Analysis of association between adverse events and radiosensitivity genes in proton therapy for pediatric cancers

• Project/Area Number: 17K10096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Saitama Medical University (2022); Dokkyo Medical University (2018-2021); University of Tsukuba (2017)
• Principal Investigator: Nakao Tomohei 埼玉医科大学, 医学部, 准教授 (20554885)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 小児がん / 陽子線治療 / precision medicine / 有害事象 / 遺伝子多型 / 放射線感受性遺伝子 / 急性期有害事象 / 治療関連 / 遺伝学

Outline of Final Research Achievements

We analyzed adverse events and quality of life (QOL) in 60 children treated with proton therapy to the head and neck region, and reported that the treatment contributed to reduced adverse events and improved QOL compared with conventional X-ray therapy. We analyzed short-term adverse events in 15 patients with Ewing's sarcoma, 18 patients with neuroblastoma, and 4 patients with rhabdomyosarcoma who were transferred between institutions for proton therapy while receiving high-intensity chemotherapy, and reported in a conference report and a paper that it was possible to receive proton therapy while transferring between institutions without an increase in adverse events.

Academic Significance and Societal Importance of the Research Achievements

小児がんの治療を実施できる、数少ない国内の陽子線治療施設として小児がんに対する集学的治療における陽子線治療の急性期有害事象の集積および解析を実施・報告することにより、今後さらに需要が高まると考えられる小児がんに対する粒子線治療の社会的意義および有効性、安全性についての情報が提供できた。さらに、現在進められているprecision medicineの実効性を考慮するにあたり、粒子線治療の個別的な安全性についてのデータを集積・解析した。

Research Products

• [Journal Article] Effect of Germline MEFV Polymorphisms on the Prognosis of Japanese Children with Cancer: A Regional Analysis (2022)
  • Author(s): Hasegawa Morio、Fukushima Hiroko、Suzuki Ryoko、Yamaki Yuni、Hosaka Sho、Inaba Masako、Nakao Tomohei、Kobayashi Chie、Yoshimi Ai、Tsuchida Masahiro、Koike Kazutoshi、Fukushima Takashi、Takada Hidetoshi
  • Journal Title: Oncology Volume: 100 Issue: 7 Pages: 376-383
  • DOI: 10.1159/000524833
  • Peer Reviewed
• [Journal Article] Urgent Proton Beam Therapy With Interinstitutional Transfer for Patients With Intracranial Rhabdomyosarcoma: Report of 3 Cases. (2020)
  • Author(s): Inaba M, Nakao T, Hosaka S, Suzuki R, Fukushima H, Yamaki Y, Saito T, Sakashita S, Noguchi M, Minami M, Masumoto T, Mizumoto M, Sakurai H, Fukushima T, Takada H
  • Journal Title: Journal of Pediatric Hematology / Oncology Volume: 42 Issue: 1 Pages: e12-e17
  • DOI: 10.1097/mph.0000000000001620
  • Peer Reviewed
• [Journal Article] Patient Transfer to Receive Proton Beam Therapy During Intensive Multimodal Therapy is Safe and Feasible for Patients With Newly Diagnosed High-risk Neuroblastoma. (2020)
  • Author(s): Hosaka S, Fukushima H, Nakao T, Suzuki R, Yamaki Y, Tanaka K, Saito T, Mizumoto M, Sakurai H, Fukushima T, Takada H
  • Journal Title: Journal of Pediatric Hematology / Oncology Volume: 42 Issue: 1 Pages: e18-e24
  • DOI: 10.1097/mph.0000000000001570
  • Peer Reviewed
• [Journal Article] Interinstitutional patient transfers between rapid chemotherapy cycles were feasible to utilize proton beam therapy for pediatric Ewing sarcoma family of tumors. (2018)
  • Author(s): Nakao T, Fukushima H, Fukushima T, Suzuki R, Hosaka S, Yamaki Y, Kobayashi C, Iwabuchi A, Imagawa K, Sakai A, Shinkai T, Masumoto K, Sakashita S, Masumoto T, Mizumoto M, Sumazaki R, Sakurai H
  • Journal Title: Reports of Practical Oncology and Radiotherapy Volume: 23 Issue: 5 Pages: 442-450
  • DOI: 10.1016/j.rpor.2018.08.006
  • Peer Reviewed
• [Journal Article] Comorbidity and quality of life in childhood cancer survivors treated with proton beam therapy. (2017)
  • Author(s): Fukushima H, Fukushima T, Suzuki R, Iwabuchi A, Hidaka K, Shinkai T, Masumoto K, Muroi A, Yamamoto T, Nakao T, Oshiro Y, Mizumoto M, Sakurai H, Sumazaki R
  • Journal Title: Pediatrics International Volume: 59 Issue: 10 Pages: 1039-1045
  • DOI: 10.1111/ped.13323
  • Peer Reviewed
• [Presentation] Assessment of space-making radiation therapy in pediatric patients with tumors (2020)
  • Author(s): Michi Kamei, Hiromitsu Iwata, Kouji Masumoto, Tomohei Nakao, Yusuke Demizu, Reiko Imai, Daisuke Takagi, Shigehisa Fumino, Etsuyo Ogo , Ryohei Sasaki
  • Organizer: 第62回日本小児血液・がん学会学術集会
• [Presentation] Sedation with single use of thiamylal is feasible compared with ketamine plus midazolam for proton beam therapy. (2018)
  • Author(s): Masako I, Nakao T, Yoshimura Y, Hosaka S, Tao K, Suzuki R, Fukushima H, Yamaki Y, Yamashita S, Mizumoto M, Sakurai H, Fukushima T, Takada H.
  • Organizer: 第60回日本小児血液・がん学会学術集会
• [Presentation] 初発神経芽腫に対する集学的治療中に陽子線治療目的で当院へ移動した症例の安全性の検討 (2017)
  • Author(s): 穂坂翔、中尾朋平、鈴木涼子、八牧愉二、福島紘子、斎藤高、水本斉志、櫻井英幸、増本幸二、福島敬、稲葉正子、南学、増本智彦、野口雅之、坂下信悟、中野雅之
  • Organizer: 第59回日本小児血液・がん学会学術集会
• [Presentation] 頭蓋内進展を伴う頭頚部腫瘍に対し緊急陽子線治療併用化学療法を行った4例の検討 (2017)
  • Author(s): 稲葉正子、中尾朋平、穂坂翔、鈴木涼子、福島紘子、八牧愉二、斎藤高、野口雅之、坂下信悟、南学、増本智彦、湯坐有希、松井基浩、足立壮一、菊田敦、水本斉志、櫻井英幸、福島敬
  • Organizer: 第59回日本小児血液・がん学会学術集会