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Supression of stress-induced senescene in kidney by transplantation of mesenchymal stem cells

Research Project

Project/Area Number 17K09699
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionHiroshima University

Principal Investigator

Masaki Takao  広島大学, 病院(医), 教授 (30397913)

Co-Investigator(Kenkyū-buntansha) 中島 歩  広島大学, 医系科学研究科(医), 共同研究講座教授 (40448262)
土井 盛博  広島大学, 病院(医), 助教 (80626127)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords間葉系幹細胞 / 抗炎症作用 / 線維化 / 再生医療 / ストレス誘導性老化 / マクロファージ / 老化
Outline of Final Research Achievements

Interferon-γ (IFN-γ) stimulation promotes the secretion of prostaglandin E2 from mesenchymal stem cells (MSCs), and increased prostaglandin E2 induces polarization of immunosuppressive CD163-positive macrophages, suppressing the persistence of inflammation. In addition, administration of MSCs treated with IFN-γ more effectively suppressed the p16INK4A positive cells and renal fibrosis than that of control MSCs in a rat ischemia-reperfusion injury model.

Academic Significance and Societal Importance of the Research Achievements

近年、我が国における新規の透析導入患者数は年間4万人を超えている。新規の透析導入患者数を減少させることは、医療費の節減を考えるうえでも非常に重要な課題あるが、腎不全への進行を抑制するための有効な治療法は限られている。間葉系幹細胞を用いた治療法を確立し、臨床応用することが可能になれば、腎障害の進行を遅らせて透析療法を回避させることが期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2019 2017

All Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Presentation] Hypoxia-Preconditioned Mesenchymal Stem Cells Prevent AKI to CKD2019

    • Author(s)
      石内直樹、中島歩、土井盛博、金井亮、土井俊樹、正木崇生
    • Organizer
      American Society of Nephrology Kidney Week 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mesenchymal Stem Cells Cultured in IFN-γ-Containing Medium Ameliorate Experimental Renal Fibrosis2019

    • Author(s)
      金井亮、中島歩、土井盛博、石内直樹、土井俊樹、正木崇生
    • Organizer
      American Society of Nephrology Kidney Week 2019(
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 間葉系幹細胞を用いた腎線維化抑制療法の開発2019

    • Author(s)
      中島歩、加藤幸夫、正木崇生
    • Organizer
      日本透析医学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis by their strong immunosuppressive effects2017

    • Author(s)
      吉田健、中島歩、土井盛博、上野敏憲、加藤幸夫、東幸仁、正木崇生
    • Organizer
      Kidney Week: American Society of Nephrology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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