| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Mitochondria sense the nutritional status of living body, constantly changing the balance between fusion and fission, and dynamically changing its structure. Mitochondrial dynamics is involved in energy metabolism and chronic inflammation. Mitochondrial dynamics functions as an energy sensor in hepatocytes and regulates systemic metabolism by increasing insulin sensitivity in peripheral tissues such as adipose tissue and skeletal muscle through FGF21 expression. In addition, mitochondrial dynamics regulates innate immunity via autophagy, and its disorder leads to chronic inflammation. In summary, mitochondrial dynamics is a molecular mechanism that links metabolism and inflammation.
|
