| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Thyrotropin-releasing hormone (TRH) in the hypothalamic paraventricular nucleus has been reported to be crucial for the hypothalamic (TRH)-pituitary (TSH)-thyroid axis and the leptin-induced stimulation of blood thyroid hormone in mice. However, TRH is known to be distributed not only hypothalamic paraventricular nucleus but also whole hypothalamus as well as whole brain and body. To gain further insight into significance of paraventricular nucleus (PVN) we established paraventricular specific TRH knock out mice by mating floxed TRH gene mice and Sim1-Cre mice showing deletion of preproTRH gene in paraventricular region. These Sim1-Cre;TRHflox/flox mice showed tertiary hypothyroidism just like null TRH deficient mice, showing mild hypothyroidism with slightly elevated serum TSH levels. These findings further support evidence of TRH in PVN was crucial for H-P-T axis.
|
