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chronic cerebral ischemia and amyloid deposition

Research Project

Project/Area Number 17K09814
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionResearch Institute, Shiga Medical Center

Principal Investigator

Yamauchi Hiroshi  滋賀県立総合病院(研究所), 画像研究部門, 副所長 (40360812)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords慢性脳虚血 / アミロイド / 分子イメージング / PET / ポジトロンCT / 脳血管障害 / ポジトロンCT / 脳神経疾患 / 痴呆 / 脳卒中
Outline of Final Research Achievements

Amyloid plaque formation is a core pathological features of Alzheimer disease. Although experimental studies have shown that global cerebral hypoperfusion leads to amyloid deposition in the hemisphere with carotid artery occlusion in rodents, the results of such occurrence are controversial in humans. In this study, we demonstrated that global cerebral hypoperfusion leading to decreased blood flow relative to metabolic demand [increased oxygen extraction fraction (OEF), misery perfusion] is associated with increases in amyloid deposition in the hemisphere with atherosclerotic major cerebral artery disease in patients. Cerebral hypoperfusion may contribute to amyloid deposition in humans. Optimal management of vascular risk factors can prevent chronic cerebral hypoperfusion, which may delay progression of Alzheimer disease.

Academic Significance and Societal Importance of the Research Achievements

アルツハイマー病と脳血管障害は共通の危険因子を有しており、修正可能な脳血管障害危険因子の治療は、アルツハイマー病発症予防や進行遅延のために重要である。慢性脳虚血と関連したアミロイド蓄積増加の存在を明らかしたことで、動物実験で推察されてきた、慢性脳虚血がアルツハイマー病の発症あるいは進行に影響するという仮説をヒトで検証できた。慢性脳虚血は、外科的あるいは内科的に治療できることから、アミロイド蓄積による神経細胞死、および認知機能障害の治療法を探索する上で重要である。本研究は、アルツハイマー病の発症あるいは進行に対する、慢性脳虚血をふくめた脳血管危険因子管理の重要性に関して臨床医の認識を高める。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (5 results) (of which Invited: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] <p>Spatial Patterns of Amyloid Deposition in Patients with Chronic Focal or Diffuse Traumatic Brain Injury Using <sup>18</sup>F-FPYBF-2 PET</p>2020

    • Author(s)
      Ubukata Shiho、Oishi Naoya、Higashi Tatsuya、Kagawa Shinya、Yamauchi Hiroshi、Okuyama Chio、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Aso Toshihiko、Murai Toshiya、Ueda Keita
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 16 Pages: 2719-2732

    • DOI

      10.2147/ndt.s268504

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selective neuronal damage and blood pressure in atherosclerotic major cerebral artery disease.2019

    • Author(s)
      1.Yamauchi H, Kagawa S, Takahashi M, Kusano K, Okuyama C.
    • Journal Title

      J Neuro Neurosurg Psychiatry

      Volume: 90 Issue: 9 Pages: 975-980

    • DOI

      10.1136/jnnp-2019-320326

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease2019

    • Author(s)
      Yamauchi Hiroshi、Kagawa Shinya、Takahashi Masaaki、Oishi Naoya、Ono Masahiro、Higashi Tatsuya
    • Journal Title

      NeuroImage: Clinical

      Volume: 22 Pages: 101762-101762

    • DOI

      10.1016/j.nicl.2019.101762

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia2018

    • Author(s)
      Higashi Tatsuya、Nishii Ryuichi、Kagawa Shinya、Kishibe Yoshihiko、Takahashi Masaaki、Okina Tomoko、Suzuki Norio、Hasegawa Hiroshi、Nagahama Yasuhiro、Ishizu Koichi、Oishi Naoya、Kimura Hiroyuki、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Yamauchi Hiroshi
    • Journal Title

      Ann Nucl Med

      Volume: 32 Issue: 3 Pages: 206-216

    • DOI

      10.1007/s12149-018-1236-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer: biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging2018

    • Author(s)
      Nishii Ryuichi、Higashi Tatsuya、Kagawa Shinya、Okuyama Chio、Kishibe Yoshihiko、Takahashi Masaaki、Okina Tomoko、Suzuki Norio、Hasegawa Hiroshi、Nagahama Yasuhiro、Ishizu Koichi、Oishi Naoya、Kimura Hiroyuki、Watanabe Hiroyuki、Ono Masahiro、Saji Hideo、Yamauchi Hiroshi
    • Journal Title

      Ann Nucl Med

      Volume: 32 Issue: 4 Pages: 256-263

    • DOI

      10.1007/s12149-018-1240-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term hemodynamic changes and blood pressure in atherosclerotic major cerebral artery disease2018

    • Author(s)
      Yamauchi H, Kagawa S, Takahashi M, Higashi T.
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: 印刷中 Issue: 2 Pages: 324-331

    • DOI

      10.1177/0271678x17727385

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] FMZ-PET to assess the efficacy and the mechanism of ketogenic diet in patients with intractable epilepsy2018

    • Author(s)
      Nishii R, Hirai T, Fujii T, Kumada T, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Okuyama C, Nagamachi S.
    • Journal Title

      Imaging in Medicine

      Volume: 10(1)

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progressive Cortical Neuronal Damage and Extracranial-Intracranial Bypass Surgery in Patients with Misery Perfusion2017

    • Author(s)
      5.Yamauchi H, Kagawa S, Kishibe Y, Takahashi M, Higashi T.
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 38 Pages: 935-941

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳循環障害の早期発見と認知症予防2020

    • Author(s)
      山内浩
    • Organizer
      第39回日本認知症学会学術集会.
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 貧困灌流とアミロイド蓄積2020

    • Author(s)
      山内浩
    • Organizer
      第63回日本脳循環代謝学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] アテローム硬化性脳主幹動脈閉塞性疾患における血圧低値と選択的神経細胞障害2019

    • Author(s)
      山内 浩,加川信也、高橋昌章、草野邦典、奥山智緒
    • Organizer
      第62回日本脳循環代謝学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] アテローム硬化性脳主幹動脈閉塞性疾患における貧困灌流とアミロイド蓄積増加2019

    • Author(s)
      山内 浩,加川信也、高橋昌章、草野邦典、奥山智緒
    • Organizer
      第38回日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 脳小血管病を合併した主幹脳動脈病変患者の脳循環障害2017

    • Author(s)
      山内 浩
    • Organizer
      第60回日本脳循環代謝学会学術集会
    • Related Report
      2017 Research-status Report
  • [Book] Imaging of Central Benzodiazepine Receptors in Chronic Cerebral Ischemia. In: Dierckx R.A., Otte A., de Vries E.F., van Waarde A., Lammertsma A.A. (eds) PET and SPECT of Neurobiological Systems.2020

    • Author(s)
      Yamauchi H.
    • Publisher
      Springer, Cham.
    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      http://www.shigamed.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 滋賀県立総合病院研究所

    • URL

      http://www.shigamed.jp/

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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