• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

risk factors of the subsequent chronic kidney disease in very low birth weight infants

Research Project

Project/Area Number 17K10160
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionNagoya City University (2018-2020)
The Japanese Red Cross Toyota College of Nursing (2017)

Principal Investigator

Uemura Osamu  名古屋市立大学, 医薬学総合研究院(医学), 研究員 (10511644)

Co-Investigator(Kenkyū-buntansha) 本田 雅敬  東京都立小児総合医療センター(臨床研究部), なし, アドバイザー (00129652)
石倉 健司  国立研究開発法人国立成育医療研究センター, 器官病態系内科部, 医長 (30276307)
金子 徹治  帝京大学, 公私立大学の部局等, 特別専門員 (30639084)
平野 大志  東京慈恵会医科大学, 医学部, 講師 (90424663)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords極低出生体重 / 子宮内発育遅延 / 新生児期ストレス / 慢性腎臓病 / 糸球体濾過量推算式 / 新生児急性腎不全 / 晩期循環不全 / 妊婦指導 / 極低出生体重児 / リスクファクター / 子宮内胎児発育遅延 / ダイエット / 喫煙 / 周産期 / 疫学調査 / 子宮内栄養不良 / 医療・福祉 / 臨床
Outline of Final Research Achievements

Chronic kidney disease (CKD) in young adults is linked to preterm birth and intrauterine growth restriction (IUGR). Which bring a higher risk of progression to chronic kidney damage in children with very low birth weight (VLBW), prematurity, IUGR, or stress during the neonatal period? This is the nationally historical cohort study in children with VLBW cared for in perinatal medical centers in Japan. The primary endpoint was estimated glomerular filtration rate (eGFR) at age over 3.0 years. A structural equation model was used to examine the pathologic constitution.
The 446 children with VLBW included 253 boys and 193 girls, of mean age 5.8 ± 2.6 years at last encounter. Pathway analyses showed that intrauterine malnutrition contributed more to chronic kidney damage than stress during the neonatal period > prematurity. This emphasizes the need for obstetricians to monitor for fetal growth restriction and neonatologists to minimize neonatal stress to prevent CKD in later life.

Academic Significance and Societal Importance of the Research Achievements

今回の研究で,極低出生体重の小児が慢性腎臓病となることに対して,子宮内発育遅延(IUGR)>>早産>新生児期のストレスの順で重要な危険因子であることが判明した。また新生児期のストレスでは,急性腎不全や晩期循環不全が重要な因子であることも分かった.
産科医は妊娠中の過度なダイエットなどによる胎児の成長制限を監視して妊婦の指導を行い、また出生後は新生児科医が新生児のストレスを最小限に抑えること(特に急性腎不全や晩期循環不全の予防や治療)がVLBWの腎予後に重要であると考える.

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (19 results)

All 2020 2019 2018 2017

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 4 results) Book (3 results)

  • [Journal Article] Perinatal factors contributing to chronic kidney disease in a cohort of Japanese children with very low birth weight2020

    • Author(s)
      Uemura Osamu、Ishikura Kenji、Kaneko Tetsuji、Hirano Daishi、Hamasaki Yuko、Ogura Masao、Mikami Naoaki、Gotoh Yoshimitsu、Sahashi Takeshi、Fujita Naoya、Yamamoto Masaki、Hibino Satoshi、Nakano Masaru、Wakano Yasuhiro、Honda Masataka
    • Journal Title

      Pediatric Nephrology

      Volume: 36 Issue: 4 Pages: 953-960

    • DOI

      10.1007/s00467-020-04791-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kidney function of Japanese children undergoing kidney transplant with preemptive therapy for cytomegalovirus infection2020

    • Author(s)
      Gotoh Yoshimitsu、Shishido Seiichiro、Hamasaki Yuko、Watarai Yoshihiko、Hattori Motoshi、Miura Kenichiro、Ishizuka Kiyonobu、Fujita Naoya、Saito Kazuhide、Nakagawa Yuki、Hotta Kiyohiko、Hataya Hiroshi、Hamada Riku、Sato Hiroyuki、Kitayama Hirotsugu、Ishikura Kenji、Honda Masataka、Uemura Osamu
    • Journal Title

      Transplant Infectious Disease

      Volume: Feb 28 Issue: 3

    • DOI

      10.1111/tid.13271

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Solute Clearance and Fluid Removal: Large-Dose Cyclic Tidal Peritoneal Dialysis.2019

    • Author(s)
      Hibino S, Uemura O, Uchida H, Majima H, Yamaguchi R, Tanaka K, Kawaguchi A, Yamakawa S, Fujita N.
    • Journal Title

      Ther Apher Dial

      Volume: 23 Issue: 2 Pages: 180-186

    • DOI

      10.1111/1744-9987.12765

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Steroid- and immunosuppressant-based protocol of Henoch-Schönlein purpura nephritis without angiotensin inhibitors in the acute phase: case series with correlation to histology.2018

    • Author(s)
      Kasahara K, Gotoh Y, Kuroyanagi Y, Nagano C, Yamakawa S, Tanaka K, Takeda A, Uemura O.
    • Journal Title

      Minerva Pediatr

      Volume: 71

    • DOI

      10.23736/s0026-4946.18.05324-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Children's Perceived Competence Scale: reevaluation in a population of Japanese elementary and junior high school students.2018

    • Author(s)
      Nagai Y, Nomura K, Nagata M, Kaneko T, Uemura O.
    • Journal Title

      Child Adolesc Psychiatry Ment Health

      Volume: 12 Issue: 1

    • DOI

      10.1186/s13034-018-0241-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood2018

    • Author(s)
      Kubota Wataru、Honda Masataka、Okada Hirokazu、Hattori Motoshi、Iwano Masayuki、Akioka Yuko、Ashida Akira、Kawasaki Yukihiko、Kiyomoto Hideyasu、Sako Mayumi、Terada Yoshio、Hirano Daishi、Fujieda Mikiya、et al.
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22 Issue: 4 Pages: 743-751

    • DOI

      10.1007/s10157-018-1589-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Down syndrome and mild kidney dysfunction.2018

    • Author(s)
      Yamakawa S, Nagai T, Uemura O.
    • Journal Title

      Pediatr Int

      Volume: 60 Issue: 4 Pages: 391-393

    • DOI

      10.1111/ped.13525

    • Related Report
      2018 Research-status Report
  • [Journal Article] Influence of thyroid function on glomerular filtration rate and other estimates of kidney function in two pediatric patients2018

    • Author(s)
      Uemura Osamu、Iwata Naoyuki、Nagai Takuhito、Yamakawa Satoshi、Hibino Satoshi、Yamamoto Masaki、Nakano Masaru、Tanaka Kazuki
    • Journal Title

      CEN Case Reports

      Volume: 7 Issue: 1 Pages: 169-173

    • DOI

      10.1007/s13730-018-0320-7

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of estimated glomerular filtration rate equations for Japanese children.2018

    • Author(s)
      Gotoh Y, Uemura O, Ishikura K, Sakai T, Hamasaki Y, Araki Y, Hamda R, Honda M
    • Journal Title

      Clin Exp Nephrol

      Volume: 22 Issue: 4 Pages: 931-937

    • DOI

      10.1007/s10157-018-1529-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Creatinine-based estimated glomerular filtration rate for children younger than 2?years2017

    • Author(s)
      Uemura Osamu、Ishikura Kenji、Gotoh Yoshimitsu、Honda Masataka
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22 Issue: 2 Pages: 483-484

    • DOI

      10.1007/s10157-017-1460-3

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Erratum to: Assessment of kidney function in children by enzymatic determination of 2-h or 24-h creatinine clearance: comparison with inulin clearance2017

    • Author(s)
      Uemura Osamu、Nagai Takuhito、Yamakawa Satoshi、Kaneko Tetsuji、Hibi Yoshiko、Yamasaki Yasuhito、Yamamoto Masaki、Nakano Masaru、Iwata Naoyuki、Hibino Satoshi
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 21 Issue: 6 Pages: 1141-1141

    • DOI

      10.1007/s10157-017-1445-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severe Glomerular Endothelial Injury Associated with a Short D4Z4 Repeat on Chromosome 4q352017

    • Author(s)
      Hibino Satoshi、Takeda Asami、Nishino Ichizo、Iwata Naoyuki、Nakano Masaru、Tanaka Kazuki、Yamakawa Satoshi、Nagai Takuhito、Uemura Osamu
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 14 Pages: 1849-1853

    • DOI

      10.2169/internalmedicine.56.7441

    • NAID

      130005773832

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness and nephrotoxicity of a 2-year medium dose of cyclosporine in pediatric patients with steroid-dependent nephrotic syndrome: determination of the need for follow-up kidney biopsy2017

    • Author(s)
      Kuroyanagi Yoshiyuki、Gotoh Yoshimitsu、Kasahara Katsuaki、Nagano China、Fujita Naoya、Yamakawa Satoshi、Yamamoto Masaki、Takeda Asami、Uemura Osamu
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 22 Issue: 2 Pages: 413-419

    • DOI

      10.1007/s10157-017-1444-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Performance in adolescents of the two Japanese serum creatinine based estimated glomerular filtration rate equations, for adults and paediatric patients: A study of the Japan Renal Biopsy Registry and Japan Kidney Disease Registry from 2007 to 20132017

    • Author(s)
      Uemura Osamu、Yokoyama Hitoshi、Ishikura Kenji、Gotoh Yoshimitsu、Sato Hiroshi、Sugiyama Hitoshi、Honda Masataka、Matsuo Seiichi
    • Journal Title

      Nephrology

      Volume: 22 Issue: 6 Pages: 494-497

    • DOI

      10.1111/nep.12982

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of tandem mass spectrometry-based creatinine measurement using dried blood spot for newborn mass screening2017

    • Author(s)
      Nakano Masaru、Uemura Osamu、Honda Masataka、Ito Tetsuya、Nakajima Yoko、Saitoh Shinji
    • Journal Title

      Pediatric Research

      Volume: 82 Issue: 2 Pages: 237-243

    • DOI

      10.1038/pr.2017.56

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pitfalls of diagnosing urinary tract infection in infants and young children2017

    • Author(s)
      Yamasaki Y, Uemura O, Nagai T, Yamakawa S, Hibi Y, Yamamoto M, Nakano M, Kasahara K, Bo Zhang.
    • Journal Title

      Pediatr Int

      Volume: 59 Issue: 7 Pages: 786-792

    • DOI

      10.1111/ped.13292

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Book] 小児臨床看護各論 小児看護学②2020

    • Author(s)
      上村治,吉野薫
    • Total Pages
      24
    • Publisher
      医学書院
    • ISBN
      9784260038669
    • Related Report
      2019 Research-status Report
  • [Book] 小児臨床看護各論 小児看護学②2018

    • Author(s)
      上村治,吉野薫.
    • Publisher
      医学書院
    • ISBN
      9784260019903
    • Related Report
      2018 Research-status Report
  • [Book] 小児腎臓病学 改訂第2版2017

    • Author(s)
      日本小児腎臓病学会
    • Total Pages
      434
    • Publisher
      診断と治療者
    • ISBN
      9784787823007
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi