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Effects of a novel antimicrobial peptide, AMP-IBP5, on wound healing

Research Project

Project/Area Number 17K10254
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionJuntendo University

Principal Investigator

Niyonsaba Francois  順天堂大学, 国際教養学部, 教授 (60365640)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords抗菌ペプチド / 糖尿病性潰瘍 / 創傷治癒 / 皮膚再生 / ケラチノサイト / 線維芽細胞 / 皮膚感染症 / 繊維芽細胞 / 血管新生 / マスト細胞 / 炎症反応 / アレルギー反応 / 再生医療
Outline of Final Research Achievements

AMP-IBP5 is a novel skin-derived antimicrobial peptide. Although the antimicrobial activities of AMP-IBP5 have been reported, its immunomodulatory functions remain unclear. To identify the wound healing properties AMP-IBP5, we evaluated its effect on angiogenesis and wound healing using human keratinocytes, fibroblasts and mast cells. We found AMP-IBP5 activated keratinocytes and mast cells via the MrgX1 to X4 receptors, while this peptide accelerated wound healing by promoting fibroblast activation through the LRP1 receptor. In addition, AMP-IBP5 promoted wound healing in both normal and diabetic mice, and this effect involved EGFR receptor and STAT pathways as evidenced by the inhibition of these pathways and the ability of AMP-IBP5 to induce phosphorylation of EGFR and STATs.

Academic Significance and Societal Importance of the Research Achievements

厚生労働省の調査によれば、2016年時点で糖尿病が疑われる成人の推計100万人を突破した。糖尿病にかかる年間医療費は1兆239億円であり、経済にも大きな負担となる。本研究の意義は、創傷治癒の難治化の主な要因は感染や血流低下であることから、AMP-IBP5の作用により、感染の抑制および血管新生の促進による血流の回復が達成され、極めて有効な慢性皮膚創傷の治癒促進薬の開発に貢献できると考える。AMP-IBP5が糖尿病性潰瘍の血管新生と創傷治癒を促進することによって、皮膚再生および恒常性に関与する新たな可能性を示す点であり、さらに感染症や創傷などの疾患の治療法へ用できることが期待される。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (60 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (19 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 18 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (38 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results) Book (3 results)

  • [Journal Article] Antimicrobial peptide derived from insulin‐like growth factor‐binding protein 5 improves diabetic wound healing2022

    • Author(s)
      Yue Hainan、Song Pu、Sutthammikorn Nutda、Umehara Yoshie、Trujillo‐Paez Juan Valentin、Nguyen Hai Le Thanh、Takahashi Miho、Peng Ge、Ikutama Risa、Okumura Ko、Ogawa Hideoki、Ikeda Shigaku、Niyonsaba Fran?ois
    • Journal Title

      Wound Repair and Regeneration

      Volume: 30 Issue: 2 Pages: 232-244

    • DOI

      10.1111/wrr.12997

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exogenous factors in the pathogenesis of atopic dermatitis: Irritants and cutaneous infections2021

    • Author(s)
      Yue Hainan、Umehara Yoshie、Trujillo‐Paez Juan Valentin、Peng Ge、Nguyen Hai Le Thanh、Chieosilapatham Panjit、Kiatsurayanon Chanisa、Song Pu、Okumura Ko、Ogawa Hideoki、Ikeda Shigaku、Niyonsaba Francois
    • Journal Title

      Clinical & Experimental Allergy

      Volume: 51 Issue: 3 Pages: 382-392

    • DOI

      10.1111/cea.13820

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Keratinocytes: innate immune cells in atopic dermatitis2021

    • Author(s)
      Chieosilapatham P.、Kiatsurayanon C.、Umehara Y.、Trujillo‐Paez J. V.、Peng G.、Yue H.、Nguyen L. T. H.、Niyonsaba F.
    • Journal Title

      Clinical & Experimental Immunology

      Volume: In press Issue: 3 Pages: 296-309

    • DOI

      10.1111/cei.13575

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intractable Itch in Atopic Dermatitis: Causes and Treatments2021

    • Author(s)
      Umehara Yoshie、Kiatsurayanon Chanisa、Trujillo-Paez Juan Valentin、Chieosilapatham Panjit、Peng Ge、Yue Hainan、Nguyen Hai Le Thanh、Song Pu、Okumura Ko、Ogawa Hideoki、Niyonsaba Francois
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 3 Pages: 229-229

    • DOI

      10.3390/biomedicines9030229

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts2020

    • Author(s)
      Chieosilapatham Panjit、Yue Hainan、Ikeda Shigaku、Ogawa Hideoki、Niyonsaba Francois
    • Journal Title

      Journal of Dermatological Science

      Volume: 99 Issue: 3 Pages: 158-167

    • DOI

      10.1016/j.jdermsci.2020.07.003

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis2020

    • Author(s)
      Nguyen Hai Le Thanh、Trujillo-Paez Juan Valentin、Umehara Yoshie、Yue Hainan、Peng Ge、Kiatsurayanon Chanisa、Chieosilapatham Panjit、Song Pu、Okumura Ko、Ogawa Hideoki、Ikeda Shigaku、Niyonsaba Francois
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 20 Pages: 7607-7607

    • DOI

      10.3390/ijms21207607

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells2020

    • Author(s)
      Umehara Yoshie、Toyama Sumika、Tominaga Mitsutoshi、Matsuda Hironori、Takahashi Nobuaki、Kamata Yayoi、Niyonsaba Francois、Ogawa Hideoki、Takamori Kenji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 4360-4360

    • DOI

      10.1038/s41598-020-60036-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antimicrobial peptide derived from insulin‐like growth factor‐binding protein 5 activates mast cells via Mas‐related G protein‐coupled receptor X22019

    • Author(s)
      Niyonsaba Francois、Song Pu、Yue Hainan、Sutthammikorn Nutda、Umehara Yoshie、Okumura Ko、Ogawa Hideoki
    • Journal Title

      Allergy

      Volume: 75 Issue: 1 Pages: 203-207

    • DOI

      10.1111/all.13975

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 activates mast cells via Mas-related G protein-coupled receptor X22019

    • Author(s)
      Niyonsaba F, Song P, Yue H, Sutthammikorn N, Umehara Y, Okumura K, ,Ogawa H
    • Journal Title

      Allergy

      Volume: -

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Correction: Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines2018

    • Author(s)
      Sekihara Kazumasa、Saitoh Kaori、Yang Haeun、Kawashima Haruki、Kazuno Saiko、Kikkawa Mika、Arai Hajime、Miida Takashi、Hayashi Nobuhiro、Niyonsaba Francois、Sasai Keisuke、Tabe Yoko
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 10 Pages: 1-1

    • DOI

      10.1371/journal.pone.0205581

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MrgX2-mediated internalization of LL-37 and degranulation of human LAD2 mast cells.2018

    • Author(s)
      Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I.
    • Journal Title

      Molecular Medicine Reports

      Volume: 18 Pages: 4951-4959

    • DOI

      10.3892/mmr.2018.9532

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tissue-specific Regulation of Innate Immune Responses by Human Cathelicidin LL-372018

    • Author(s)
      Chieosilapatham Panjit、Ikeda Shigaku、Ogawa Hideoki、Niyonsaba Francois
    • Journal Title

      Current Pharmaceutical Design

      Volume: 24 Issue: 10 Pages: 1079-1091

    • DOI

      10.2174/1381612824666180327113418

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Role of Host Defense Peptide Human β-defensins in the Maintenance of Skin Barriers2018

    • Author(s)
      Kiatsurayanon Chanisa、Ogawa Hideoki、Niyonsaba Francois
    • Journal Title

      Current Pharmaceutical Design

      Volume: 24 Issue: 10 Pages: 1092-1099

    • DOI

      10.2174/1381612824666180327164445

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors2017

    • Author(s)
      Chieosilapatham Panjit、Niyonsaba Francois、Kiatsurayanon Chanisa、Okumura Ko、Ikeda Shigaku、Ogawa Hideoki
    • Journal Title

      Journal of Dermatological Science

      Volume: 88 Issue: 1 Pages: 117-125

    • DOI

      10.1016/j.jdermsci.2017.05.008

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases.2017

    • Author(s)
      Niyonsaba F, Kiatsurayanon C, Chieosilapatham P, Ogawa H
    • Journal Title

      Experimental Dermatology

      Volume: - Issue: 11 Pages: 989-998

    • DOI

      10.1111/exd.13314

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-?B-sensitive pathways2017

    • Author(s)
      Yanashima Kensuke、Chieosilapatham Panjit、Yoshimoto Eri、Okumura Ko、Ogawa Hideoki、Niyonsaba Francois
    • Journal Title

      Immunologic Research

      Volume: 65 Issue: 4 Pages: 920-931

    • DOI

      10.1007/s12026-017-8932-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Current insights into the role of human β-defensins in atopic dermatitis2017

    • Author(s)
      Chieosilapatham P.、Ogawa H.、Niyonsaba F.
    • Journal Title

      Clinical & Experimental Immunology

      Volume: 190 Issue: 2 Pages: 155-166

    • DOI

      10.1111/cei.13013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antimicrobial peptides human LL-37 and β-defensin-3 modulate the expression of nerve elongation factors in human epidermal keratinocytes2017

    • Author(s)
      Umehara Yoshie、Kamata Yayoi、Tominaga Mitsutoshi、Niyonsaba Fran?ois、Ogawa Hideoki、Takamori Kenji
    • Journal Title

      Journal of Dermatological Science

      Volume: 88 Issue: 3 Pages: 365-367

    • DOI

      10.1016/j.jdermsci.2017.07.010

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 抗菌ペプチドと皮膚疾患2017

    • Author(s)
      ニヨンサバ フランソワ
    • Journal Title

      Bio Industry

      Volume: 34 Pages: 44-52

    • Related Report
      2017 Research-status Report
  • [Presentation] Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 promotes diabetic wound healing by rescuing high-glucose-mediated dysfunction of keratinocytes. The 30th Korean Society for Investigative Dermatology Annual Meeting.2022

    • Author(s)
      Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen LTH, Takahashi M, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      The 30th Korean Society for Investigative Dermatology Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AMP-IBP5 improves diabetic wound healing via activation of EGFR/STAT pathways. 第120回日本皮膚科学会総会2021

    • Author(s)
      Yue H, Umehara Y, Peng G, Nguyen LTH, Takahashi M, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F.
    • Organizer
      第120回日本皮膚科学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] AMP-IBP5, an antimicrobial peptide derived from insulin-like growth factor-binding protein 5, promotes diabetic wound healing. The 46th Annual Meeting of the Japanese Society for Investigative Dermatology2021

    • Author(s)
      Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen LTH, Takahashi M, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2021 Annual Research Report
  • [Presentation] The antimicrobial peptide human beta-defensin-3 activates autophagy in human keratinocytes.2020

    • Author(s)
      Peng G, Kageyama S, Ikutama R, Umehara Y, Trujillo Paez JV, Nguyen HL, Takahashi M, Yue H, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F.
    • Organizer
      The 78th Annual Meeting of the Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] マスト細胞のメラトニン生合成酵素の上昇第2020

    • Author(s)
      西 晴久, ニヨンサバ フランソワ
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2020 Research-status Report 2019 Research-status Report
  • [Presentation] Tight junction barrier regulation by calcitriol and LL-37 in diabetes2020

    • Author(s)
      Trujillo V, Umehara Y, Okumura K, Ogawa H, Niyonsaba F
    • Organizer
      第119回日本皮膚科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Acceleration of diabetic wound healing by an antimicrobial peptide AMP-IBP52020

    • Author(s)
      Yue H, Umehara Y, Trujillo V, Okumura K, Ikeda S, Ogawa H, Niyonsaba F
    • Organizer
      第119回日本皮膚科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effect of the antimicrobial peptide AMP-IBP5 on skin barrier regulation2020

    • Author(s)
      Nguyen LTH, Trujillo V, Peng G, Yue H, Ikutama R, Takahashi M, Umehara Y, Ikeda S, Ogawa H, Niyonsaba F
    • Organizer
      第119回日本皮膚科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effect of human beta-defensin-3 on in vivo wound healing2020

    • Author(s)
      Takahashi M, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      第119回日本皮膚科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Human beta-defensin-3 activates autophagy linked to tight junction barrier in keratinocytes2020

    • Author(s)
      Peng G, Kageyama S, Ikutama R, Umehara Y, Trujillo Paez JV, Nguyen HL, Yue H, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      第119回日本皮膚科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] . 表皮角化細胞におけるLL-37とオートファジーの関係2020

    • Author(s)
      生玉梨紗, 彭 戈, 梅原芳恵, 奥村 康, 小川 秀興, 池田 志斈, ニヨンサバ フランソワ
    • Organizer
      第119回日本皮膚科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] The lipoprotein receptor LRP1 is required for AMP-IBP5-induced migration and proliferation of keratinocytes and fibroblasts2020

    • Author(s)
      Niyonsaba F, Chieosilapatham P, Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Takahashi M, Ikutama R, Okumura K, Ikeda S, Ogawa H
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
  • [Presentation] Calcitriol improves the symptoms of atopic dermatitis mice2020

    • Author(s)
      Umehara Y, Trujillo-Paez JV, Peng G, Tominaga M, Yue H, Nguyen HLT, Ikutama R, Takahashi M, Takamori K, Okumura K, Ogawa H. Niyonsaba F
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
  • [Presentation] Effect of hBD-3 on Th2 cytokine-mediated modulation of autophagy in human keratinocytes2020

    • Author(s)
      Peng G, Ikutama R, Umehara Y, Trujillo V, Yue H, Nguyen HL, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
  • [Presentation] Relationship of human cathelicidin LL-37 and autophagy in human keratinocytes2020

    • Author(s)
      Ikutama R, Peng G, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
  • [Presentation] The effect of antimicrobial peptide AMP-IBP5 on skin barrier regulation.2020

    • Author(s)
      Nguyen HLT, Trujillo-Paez JV, Peng G, Yue H, Ikutama R, Takahashi M, Umehara Y, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
  • [Presentation] Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing via MAPK pathways.2020

    • Author(s)
      Yue H, Umehara Y, Trujillo V, Nguyen HL, Peng G, Takahashi M, Ikutama R, Okumura K, Ikeda S, Ogawa H, Niyonsaba F
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
  • [Presentation] Effect of human b-defensins-3 on wound healing2020

    • Author(s)
      Takahashi M, Umehara Y, Yue H, Trujillo Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ikeda S, Ogawa H, Niyonsaba F
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
  • [Presentation] Regulation of skin-tight junction barrier function by calcitriol in diabetic milieu2020

    • Author(s)
      Trujillo V, Nguyen HL, Umehara Y, Yue H, Ikutama R, Takahashi M, Peng G, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
  • [Presentation] Both human β-defensin-3 and autophagy are needed for maintenance of the skin barrier. 第50回日本皮膚免疫アレルギー学会総会学術大会2020

    • Author(s)
      Peng G, Ikutama R, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      第50回日本皮膚免疫アレルギー学会総会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] The effect of antimicrobial peptide AMP-IBP5 on skin barrier regulation2020

    • Author(s)
      Nguyen HL, Trujillo V, Peng G, Yue H, Ikutama R, Takahashi M, Umehara Y, Ogawa H, Ikeda S, Niyonsaba F
    • Organizer
      第50回日本皮膚免疫アレルギー学会総会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 抗菌ペプチドAMP-IBP5がMrgprX2受容体を媒介してマスト細胞を活性化させる2020

    • Author(s)
      ニヨンサバ フランソワ, 岳 海楠, 梅原 芳恵, 生玉 梨紗, 髙橋 美帆, 奥村 康, 池田 志斈, 小川 秀興
    • Organizer
      第50回日本皮膚免疫アレルギー学会総会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Gynura procumbens directly stimulated fibroblast, keratinocyte, endothelial cell and mast cell, the predominant cells in wound healing mechanism.2019

    • Author(s)
      Sutthammikorn N, Supajatura V, Nakano N, Niyonsaba F, Ogawa H
    • Organizer
      4th International Conference on One Medicine One Science
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of Gynura procumbens on proliferation and migration of fibroblast and keratinocyte, and production of cytokine associated with wound healing2019

    • Author(s)
      Sutthammikorn N, Supajatura V, Niyonsaba F, Ogawa H
    • Organizer
      Phayao Research Conference 8
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Effects of AMP-IBP5, an antimicrobial peptide derived from insulin-like growth factor-binding protein 5 on diabetic wound healing2019

    • Author(s)
      Yue H, Niyonsaba F, Umehara Y, Trujillo V, Okumura K, Ikeda S, Ogawa H.
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
  • [Presentation] Candidalysin, a virulence factor of Candida albicans, is involved in exacerbation of the imiquimod-induced psoriasis.2019

    • Author(s)
      Song P, Niyonsaba F, Umehara Y, Ogawa T, Ikeda S, Okumura K, Ogawa H.
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
  • [Presentation] Candidalysin mediates human mast cell activation through dectin-1 and MAPK pathways.2019

    • Author(s)
      Niyonsaba F, Song P, Umehara Y, Ogawa T, Ikeda S, Okumura K, Ogawa H.
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
  • [Presentation] Regulation of tight junctions and differentiation markers in keratinocytes by calcitriol in diabetes.2019

    • Author(s)
      Trujillo V, Umehara Y, Okumura K, Niyonsaba F.
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
  • [Presentation] Effects of antimicrobial peptide human β-defensin-3 on wound healing.2019

    • Author(s)
      Umehara Y, Sutthammikorn N, Song P, Yue H, Okumura K, Ogawa H, Niyonsaba F.
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
  • [Presentation] 宿主防御ペプチドであるIDR-1018 がマスト細胞に与える影響2018

    • Author(s)
      簗島健介, 奥村 康, 池田志斈, 小川秀興, ニヨンサバ フランソワ
    • Organizer
      第117回日本皮膚科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Candidalysin, a virulence factor of Candida albicans, activates human keratinocytes2018

    • Author(s)
      Song P, Niyonsaba F, Ogawa T, Okumura K, Ikeda S, Ogawa H
    • Organizer
      第32回表皮細胞研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Candidalysin, a virulence factor of Candida albicans, activates human keratinocytes through MAPK and NF-kB pathways2018

    • Author(s)
      Song P, Niyonsaba F, Okumura K, Ikeda S, Ogawa H.
    • Organizer
      International Investigative Dermatology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] AMP-IBP5, an antimicrobial peptide derived from insulin-like growth factor-binding protein 5, triggers human keratinocyte activation.2018

    • Author(s)
      28.Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H
    • Organizer
      International Investigative Dermatology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel antimicrobial (host defense) peptide AMP-IBP5 activates human keratinocytes2018

    • Author(s)
      29.Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H
    • Organizer
      5th Eastern Asia Dermatology Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A virulence factor of Candida albicans, Candidalysin, modulates human keratinocyte functions.2018

    • Author(s)
      30.Song P, Niyonsaba F, Okumura K, Ikeda S, Ogawa H
    • Organizer
      5th Eastern Asia Dermatology Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-kB-sensitive pathways2017

    • Author(s)
      Yanashima K, Chieosilapatham P, Okumura K, Ogawa H, Niyonsaba F
    • Organizer
      The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2017 Research-status Report
  • [Presentation] Synthetic host defense peptide IDR-1018 activates various functions of human mast cells2017

    • Author(s)
      Yanashima K, Chieosilapatham P, Okumura K, Ogawa H, Niyonsaba F
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Immunology
    • Related Report
      2017 Research-status Report
  • [Presentation] Enhancement of allergic degranulation via the P2Y receptor in mast cells2017

    • Author(s)
      Nishi H, Niyonsaba F
    • Organizer
      The 90th Annual Meeting of the Japanese Pharmacological Society
    • Related Report
      2017 Research-status Report
  • [Book] Comorbidities in atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment2020

    • Author(s)
      Kiatsurayanon C, Niyonsaba F
    • Total Pages
      265
    • Publisher
      Nova Science Publishers, New York
    • Related Report
      2020 Research-status Report
  • [Book] Emerging therapies for atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment2020

    • Author(s)
      Peng G, Niyonsaba F
    • Total Pages
      265
    • Publisher
      Nova Science Publishers, New York
    • Related Report
      2020 Research-status Report
  • [Book] 抗菌ペプチドの機能解明と技術利用2017

    • Author(s)
      ニヨンサバ フランソワ( 長岡 功 監修)
    • Publisher
      シーエムシー出版
    • ISBN
      9784781312453
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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