| Project/Area Number |
17K10100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa University |
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Principal Investigator |
BI Xiuqiong 金沢大学, 医学系, 助教 (50565413)
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| Co-Investigator(Kenkyū-buntansha) |
市村 宏 金沢大学, 医学系, 教授 (10264756)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | HIV / ART / 小児 / 免疫状態 / HIV感染 / 抗HIV療法 / 免疫 |
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| Outline of Final Research Achievements |
This study investigated the impact of ART on the immune status of HIV-infected Vietnamese children. The differentiation of CD4 and CD8 cells, Th1/Th2/Th17/Treg subsets, and CD8 T cell activation were analyzed twice a year and compared to those of HIV-uninfected children.
After ART initiation, the CD4 cell counts including the CD4-RTE (recent thymic emigrants)/-naive/-cm (central memory)/-em (effector memory) and Th1 subsets, and the CD8-naive/-cm subset counts significantly increased and reached the HIV(─) children’s range by 6 months. The CD4-emra (emCD45RA+) and Th2/Th17/Treg, the activated CD8 cells, the CD8-em/-emra subsets, the CD4/CD8 ratio normalized within 4 years. The younger children showed better increase of CD4 counts at 6 months of ART. ART induced an early recovery of thymic function in HIV-infected children and lead to the early recovery of CD4 and CD8 naive subsets. Early diagnose of HIV infection followed by early ART is important for HIV administration in children.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、ベトナムの小児において、HIV感染小児の免疫状態が生後1-2か月から胸腺機能を含む異常状態になっていたことが示された。また、ART開始後、胸腺機能は６ヶ月までに回復し、CD4とCD8のnaive サブセットとTh1も早期に回復したが、他のCD4とCD8細胞のサブセットとCD8 T細胞の活性化の正常化は1-4年の治療が必要であった。更に、ART開始前の年齢は小さく、CD4細胞数が高いほどART開始後6ヶ月のCD4細胞増加数が多く、回復がよかった。小児において、HIV感染の早期診断、そしてARTの早期導入がHIV感染管理に重要である。
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