Study of pathogenesis caused by hypouricemia in multiple system atrophy
| Project/Area Number |
17K09805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KOYANO Shigeru 横浜市立大学, 医学研究科, 客員教授 (50315818)
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| Co-Investigator(Kenkyū-buntansha) |
田中 章景 横浜市立大学, 医学研究科, 教授 (30378012)
多田 美紀子 横浜市立大学, 医学部, 助教 (30722467)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 多系統萎縮症 / 尿酸 / 酸化ストレス / 尿酸トランスポーター / 活性酸素 |
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| Outline of Final Research Achievements |
The relationship between neurological diseases and uric acid levels has been reported. Especially for diseases associated with oxidative stress, low levels of uric acid, which has an antioxidant effect, may be associated with the pathogenesis. Multiple system atrophy(MSA) is a disease whose pathological mechanism is associated with oxidative stress. In this study, we analyzed the involvement of uric acid in MSA from a clinical and pathological perspective. Examination of the relationship between serum and cerebrospinal fluid uric acid levels and various clinical data showed that the higher the uric acid level, the slower the progression of the disease. From a neuropathological study, uric acid immunoreactivity was weak in general part in brain of MSA. By contrast, dityrosine immunoreactivity in MSA was prominently observed in neurons, glia are related to the pathological lesions of MSA. These observations suggest the relevance of tyrosine oxidative stress in the pathomechanism of MSA.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究を通じ、活性酸素に関わる神経疾患である多系統萎縮症が低尿酸血症による抗酸化作用の低下によって病態形成に係わることを明らかにすることは極めて重要な意義を持ち、これまで明らかにされなかった多系統萎縮症の病態解明へ一歩になるとともに、他の活性酸素が関連する神経疾患の共通の病態解明への手がかりになることが予想される。さらに、病態に尿酸トランスポーターが関与していることを利用すれば、多系統萎縮症の新規治療法開発への希望につながる可能性がある。
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Report
(4 results)
Research Products
(1 results)
