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Development of disease-specific therapy based on polycystic kidney disease pathophysiology focusing on lipid mediators

Research Project

Project/Area Number 17K10150
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Nakanishi Koichi  琉球大学, 医学(系)研究科(研究院), 教授 (50336880)

Co-Investigator(Kenkyū-buntansha) 島 友子  和歌山県立医科大学, 医学部, 講師 (60433364)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords多発性嚢胞腎 / 上皮間葉移行 / 増殖 / 分泌 / 細胞外基質 / 脂質メディエーター / miRNA
Outline of Final Research Achievements

The purpose of this study is to elucidate the involvement and mechanism of lipid mediators in multiple fundamental pathophysiology of polycystic kidney disease, and to provide a basis for the development of disease-specific therapy based on pathophysiology using modification of them, as well as confirming the effect by therapeutic research using model animals for its application to humans.
As a continuation of the previous research on PKD, we examined the involvement of miRNAs and lipid mediators, obtained data suggesting that several miRNAs, including miR-23a, are involved in the pathology of PKD, and further research are planning.

Academic Significance and Societal Importance of the Research Achievements

多発性嚢胞腎の複数の基本的病態生理における脂質メディエーターの関与とその機序が解明され、それらを修飾することによる病態生理に基づいた疾患特異的治療開発のための基礎的知見が獲得され、そのヒトへの応用のためのモデル動物を用いた治療研究による効果が確認されれば、新しい治療法の開発に繋がる可能性があり、医学・医療に貢献する。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2019 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] ARPKD2019

    • Author(s)
      中西浩一
    • Journal Title

      腎と透析

      Volume: 87 Pages: 744-748

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADPKDの最近の知見2019

    • Author(s)
      中西浩一
    • Journal Title

      日本腎臓学会誌

      Volume: 61 Pages: 1098-1101

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease2017

    • Author(s)
      Hama Taketsugu、Nakanishi Koichi、Sato Masashi、Mukaiyama Hironobu、Togawa Hiroko、Shima Yuko、Miyajima Masayasu、Nozu Kandai、Nagao Shizuko、Takahashi Hisahide、Sako Mayumi、Iijima Kazumoto、Yoshikawa Norishige、Suzuki Hiroyuki
    • Journal Title

      American Journal of Physiology-Renal Physiology

      Volume: 313 Issue: 6 Pages: F1223-F1231

    • DOI

      10.1152/ajprenal.00697.2016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 常染色体劣性多発性嚢胞腎(ARPKD)2019

    • Author(s)
      中西浩一
    • Organizer
      日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 遺伝学的に診断できた常染色体劣勢多発性嚢胞腎の遺伝型と臨床像2019

    • Author(s)
      森貞直哉,野津寛大,中西浩一,飯島一誠
    • Organizer
      発達腎研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 遺伝学的に診断できた常染色体劣勢多発性嚢胞腎の遺伝型と臨床像2019

    • Author(s)
      森貞直哉,野津寛大,中西浩一,飯島一誠
    • Organizer
      嚢胞性腎疾患研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Concurrent Session 2.2 Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): Outcome of CAKUT.2017

    • Author(s)
      Koichi Nakanishi
    • Organizer
      13th Asian Congress of Pediatric Nephrology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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