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Elucidation of Mechanism of tremor brain by the integrated interactive approach

Research Project

Project/Area Number 17K09798
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKyoto University

Principal Investigator

Hitomi Takefumi  京都大学, 医学研究科, 講師 (50402904)

Co-Investigator(Kenkyū-buntansha) 松本 理器  神戸大学, 医学研究科, 教授 (00378754)
小林 勝哉  京都大学, 医学研究科, 特定病院助教 (70737121)
池田 昭夫  京都大学, 医学研究科, 特定教授 (90212761)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords不随意運動 / てんかん / BAFME / 皮質振戦 / 臨床神経生理学 / 振戦脳 / 双方向的解析
Outline of Final Research Achievements

In this research project, we investigated clinical symptom, so called cortical tremor, and electroencephalography and evoked potential in benign adult familial myoclonus epilepsy. Then we performed integrated analysis and disclosed the following findings. 1: Epileptiform discharges, namely cortical irritability, reduced during sleep (Hitomi et al., 2018). 2: The administration of glutamate receptor antagonist caused the change of evoked potential, and the change related to the clinical improvement (Oi et al., 2019). 3: A patient with genetically homozygous BAFME showed progressive clinical course similar to cerebellar degeneration (Kawamura et al., Kinki district meeting of Japan Neurology Society 2019).

Academic Significance and Societal Importance of the Research Achievements

本研究により、良性成人型家族性ミオクローヌスてんかん(BAFME)を標的にした振戦などの不随意運動およびてんかんのメカニズムの解明や治療に関する研究が、成果の通り進みました。研究成果には治療に関する知見も含まれていることから、BAFMEの今後の診療にも役立つものと考えられます。
加えて、上記の解析方法やえられた知見は、皮質ミオクローヌスや本態性振戦など他の不随意運動における病態解明・新規治療法導入時の評価法にも応用できると考えられます。以上より、本研究は不随意運動の診療全体にも大きく役立つと考えられます。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (25 results)

All 2020 2019 2018 2017

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 6 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Scalp-EEG could record both ictal DC shift and HFO together even with time constant 2 sec2020

    • Author(s)
      Tomohiko Murai, Takefumi Hitomi, Masao Matsuhashi, Riki Matsumoto, Yuki Kawamura, Masutaro Kanda, Ryosuke Takahashi, Akio Ikeda
    • Journal Title

      Journal of Clinical Neurophysiology

      Volume: 37 Issue: 2 Pages: 191-194

    • DOI

      10.1097/wnp.0000000000000670

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rational, multispectral mapping algorithm for primary motor cortex: A primary step before cortical stimulation2019

    • Author(s)
      Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Takefumi Hitomi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto, Susumu Miyamoto, Ryosuke Takahashi, Hirofumi Maruyama, Akio Ikeda
    • Journal Title

      Epilepsia

      Volume: 60 Issue: 3 Pages: 547-559

    • DOI

      10.1111/epi.14669

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low-dose perampanel improves refractory cortical myoclonus by the dispersed and suppressed paroxysmal depolarization shifts in the sensorimotor cortex2019

    • Author(s)
      Kazuki Oi, Shuichiro Neshige, Takefumi Hitomi, Katsuya Kobayashi, Masao Matsuhashi, Akihiro Shimotake, Daiki Fujii, Riki Matsumoto, Shuhei Kasama, Masutaro Kanda, Yoshiaki Wada, Hirofumi Maruyama, Ryosuke Takahashi, Akio Ikeda
    • Journal Title

      Clinical Neurophysiology

      Volume: 130 Issue: 10 Pages: 1804-1812

    • DOI

      10.1016/j.clinph.2019.07.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A score to map the lateral non-primary motor area: multi-spectrum intrinsic brain activity vs. cortical stimulation2019

    • Author(s)
      Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Masaya Togo, Mitsuhiro Sakamoto, Akihiro Shimotake, Takefumi Hitomi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto, Hirofumi Maruyama, Ryosuke Takahashi, Susumu Miyamoto, Akio Ikeda
    • Journal Title

      Epilepsia

      Volume: 60 Issue: 11 Pages: 2294-2305

    • DOI

      10.1111/epi.16367

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation.2019

    • Author(s)
      Usami K, Korzeniewska A, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Kunieda T, Mikuni N, Kikuchi T, Yoshida K, Miyamoto S, Takahashi R, Ikeda A, Crone NE.
    • Journal Title

      Sleep.

      Volume: in press Issue: 6 Pages: 1-9

    • DOI

      10.1093/sleep/zsz050

    • NAID

      120006647295

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Progressive Restrictive Ventilatory Impairment in Idiopathic Diffuse Pulmonary Ossification2018

    • Author(s)
      Matsuo H, Handa T, Tsuchiya M, Kubo T, Yoshizawa A, Nakayama Y, Shiga S, Hitomi T, Adachi S, Date H, Hirai T, Ichiyama S.
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 11 Pages: 1631-1636

    • DOI

      10.2169/internalmedicine.9433-17

    • NAID

      130007382812

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-06-01
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interictal Slow and High-Frequency Oscillations: Is it an Epileptic Slow or Red Slow?2018

    • Author(s)
      Inoue T, Inouchi M, Matsuhashi M, Matsumoto R, Hitomi T, Daifu-Kobayashi M, Kobayashi K, Nakatani M, Kanazawa K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
    • Journal Title

      J Clin Neurophysiol.

      Volume: 36 Issue: 2 Pages: 166-170

    • DOI

      10.1097/wnp.0000000000000527

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy2018

    • Author(s)
      Ishiura Hiroyuki、Doi Koichiro、Mitsui Jun、Yoshimura Jun、Matsukawa Miho Kawabe、Takahashi Yuji、Date Hidetoshi、Matsukawa Takashi、Shimizu Jun、Koh Kishin、Takiyama Yoshihisa、Goto Jun、Morishita Shinichi、Tsuji Shoji
    • Journal Title

      Nature Genetics

      Volume: 50 Issue: 4 Pages: 581-590

    • DOI

      10.1038/s41588-018-0067-2

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery.2018

    • Author(s)
      Neshige S, Matsuhashi M, Kobayashi K, Sakurai T, Shimotake A, Hitomi T, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Miyamoto S, Maruyama H, Matsumoto M, Ikeda A.
    • Journal Title

      Clin Neurophysiol.

      Volume: 129 Issue: 9 Pages: 2038-2048

    • DOI

      10.1016/j.clinph.2018.06.007

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey in Japan endorsed diagnostic criteria of benign adult familial myoclonus epilepsy.2018

    • Author(s)
      Kobayashi K, Hitomi T, Matsumoto R, Watanabe M, Takahashi R, Ikeda A.
    • Journal Title

      Seizure.

      Volume: 61 Pages: 14-22

    • DOI

      10.1016/j.seizure.2018.07.014

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Short "Infraslow" Activity (SISA) With Burst Suppression in Acute Anoxic Encephalopathy: A Rare, Specific Ominous Sign With Acute Posthypoxic Myoclonus or Acute Symptomatic Seizures.2018

    • Author(s)
      Togo M, Hitomi T, Murai T, Yoshimura H, Matsuhashi M, Matsumoto R, Kawamoto M, Kohara N, Takahashi R, Ikeda A.
    • Journal Title

      J Clin Neurophysiol.

      Volume: 35 Issue: 6 Pages: 496-503

    • DOI

      10.1097/wnp.0000000000000507

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy.2018

    • Author(s)
      Hitomi T, Inouchi M, Takeyama H, Kobayashi K, Sultana S, Inoue T, Nakayama Y, Shimotake A, Matsuhashi M, Matsumoto R, Chin K, Takahashi R, Ikeda A.
    • Journal Title

      Epilepsy Behav Case Rep.

      Volume: 11 Pages: 18-21

    • DOI

      10.1016/j.ebcr.2018.09.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study.2017

    • Author(s)
      Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
    • Journal Title

      Sleep

      Volume: 40 Issue: 8 Pages: 1-7

    • DOI

      10.1093/sleep/zsx077

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Voice Therapy on Laryngeal Motor Units During Phonation in Chronic Superior Laryngeal Nerve Paresis Dysphonia.2017

    • Author(s)
      Kaneko M, Hitomi T, Takekawa T, Tsuji T, Kishimoto Y, Hirano S.
    • Journal Title

      J Voice.

      Volume: in press Issue: 6 Pages: 729-733

    • DOI

      10.1016/j.jvoice.2017.08.026

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] No or little progression of EEG abnormality in genetically proven in benign adult familial myoclonus epilepsy (BAFME).2019

    • Author(s)
      Hitomi T, Neshige S, Tojima M, Kobayashi K, Oi K, Murai M, Shamima S, Shimotake A, Matsumoto R, Takahashi R, Ikeda A
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A homozygotic mutation with severe benign adult familial myoclonus epilepsy (BAFME).2018

    • Author(s)
      Hitomi T, Kobayashi K, Sakurai T, Murai T, Sultana S, Kinoshita M, Shimotake A, Matsumoto R, Takahashi R, Ikeda A.
    • Organizer
      12th Asian & Oceanian Epilepsy Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Temporal change of electroencephalogram in benign adult familial myoclonus epilepsy (BAFME).2018

    • Author(s)
      Hitomi T, Kobayashi K, Neshige S, Sultana S, Sato K, Shimotake A, Matsumoto R, Takahashi R, Ikeda A.
    • Organizer
      12th Asian & Oceanian Epilepsy Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 良性成人型家族性ミオクローヌスてんかんにおける脳波所見の経時的変化。2018

    • Author(s)
      人見健文、小林勝哉、音成秀一郎、Shamima Sultana、佐藤啓、谷岡洸介、下竹昭寛、松本理器、高橋良輔、池田昭夫
    • Organizer
      第59回日本神経学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 良性成人型家族性ミオクローヌスてんかん(BAFME)における原因遺伝子のリピート数と神経生理学的所見の関係。2018

    • Author(s)
      人見健文、音成秀一郎、小林勝哉、戸島麻耶、大井和起、下竹昭寛,松橋眞生,松本理器、神田益太郎、石浦浩之、辻省次、高橋良輔、池田昭夫
    • Organizer
      第52回日本てんかん学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 遺伝子検査陽性の良性成人型家族性ミオクローヌスてんかん(BAFME)における巨大体性感覚誘発電位(巨大SEP)とC反射の陽性率。2018

    • Author(s)
      人見健文、音成秀一郎、小林勝哉、松本理器、高橋良輔、池田昭夫
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 良性成人型家族性ミオクローヌスてんかん(BAFME)。 シンポジウム 高齢者てんかんと脳波2018

    • Author(s)
      人見健文、小林勝哉、音成秀一郎、高橋良輔、池田昭夫
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Positive rate of giant somatosensory evoked potential (giant SEP) and C reflex in benign adult familial myoclonus epilepsy (BAFME).2017

    • Author(s)
      Hitomi T, Kobayashi K, Murai T, Sakurai T, Matsumoto R, Takahashi R, Ikeda A.
    • Organizer
      17th World Congress of Neurology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 遠隔脳波判読。シンポジウム6遠隔医療(脳波とテレメディスン)2017

    • Author(s)
      人見健文、谷岡洸介、高橋良輔、池田昭夫
    • Organizer
      第51回日本てんかん学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 日本の地域レベルでの遠隔脳波判読の取り組みの現状と問題点。シンポ2017

    • Author(s)
      人見健文、谷岡洸介、高橋良輔、池田昭夫
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 所見の解釈と脳波レポートの作成 1基礎篇。モノグラフ 臨床脳波を基礎から学ぶ人のために 第2版:64-712019

    • Author(s)
      人見健文、池田昭夫
    • Total Pages
      253
    • Publisher
      診断と治療社
    • ISBN
      9784787824455
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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