Mitochondrial dynamics regulating energy metabolism and chronic inflammation.
Project/Area Number |
17K09885
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Kurume University |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ミトコンドリアダイナミクス / 糖尿病 / DRP1 / インスリン感受性 / 小胞体ストレス / オートファジー / 慢性炎症 / NASH / MFF / 炎症 / 非アルコール性脂肪肝炎 / FGF21 / マクロファージ / Drp1 / Mff |
Outline of Final Research Achievements |
Mitochondria sense the nutritional status of living body, constantly changing the balance between fusion and fission, and dynamically changing its structure. Mitochondrial dynamics is involved in energy metabolism and chronic inflammation. Mitochondrial dynamics functions as an energy sensor in hepatocytes and regulates systemic metabolism by increasing insulin sensitivity in peripheral tissues such as adipose tissue and skeletal muscle through FGF21 expression. In addition, mitochondrial dynamics regulates innate immunity via autophagy, and its disorder leads to chronic inflammation. In summary, mitochondrial dynamics is a molecular mechanism that links metabolism and inflammation.
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Academic Significance and Societal Importance of the Research Achievements |
我国は高齢社会を迎え、糖尿病、肥満、NASHといった生活習慣病が急増し、その克服は健康寿命の延伸に不可欠である。過栄養の結果、自然免疫応答により慢性炎症が生じる。本研究は、代謝恒常性維持機構をオルガネラネットワークの視点から捉えた極めて独創性が高い研究であり、ミトコンドリアダイナミクスが生活習慣病に共通の分子基盤である慢性炎症を制御していることを明らかにした。ミトコンドリアダイナミクスが広範な細胞機能を制御し、生命現象の基盤をなす動作原理である。ミトコンドリアダイナミクスを標的とした生活習慣病の予防法さらには革新的医薬品開発につながる蓋然性が極めて高く、社会的意義も大きい。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] The expanding phenotype of hypokalemic periodic paralysis in a Japanese family with p.Val876Glu mutation in CACNA1S.2020
Author(s)
Kurokawa M, Torio M, Ohkubo K, Tocan V, Ohyama N, Toda N, Ishii K, Nishiyama K, Mushimoto Y, Sakamoto R, Nakaza M, Horie R, Kubota T, Takahashi MP, Sakai Y, Nomura M, Ohga S.
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Journal Title
Mol Genet Genomic Med
Volume: -
Issue: 4
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bromocriptine as a Potential Glucose-lowering Agent for the Treatment of Prolactinoma with Type 2 Diabetes2019
Author(s)
Ohshige T, Nakamura Y, Sasaki Y, Kawano S, Ohki T, Tsuruta M, Tokubuchi I, Nakayama H, Yamada K, Ashida K, Tajiri Y, Nomura M
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Journal Title
Internal Medicine
Volume: 58
Issue: 21
Pages: 3125-3128
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2019-11-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] Metreleptin Supplementation for Improving Lipid and Glycemic Profiles in Acquired Diabetes Lipodystrophy: A Case Report.2019
Author(s)
Nagayama A, Ashida K, Moritaka K, Hidaka M, Gobaru M, Tanaka S, Hasuzawa N, Akasu S, Goto Y, Motomura S, Hara K, Tsuruta M, Wada N, Nakayama H, Tajiri Y, Nomura M.
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Journal Title
J Endocrinology Soc
Volume: 3
Issue: 11
Pages: 2179-2183
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A High-Fat/High-Sucrose Diet Induces WNT4 Expression in Mouse Pancreatic β-cells2018
Author(s)
Kurita Y, Ohki T, Soejima E, Yuan X, Kakino S, Wada N, Hashinaga T, Nakayama H, Tani J, Tajiri Y, Hiromatsu Y, Yamada K, Nomura M.
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Journal Title
The Kurume Medical Journal
Volume: 65
Issue: 2
Pages: 55-62
DOI
NAID
ISSN
0023-5679, 1881-2090
Year and Date
2018-06-30
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids2018
Author(s)
Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Yasuhiro Ishihara, Ju-Yeon Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima, Lixiang Wang, Ryuichiro Sato, Takeshi Yamazaki, Mikita Suyama, Masatoshi Nomura, Man Ho Choi, Yasuyuki Ohkawa & Ken-ichirou Morohashi
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Journal Title
Communications Biology
Volume: 1
Issue: 1
Pages: 1-9
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.2018
Author(s)
Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
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Journal Title
iScience
Volume: 6
Pages: 306-318
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults.2018
Author(s)
Abe M, Shivappa N, Ito H, Oze I, Abe T, Shimizu Y, Hasegawa Y, Kiyohara C, Nomura M, Ogawa Y, Hebert JR, Matsuo K.
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Journal Title
Oncotarget
Volume: 9
Issue: 35
Pages: 24028-24040
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Efficacy and safety of metyrosine in pheochromocytoma/paraganglioma: a multi-center trial in Japan2018
Author(s)
Naruse M, Satoh F, Tanabe A, Okamoto T, Ichihara A, Tsuiki M, Katabami T, Nomura M, Tanaka T, Matsuda T, Imai T, Yamada M, Harada T, Kawata N, Takekoshi K.
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Journal Title
Endocrine Journal
Volume: 65
Issue: 3
Pages: 359-371
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium.2017
Author(s)
Eritja N, Felip I, Dosil MA, Vigezzi L, Mirantes C, Yeramian A, Navaridas R, Santacana M, Llobet-Navas D, Yoshimura A, Nomura M, Encinas M, Matias-Guiu X, Dolcet X.
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Journal Title
Cell Death Differ.
Volume: 24
Issue: 8
Pages: 1443-1458
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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