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A prospective longitudinal study of preclinical CAA in community-dwelling older adults

Research Project

Project/Area Number 17K09795
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKanazawa University

Principal Investigator

Shinohara Moeko  金沢大学, 医薬保健学総合研究科, 特任准教授 (20584832)

Co-Investigator(Kenkyū-buntansha) 山田 正仁  金沢大学, 医学系, 協力研究員 (80191336)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords微小出血 / 認知症 / 脳血管障害 / 海馬 / 糖代謝 / 脳アミロイドアンギオパチー / 海馬容積 / 血糖 / 認知機能 / 脳・神経
Outline of Final Research Achievements

The aims of this study were to clarify the prevalence of asymptomatic cortical microhemorrhage, related local brain atrophy, and blood biomarkers in community-dwelling older people. We showed that the prevalence of asymptomatic cortical microhemorrhage was 2.5% of the older adults with normal cognitive function. The right parahippocampal volume of the people with asymptomatic cortical microhemorrhage showed significantly lower than that of the people without microhemorrhage. Furthermore, the people with asymptomatic cortical microhemorrhage showed significantly higher fasting blood sugar levels, which suggests a relationship between glucose dysmetabolism and asymptomatic cortical microhemorrhage.

Academic Significance and Societal Importance of the Research Achievements

わが国では脳ドックの普及によって無症候だが頭部MRI検査で微小出血が発見される場合も多い。本研究により無症候性皮質微小出血(プレクリニカル皮質微小出血)は認知機能正常の地域在住高齢者の2.5%に認められ、プレクリニカル皮質微小出血群では微小出血なし群に比して、傍海馬容積萎縮をみとめたこと、及び空腹時血糖やグリコアルブミン高値だったことより、皮質微小出血は糖代謝異常を介して認知機能低下と関連する可能性が示唆された。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (56 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 19 results,  Open Access: 13 results) Presentation (30 results) (of which Int'l Joint Research: 3 results,  Invited: 8 results) Book (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Diabetes Mellitus, Elevated Hemoglobin A1c, and Glycated Albumin Are Associated with the Presence of All-Cause Dementia and Alzheimer’s Disease: The JPSC-AD Study2022

    • Author(s)
      Noguchi-Shinohara Moeko、Yuki-Nozaki Sohshi、Abe Chiemi、et al.
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 85 Issue: 1 Pages: 235-247

    • DOI

      10.3233/jad-215153

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors Associated with Self-reported Medication Adherence in Japanese Community-dwelling Elderly Individuals: The Nakajima Study2021

    • Author(s)
      Ishida Natsuko、Tokumoto Yurina、Suga Yukio、Noguchi-Shinohara Moeko、Abe Chiemi、Yuki-Nozaki Sohshi、Mori Ayaka、Horimoto Mai、Hayashi Koji、Iwasa Kazuo、Yokogawa Masami、Ishimiya Mai、Nakamura Hiroyuki、Komai Kiyonobu、Matsushita Ryo、Ishizaki Junko、Yamada Masahito
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 141 Issue: 5 Pages: 751-759

    • DOI

      10.1248/yakushi.20-00254

    • NAID

      130008032758

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2021-05-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease2021

    • Author(s)
      Noguchi-Shinohara Moeko、Koike Masato、Morise Hirofumi、Kudo Kiwamu、Tsuchimine Shoko、Komatsu Junji、Abe Chiemi、Kitagawa Sachiko、Ikeda Yoshihisa、Yamada Masahito
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 11 Pages: e0259677-e0259677

    • DOI

      10.1371/journal.pone.0259677

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of functional variants of vitamin C transporter genes on apolipoprotein E E4-associated risk of cognitive decline: The Nakajima study2021

    • Author(s)
      Hayashi Koji、Noguchi-Shinohara Moeko、Sato Takehiro、et al.
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 11 Pages: e0259663-e0259663

    • DOI

      10.1371/journal.pone.0259663

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebrospinal fluid cytokines and metalloproteinases in cerebral amyloid angiopathy-related inflammation2021

    • Author(s)
      Sakai K, Noguchi-Shinohara M, Ikeda T, Hamaguchi T, Ono K, Yamada M
    • Journal Title

      Acta Neurol Scand

      Volume: 143 Issue: 4 Pages: 450-457

    • DOI

      10.1111/ane.13382

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway.2021

    • Author(s)
      Yamamoto S, Kayama T, Noguchi-Shinohara M, Hamaguchi T, Yamada M, Abe K, Kobayashi S.
    • Journal Title

      npj Science of Food

      Volume: 5 Issue: 1 Pages: 1-1

    • DOI

      10.1038/s41538-021-00084-5

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spontaneous MEG activity of the cerebral cortex during eyes closed and open discriminates Alzheimer’s disease from cognitively normal older adults2020

    • Author(s)
      Ikeda Yoshihisa、Kikuchi Mitsuru、Noguchi-Shinohara Moeko、Iwasa Kazuo、Kameya Masafumi、Hirosawa Tetsu、Yoshita Mitsuhiro、Ono Kenjiro、Samuraki-Yokohama Miharu、Yamada Masahito
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 9132-9132

    • DOI

      10.1038/s41598-020-66034-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diffusion-weighted magnetic resonance imaging in dura mater graft-associated Creutzfeldt-Jakob disease2020

    • Author(s)
      Sakai Kenji、Hamaguchi Tsuyoshi、Sanjo Nobuo、Murai Hiroyuki、Iwasaki Yasushi、Hamano Tadanori、Honma Mari、Noguchi-Shinohara Moeko、Nozaki Ichiro、Nakamura Yosikazu、Kitamoto Tetsuyuki、Harada Masafumi、Mizusawa Hidehiro、Yamada Masahito
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 418 Pages: 117094-117094

    • DOI

      10.1016/j.jns.2020.117094

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer’s disease progression2020

    • Author(s)
      Noguchi-Shinohara Moeko、Ono Kenjiro、Hamaguchi Tsuyoshi、Nagai Toshitada、Kobayashi Shoko、Komatsu Junji、Samuraki-Yokohama Miharu、Iwasa Kazuo、Yokoyama Kunihiko、Nakamura Hiroyuki、Yamada Masahito
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 18627-18627

    • DOI

      10.1038/s41598-020-73729-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Residents living in communities with higher civic participation report higher self-rated health2020

    • Author(s)
      Noguchi-Shinohara Moeko、Hirako Kohei、Tsujiguchi Hiromasa、Itatani Tomoya、Yanagihara Kiyoko、Samuta Hikaru、Nakamura Hiroyuki
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 10 Pages: 0241221-0241221

    • DOI

      10.1371/journal.pone.0241221

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new computerized assessment battery for cognition (C-ABC) to detect mild cognitive impairment and dementia around 5 min2020

    • Author(s)
      Noguchi-Shinohara Moeko、Domoto Chiaki、Yoshida Taketoshi、Niwa Kozue、Yuki-Nozaki Sohshi、Samuraki-Yokohama Miharu、Sakai Kenji、Hamaguchi Tsuyoshi、Ono Kenjiro、Iwasa Kazuo、Matsunari Ichiro、Komai Kiyonobu、Nakamura Hiroyuki、Yamada Masahito
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 12 Pages: e0243469-e0243469

    • DOI

      10.1371/journal.pone.0243469

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rosmarinic acid suppresses Alzheimer’s disease development by reducing amyloid β aggregation by increasing monoamine secretion2019

    • Author(s)
      Hase Tomoki、Shishido Syun、Yamamoto So、Yamashita Rei、Nukima Haruka、Taira Shu、Toyoda Tsudoi、Abe Keiko、Hamaguchi Tsuyoshi、Ono Kenjiro、Noguchi-Shinohara Moeko、Yamada Masahito、Kobayashi Shoko
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8711-8711

    • DOI

      10.1038/s41598-019-45168-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebral hemorrhagic stroke associated with cerebral amyloid angiopathy in young adults about 3 decades after neurosurgeries in their infancy.2019

    • Author(s)
      Hamaguchi T, Komatsu J, Sakai K, Noguchi-Shinohara M, Aoki S, Ikeuchi T, Yamada M
    • Journal Title

      J Neurol Sci

      Volume: 399 Pages: 3-5

    • DOI

      10.1016/j.jns.2019.01.051

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Presence of a Synergistic Interaction Between Current Cigarette Smoking and Diabetes Mellitus on Development of Dementia in Older Adults2019

    • Author(s)
      Noguchi-Shinohara Moeko、Hirako Kohei、Fujiu Makoto、Sagae Masahiko、Samuta Hikaru、Nakamura Hiroyuki、Yamada Masahito
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 71 Issue: 3 Pages: 833-840

    • DOI

      10.3233/jad-190340

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimization of DARTEL settings for the detection of Alzheimer’s disease.2018

    • Author(s)
      Komatsu J, Matsunari I, Samuraki M, Shima K, Noguchi-Shinohara M, Sakai K, Hamaguchi K, Ono K, Matsuda H, Yamada M.
    • Journal Title

      Am J Neuroradiol

      Volume: 39 Issue: 3 Pages: 473-478

    • DOI

      10.3174/ajnr.a5509

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Higher blood vitamin C levels are associated with reduction of apolipoprotein E E4-related risks of cognitive decline in women: the Nakajima Study.2018

    • Author(s)
      Noguchi-Shinohara M, Abe C, Yuki-Nozaki S, Domoto C, Mori A, Hayashi K, Shibata S, Ikeda Y, Sakai K, Iwasa K, Yokogawa M, Ishimiya M, Nakamura H, Yokoji H, Komai K, Nakamura H, Yamada M.
    • Journal Title

      J Alzheimers Dis

      Volume: 63 Issue: 4 Pages: 1289-1297

    • DOI

      10.3233/jad-170971

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multi-center three-year follow-up study.2018

    • Author(s)
      Komatsu J, Samuraki M, Nakajima K, ---, Yamada M.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 89 Issue: 11 Pages: 1167-1173

    • DOI

      10.1136/jnnp-2017-317398

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in Dementia Beliefs between Non-Demented Public Screeners and In-Home Screeners and Their Potential Impact on Future Dementia Screening Intention: The Nakajima Study2018

    • Author(s)
      Yuki-Nozaki Sohshi、Noguchi-Shinohara Moeko、Domoto Chiaki、Ikeda Yoshihisa、Samuraki Miharu、Iwasa Kazuo、Yokogawa Masami、Asai Kimiko、Komai Kiyonobu、Nakamura Hiroyuki、Yamada Masahito
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 62 Issue: 4 Pages: 1651-1661

    • DOI

      10.3233/jad-171177

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tooth loss-related dietary patterns and cognitive impairment in an elderly Japanese population: The Nakajima study2018

    • Author(s)
      Ishimiya Mai、Nakamura Hiroyuki、Kobayashi Yutaka、Noguchi-Shinohara Moeko、Abe Chiemi、Dohmoto Chiaki、Ikeda Yoshihisa、Tokuno Kahori、Ooi Kazuhiro、Yokokawa Masami、Iwasa Kazuo、Komai Kiyonobu、Kawashiri Shuichi、Yamada Masahito
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 3 Pages: 0194504-0194504

    • DOI

      10.1371/journal.pone.0194504

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 増え続ける認知症患者と抗認知症薬の使用ガイダンス2018

    • Author(s)
      篠原もえ子、山田正仁
    • Journal Title

      臨床精神薬理

      Volume: 21 Pages: 357-361

    • Related Report
      2017 Research-status Report
  • [Journal Article] 食品・栄養と認知症予防2017

    • Author(s)
      篠原もえ子、山田正仁
    • Journal Title

      血圧

      Volume: 24 Pages: 114-117

    • Related Report
      2017 Research-status Report
  • [Journal Article] 薬剤誘発性認知症について2017

    • Author(s)
      篠原もえ子、山田正仁
    • Journal Title

      日本薬剤師会雑誌

      Volume: 69 Pages: 1275-1278

    • Related Report
      2017 Research-status Report
  • [Presentation] MCI due to AD診断におけるoptic flowタスクを用いた前頭前野背外側皮質のMEG計測の有用性2022

    • Author(s)
      篠原もえ子、小池暢人、森瀬博史、工藤究、土嶺章子、小松潤史、阿部智絵美、北川幸子、池田芳久、山田正仁、小野賢二郎
    • Organizer
      第24回日本薬物脳波学会(JPEG)& 第38回 日本脳電磁図トポグラフィ研究会(JSBET)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of a C-ABC touch panel cognitive test Germany version and the relationship between social isolation and cognitive decline among elderly: Japan-Germany comparative study2022

    • Author(s)
      Moeko Shinohara, Sohshi Yuki, Natsuko Ishida, Tilmann Supprian, Barbara Hoft, Shingo Shimada, Kenjiro Ono
    • Organizer
      4th Japan-Germany Symposium on Advanced Preventive Medicine 2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 開閉眼及び視覚タスクで誘発される脳磁界によるアルツハイマー病の検出2021

    • Author(s)
      篠原もえ子、池田芳久、山田正仁
    • Organizer
      第30回日本脳ドック学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 糖尿病とアルツハイマー病罹患との関連:JPSC-AD研究2021

    • Author(s)
      篠原もえ子、柚木颯偲、阿部智絵美、森彩香、堀本真以、横川正美、石田奈津子、菅幸生、石﨑純子、石宮舞、中村博幸、駒井清暢、中村裕之、柴田舞欧、小原知之、秦淳、二宮利治、山田正仁、JPSC-AD研究グループ
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 地域高齢者における社会的孤立と主観的認知障害との関連:なかじまプロジェクト研究2021

    • Author(s)
      柚木颯偲、篠原もえ子、阿部智絵美、堀本真以、森彩香、岩佐和夫、駒井清暢、山田正仁
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] COVID-19拡大下の高齢者のこころと活動の変化:なかじまプロジェクト研究2021

    • Author(s)
      堀本真以、篠原もえ子、柚木颯偲、阿部智絵美、森彩香、北 真実、横川正美、羽渕風雅、石田奈津子、菅幸生、石﨑純子、石宮舞、中村博幸、駒井清暢、山田正仁
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 社会ネットワークと認知機能との関連:なかじまプロジェクト研究2021

    • Author(s)
      森彩香、篠原もえ子、柚木颯偲、阿部智絵美、堀本真以、岩佐和夫、駒井清暢、山田正仁
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] MCIの診断におけるOptic flowタスクを用いた前頭前野背外側皮質の脳磁計測の有用性2021

    • Author(s)
      篠原もえ子、小池暢人、森瀬博史、工藤究、土嶺章子、小松潤史、阿部智絵美、北川幸子、池田芳久、山田正仁
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中島町研究に基づく認知症予防法開発の取り組み2020

    • Author(s)
      篠原もえ子
    • Organizer
      第35回日本老年精神医学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] アルツハイマー病による軽度認知障害の診断におけるoptic flowタスクを用いた脳磁計測の有用性2020

    • Author(s)
      篠原もえ子、小池暢人、森瀬博史、工藤究、小松潤史、阿部智絵美、北川幸子、池田芳久
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] アルツハイマー病の診断におけるoptic flowタスクを用いた脳磁測定の有用性2020

    • Author(s)
      小池暢人、森瀬博史、工藤究、小松潤史、阿部智絵美、北川幸子、池田芳久、篠原もえ子、山田正仁
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] アルツハイマー病において言語タスク時の右脳のBroca野相当領域に観測される強い活動2020

    • Author(s)
      小池暢人、森瀬博史、工藤究、小松潤史、阿部智絵美、北川幸子、池田芳久、篠原もえ子、山田正仁
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 地域高齢者における社会的孤立と主観的認知障害との関連:中島町研究2020

    • Author(s)
      柚木颯偲、篠原もえ子、阿部智絵美、堀本真以、森彩香、岩佐和夫、駒井清暢、山田正仁
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 高齢者の昼寝と抑うつに関連する認知機能の縦断的検討2020

    • Author(s)
      阿部智絵美、篠原もえ子、堀本真以、森彩香、柚木颯偲、岩佐和夫、駒井清暢、山田正仁
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Melissa officinalis extract containing rosmarinic acid for Alzheimer’s disease: a randomized, double-blind, placebo-controlled study.2020

    • Author(s)
      Noguchi-Shinohara M, Ono K, Hamaguchi T, Nagai T, Kobayashi S, Komatsu J, Samuraki-Yokohama M, Iwasa K, Yamada M
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 非認知症高齢者におけるpicture namingタスク実施時のERD・ERSの時間周波数解析2020

    • Author(s)
      小池暢人、森瀬博史、工藤究、小松潤史、阿部智絵美、北川幸子、池田芳久、篠原もえ子、山田正仁
    • Organizer
      第35回日本生体磁気学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 認知症コホート研究から(2):中島町研究2019

    • Author(s)
      篠原もえ子、山田正仁
    • Organizer
      第116回日本内科学会総会・講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 抗酸化ビタミン(C・E)と認知症・アルツハイマー病2019

    • Author(s)
      篠原もえ子、山田正仁
    • Organizer
      日本ビタミン学会第71回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Higher blood vitamin C levels are associated with reduced risk of cognitive decline in apolipoprotein E E4-Positive women: The Nakajima Study2019

    • Author(s)
      Shinohara M, Abe C, Yuki-Nozaki S, Dohmoto C, Mori A, Sakai K, Iwasa K, Yokoji H, Komai K, Yamada M
    • Organizer
      Alzheimer’s Association International Conference (AAIC2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 喫煙と糖尿病の認知症リスクと両者の相乗的交互作用2019

    • Author(s)
      篠原もえ子、平子紘平、藤生 慎、寒河江雅彦、佐無田光、山田正仁
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 喫煙と糖尿病の認知症リスクには相乗的交互作用が存在する2019

    • Author(s)
      篠原もえ子、平子紘平、藤生 慎、寒河江雅彦、佐無田光、山田正仁
    • Organizer
      第38回日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Blood vitamin C levels are association with reduction of Apolipoprotein E E4-related risks of cognitive decline in women: the Nakajima study2019

    • Author(s)
      Moeko Shinohara, Masahito Yamada
    • Organizer
      19th Tokyo Metropolitan Institute of Medical Science, International Symposium
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 地域における認知症・軽度認知障害の実態と認知症予防のエビデンス2018

    • Author(s)
      篠原もえ子
    • Organizer
      日本神経学会第5回メディカルスタッフ教育セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ApoE E4陽性女性では血中ビタミンCが将来の認知機能低下の減少と関連する:中島町研究2018

    • Author(s)
      篠原もえ子、阿部智絵美、柚木颯偲、堂本千晶、林幸司、池田芳久、岩佐和夫、横川正美、中村博幸、横地英博、駒井清暢、山田正仁
    • Organizer
      第37回日本認知症学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 血中ビタミンC濃度高値はApoE E4陽性女性の認知機能低下リスクの減少と関連する2018

    • Author(s)
      篠原もえ子、阿部智絵美、柚木颯偲、堂本千晶、林幸司、池田芳久、岩佐和夫、横川正美、中村博幸、横地英博、駒井清暢、山田正仁
    • Organizer
      第59回日本神経学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Early detection, treatment and prevention of dementia in the Nakajima project2017

    • Author(s)
      Noguchi-Shinohara M, Masahito Yamada
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Cerebral amyloid angiopathy-related microbleeds and cerebrospinal fluid biomarkers in Alzheimer’s disease2017

    • Author(s)
      Noguchi-Shinohara M, Komatsu J, Samuraki M, Matsunari I, Ikeda T, Sakai K, Hamaguchi T, Ono K, Nakamura H, Yamada M
    • Organizer
      Alzheimer’s association international conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高齢者における認知機能と昼寝時間および抑うつとの関連2017

    • Author(s)
      阿部智絵美、篠原もえ子、堂本千晶、池田芳久、岩佐和夫、駒井清暢、山田正仁
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 高齢者の社会ネットワークに関連する因子の検討2017

    • Author(s)
      森彩香、篠原もえ子、堂本千晶、池田芳久、岩佐和夫、駒井清暢、山田正仁
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 認知症に関する心理的態度が将来の認知症スクリーニングの受診意欲に及ぼす影響2017

    • Author(s)
      柚木颯偲、篠原もえ子、堂本千晶、池田芳久、佐村木美晴、横川正美、浅井貴美子、岩佐和夫、駒井清暢、中村裕之、山田正仁
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Research-status Report
  • [Book] 地域包括ケアとエリアマネジメント2019

    • Author(s)
      佐無田 光、平子 紘平
    • Total Pages
      280
    • Publisher
      ミネルヴァ書房
    • ISBN
      9784623085095
    • Related Report
      2019 Research-status Report
  • [Book] Curcumin for Neurological and Psychiatric disorders2019

    • Author(s)
      Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Masahito Yamada
    • Total Pages
      495
    • Publisher
      Elsevier
    • ISBN
      9780128154618
    • Related Report
      2018 Research-status Report
  • [Book] 認知症診療実践ハンドブック2017

    • Author(s)
      山田 正仁
    • Total Pages
      368
    • Publisher
      中外医学社
    • ISBN
      9784498228924
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 認知機能検査システム2020

    • Inventor(s)
      山田正仁、篠原もえ子、駒井清暢、岩佐和夫
    • Industrial Property Rights Holder
      山田正仁、篠原もえ子、駒井清暢、岩佐和夫
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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