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Long-term impact of ART on immune status of HIV-infected children

Research Project

Project/Area Number 17K10100
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKanazawa University

Principal Investigator

BI Xiuqiong  金沢大学, 医学系, 助教 (50565413)

Co-Investigator(Kenkyū-buntansha) 市村 宏  金沢大学, 医学系, 教授 (10264756)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsHIV / ART / 小児 / 免疫状態 / HIV感染 / 抗HIV療法 / 免疫
Outline of Final Research Achievements

This study investigated the impact of ART on the immune status of HIV-infected Vietnamese children. The differentiation of CD4 and CD8 cells, Th1/Th2/Th17/Treg subsets, and CD8 T cell activation were analyzed twice a year and compared to those of HIV-uninfected children.
After ART initiation, the CD4 cell counts including the CD4-RTE (recent thymic emigrants)/-naive/-cm (central memory)/-em (effector memory) and Th1 subsets, and the CD8-naive/-cm subset counts significantly increased and reached the HIV(─) children’s range by 6 months. The CD4-emra (emCD45RA+) and Th2/Th17/Treg, the activated CD8 cells, the CD8-em/-emra subsets, the CD4/CD8 ratio normalized within 4 years. The younger children showed better increase of CD4 counts at 6 months of ART. ART induced an early recovery of thymic function in HIV-infected children and lead to the early recovery of CD4 and CD8 naive subsets. Early diagnose of HIV infection followed by early ART is important for HIV administration in children.

Academic Significance and Societal Importance of the Research Achievements

本研究では、ベトナムの小児において、HIV感染小児の免疫状態が生後1-2か月から胸腺機能を含む異常状態になっていたことが示された。また、ART開始後、胸腺機能は6ヶ月までに回復し、CD4とCD8のnaive サブセットとTh1も早期に回復したが、他のCD4とCD8細胞のサブセットとCD8 T細胞の活性化の正常化は1-4年の治療が必要であった。更に、ART開始前の年齢は小さく、CD4細胞数が高いほどART開始後6ヶ月のCD4細胞増加数が多く、回復がよかった。小児において、HIV感染の早期診断、そしてARTの早期導入がHIV感染管理に重要である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] ハノイ国立小児病院(ベトナム)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ハノイ国立小児病院(ベトナム)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ハノイ・ベトナム国立小児病院(ベトナム)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Newly emerged enterovirus-A71 C4 sublineage may be more virulent than B5 in the 2015?2016 hand-foot-and-mouth disease outbreak in northern Vietnam2020

    • Author(s)
      Chu Son T.、Kobayashi Kyousuke、Bi Xiuqiong、Ishizaki Azumi、Tran Tu T.、Phung Thuy T. B.、Pham Chung T. T.、Nguyen Lam V.、Ta Tuan A.、Khu Dung T. K.、Agoh Masanobu、Pham An N.、Koike Satoshi、Ichimura Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 159-159

    • DOI

      10.1038/s41598-019-56703-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extremely diversified haplotypes observed among assemblage B population of Giardia intestinalis in Kenya.2020

    • Author(s)
      Tetsushi Mizuno, Elizabeth J. Matey, Xiuqiong Bi, Hiroshi Ichimura, Masaharu Tokoro.
    • Journal Title

      Parasitology International

      Volume: 75 Pages: 102038-102038

    • DOI

      10.1016/j.parint.2019.102038

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low concordance of oral and genital HPV infection among male patients with sexually transmitted infections in Vietnam2019

    • Author(s)
      Le HHL, Bi X, Ishizaki A, Le HV, Trung Vu Nguyen TV, Ichimura H
    • Journal Title

      BMC Infect Dis

      Volume: 19 Issue: 1 Pages: 578-578

    • DOI

      10.1186/s12879-019-4175-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Impact of antiretroviral therapy on the immune status of HIV-infected children.2018

    • Author(s)
      Xiuqiong Bi, Azumi Ishizaki, Thanh Binh Nguyen, Duyen Thi Nguyen, Hanh Phuong Nguyen, Lam Van Nguyen, Hung Viet Pham, Chung Thi Thu Phan, Thuy Thi Bich Phung, An Nhat Pham, Dung Thi Khanh Khu, Hiroshi Ichimura
    • Organizer
      1.22nd International AIDS Conference.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of antiretroviral therapy on the immune status of HIV-infected children.2018

    • Author(s)
      Xiuqiong Bi, Azumi Ishizaki, Thanh Binh Nguyen, Duyen Thi Nguyen, Hanh Phuong Nguyen, Lam Van Nguyen, Hung Viet Pham, Chung Thi Thu Phan, Thuy Thi Bich Phung, An Nhat Pham, Dung Thi Khanh Khu, Hiroshi Ichimura
    • Organizer
      2.第32回日本エイズ学会学術集会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 抗HIV療法が小児免疫状態に及ぼす影響2017

    • Author(s)
      畢 袖晴
    • Organizer
      日本エイズ学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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