Elucidation of the role of Tcf21 in renal fibrosis
| Project/Area Number |
17K09687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹本 稔 千葉大学, 大学院医学研究院, 特任教授 (60447307)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 腎臓線維化 / 転写因子 / Tcf21 / 腎間質 / 腎発生 / 腎臓発生 / 尿管芽 / 腎線維化 / 線維芽細胞 / 細胞外マトリクス |
|---|
| Outline of Final Research Achievements |
Tcf21 belongs to the bHLH transcription factor and is expressed in renal podocytes and stromal cells. Examination of podocyte-specific Tcf21 KO and stroma-specific Tcf21 KO mice shows that Tcf21 is important for maintaining the function of podocytes, and that Tcf21 in stromal cells is essential for tubular differentiation during development. On the other hand, since the significance of Tcf21 in renal fibrosis was unclear, we created a renal interstitial fibrosis model such as unilateral ureteral obstruction and intraperitoneal administration of folic acid in mice in which Tcf21 gene deletion was induced after birth. Suppression of fibrosis-related genes was observed in inducible Tcf21 KO, suggesting that Tcf21 acts as a promoter for fibrosis.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化社会の到来に伴い、腎不全を有する患者の頻度が増加している。腎臓の線維化は、糖尿病腎症や慢性糸球体腎炎など多様な腎疾患の共通する増悪機序であり、その機序解明は新規治療法の開発のために重要な課題である。Tcf21は腎臓における線維化のエフェクター転写因子の一つである可能性があり、その下流遺伝子の同定や、Tcf21の転写貴女の解明は、人選以下の制御につながる可能性がある。
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome2019
Author(s)
Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Kato H, et al.
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Journal Title
Nature Communications
Volume: 10
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] R3hdml regulates satellite cell proliferation and differentiation2019
Author(s)
Sakamoto Kenichi、Furuichi Yasuro、Yamamoto Masashi、Takahashi Megumi、Akimoto Yoshihiro、Ishikawa Takahiro、Shimizu Takahiko、Fujimoto Masanori、Takada‐Watanabe Aki、Hayashi Aiko、Mita Yoshitaka、Manabe Yasuko、Fujii Nobuharu L、Ishibashi Ryoichi、Maezawa Yoshiro、Betsholtz Christer、Yokote Koutaro、Takemoto Minoru
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Journal Title
EMBO reports
Volume: 20
Issue: 11
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development2018
Author(s)
Ide S, Finer G, Maezawa Y, Onay T, Souma T, Scott R, Ide K, Akimoto Y, Li C,Ye M, Zhao X, Baba Y, Minamizuka T, Jin J, Takemoto M, Yokote K, Quaggin SE
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Journal Title
J Am Soc Nephrol
Volume: 29
Issue: 12
Pages: 2795-2808
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients2018
Author(s)
Maezawa Y, Kato H, Takemoto M, Watanabe A, Koshizaka M, Ishikawa T, Sargolzaeiaval F, Kuzuya M, Wakabayashi H, Kusaka T, Yokote K, Oshima J
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Journal Title
Mol Syndromol
Volume: 9
Issue: 4
Pages: 214-218
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immune-mediated acquired lecithin-cholesterol acyltransferase deficiency: A case report and literature review2018
Author(s)
Ishibashi R, Takemoto M, Tsurutani Y, Kuroda M, Ogawa M, Wakabayashi H, Uesugi N, Nagata M, Imai N, Hattori A, Sakamoto K, Kitamoto T, Maezawa Y, Narita I, Hiroi S, Furuta A, Miida T, Yokote K
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Journal Title
J Clin Lipidol
Volume: 12
Issue: 4
Pages: 888-897
DOI
Related Report
Peer Reviewed
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