

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of eicosapentaenoic acid and pitavastatin on electrophysiology and anticoagulant gene expression in mice with rapid atrial pacing2017

    • Author(s)
      Tong Maoqing、Wang Jiewen、Ji Yunxin、Chen Xiaomin、Wang Jieru、Wang Shuangshuang、Ruan Liemin、Cui Hanbin、Zhou Ying、Zhang Qingyu、Watanabe Eiichi
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 14 Issue: 3 Pages: 2310-2316

    • DOI

      10.3892/etm.2017.4741

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between Multiscale Entropy Characteristics of Heart Rate Variability and Ischemic Stroke Risk in Patients with Permanent Atrial Fibrillation2017

    • Author(s)
      Matsuoka Ryo、Yoshino Kohzoh、Watanabe Eiichi、Kiyono Ken
    • Journal Title

      Entropy

      Volume: 19 Issue: 12 Pages: 672-672

    • DOI

      10.3390/e19120672

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Driving restrictions in patients with implantable cardioverter defibrillators and pacemakers2017

    • Author(s)
      Watanabe Eiichi、Abe Haruhiko、Watanabe Shigeyuki
    • Journal Title

      Journal of Arrhythmia

      Volume: 33 Issue: 6 Pages: 594-601

    • DOI

      10.1016/j.joa.2017.02.003

    • NAID

      120007134614

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blunted cyclic variation of heart rate predicts mortality risk in post-myocardial infarction, end-stage renal disease, and chronic heart failure patients2017

    • Author(s)
      Hayano Junichiro、Yasuma Fumihiko、Watanabe Eiichi、Carney Robert M.、Stein Phyllis K.、Blumenthal James A.、Arsenos Petros、Gatzoulis Konstantinos A.、Takahashi Hiroshi、Ishii Hideki、Kiyono Ken、Yamamoto Yoshiharu、Yoshida Yutaka、Yuda Emi、Kodama Itsuo
    • Journal Title

      Europace

      Volume: 19 Pages: 1392-1400

    • DOI

      10.1093/europace/euw222

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inappropriate implantable cardioverter defibrillator shocks?incidence, effect, and implications for driver licensing2017

    • Author(s)
      Watanabe E、Okajima K、Shimane A、Ozawa T、Manaka T、Morishima I、Asai T、Takagi M、Honda T、Kasai A、Fujii E、Yamashiro K、Kohno R、Abe H、Noda T、Kurita T、Watanabe S、Ohmori H、Nitta T、Aizawa Y、Kiyono K、Okumura K
    • Journal Title

      Journal of Interventional Cardiac Electrophysiology

      Volume: 49 Issue: 3 Pages: 271-280

    • DOI

      10.1007/s10840-017-0272-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A decision support tool framework to predict adverse outcome in patients with atrial fibrillation: J-Rhythm Registry substudy2019

    • Author(s)
      Watanabe Eiichi
    • Organizer
      ESC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] At Home Study: Safety and Efficacy of the Management of Pacemaker Patients via Home Monitoring versus Conventional In-Office2018

    • Author(s)
      Watanabe E
    • Organizer
      第82回日本循環器学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Feasibility of Switching to Dabigatran on the Day of Catheter Ablation in Atrial Fibrillation Patients Taking Direct Oral2018

    • Author(s)
      Harada M, Watanabe E
    • Organizer
      第82回日本循環器学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Next Generation Sequencing Reveals Intra-cardiac/Extra-cardiac Circulating MicroRNA Transcriptomes in Atrial Fibrillation2018

    • Author(s)
      Harada M, Watanabe E
    • Organizer
      第82回日本循環器学会
    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Presentation] At Home Study: Safety and Efficacy of the Management of Pacemaker Patients via Home Monitoring versus Conventional In-Office Follow-ups2018

    • Author(s)
      Watanabe E
    • Organizer
      第82回日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Feasibility of Switching to Dabigatran on the Day of Catheter Ablation in Atrial Fibrillation Patients Taking Direct Oral Anticoagulants2018

    • Author(s)
      Harada M, Watanabe E
    • Organizer
      第82回日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Prognostic Implication of Selvester QRS Scoring in Atrial Fibrillation Patients with HFrEF Undergoing Catheter Ablation2018

    • Author(s)
      Harada M, Watanabe E
    • Organizer
      第82回日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Skeletal Muscle Proteolysis in Patients with Atrial Fibrillation2018

    • Author(s)
      Harada M, Watanabe E
    • Organizer
      第82回日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Book] はじまりは心房細動2017

    • Author(s)
      奥山 裕司、渡邉 英一
    • Total Pages
      151
    • Publisher
      ライフメディコム
    • ISBN
      9784898132845
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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