Effects of a novel antimicrobial peptide, AMP-IBP5, on wound healing

• Project/Area Number: 17K10254
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Juntendo University
• Principal Investigator: Niyonsaba Francois 順天堂大学, 国際教養学部, 教授 (60365640)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 抗菌ペプチド / 糖尿病性潰瘍 / 創傷治癒 / 皮膚再生 / ケラチノサイト / 線維芽細胞 / 皮膚感染症 / 繊維芽細胞 / 血管新生 / マスト細胞 / 炎症反応 / アレルギー反応 / 再生医療

Outline of Final Research Achievements

AMP-IBP5 is a novel skin-derived antimicrobial peptide. Although the antimicrobial activities of AMP-IBP5 have been reported, its immunomodulatory functions remain unclear. To identify the wound healing properties AMP-IBP5, we evaluated its effect on angiogenesis and wound healing using human keratinocytes, fibroblasts and mast cells. We found AMP-IBP5 activated keratinocytes and mast cells via the MrgX1 to X4 receptors, while this peptide accelerated wound healing by promoting fibroblast activation through the LRP1 receptor. In addition, AMP-IBP5 promoted wound healing in both normal and diabetic mice, and this effect involved EGFR receptor and STAT pathways as evidenced by the inhibition of these pathways and the ability of AMP-IBP5 to induce phosphorylation of EGFR and STATs.

Academic Significance and Societal Importance of the Research Achievements

厚生労働省の調査によれば、2016年時点で糖尿病が疑われる成人の推計100万人を突破した。糖尿病にかかる年間医療費は1兆239億円であり、経済にも大きな負担となる。本研究の意義は、創傷治癒の難治化の主な要因は感染や血流低下であることから、AMP-IBP5の作用により、感染の抑制および血管新生の促進による血流の回復が達成され、極めて有効な慢性皮膚創傷の治癒促進薬の開発に貢献できると考える。AMP-IBP5が糖尿病性潰瘍の血管新生と創傷治癒を促進することによって、皮膚再生および恒常性に関与する新たな可能性を示す点であり、さらに感染症や創傷などの疾患の治療法へ用できることが期待される。

Research Products

• [Journal Article] Antimicrobial peptide derived from insulin‐like growth factor‐binding protein 5 improves diabetic wound healing (2022)
  • Author(s): Yue Hainan、Song Pu、Sutthammikorn Nutda、Umehara Yoshie、Trujillo‐Paez Juan Valentin、Nguyen Hai Le Thanh、Takahashi Miho、Peng Ge、Ikutama Risa、Okumura Ko、Ogawa Hideoki、Ikeda Shigaku、Niyonsaba Fran?ois
  • Journal Title: Wound Repair and Regeneration Volume: 30 Issue: 2 Pages: 232-244
  • DOI: 10.1111/wrr.12997
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exogenous factors in the pathogenesis of atopic dermatitis: Irritants and cutaneous infections (2021)
  • Author(s): Yue Hainan、Umehara Yoshie、Trujillo‐Paez Juan Valentin、Peng Ge、Nguyen Hai Le Thanh、Chieosilapatham Panjit、Kiatsurayanon Chanisa、Song Pu、Okumura Ko、Ogawa Hideoki、Ikeda Shigaku、Niyonsaba Francois
  • Journal Title: Clinical & Experimental Allergy Volume: 51 Issue: 3 Pages: 382-392
  • DOI: 10.1111/cea.13820
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Keratinocytes: innate immune cells in atopic dermatitis (2021)
  • Author(s): Chieosilapatham P.、Kiatsurayanon C.、Umehara Y.、Trujillo‐Paez J. V.、Peng G.、Yue H.、Nguyen L. T. H.、Niyonsaba F.
  • Journal Title: Clinical & Experimental Immunology Volume: In press Issue: 3 Pages: 296-309
  • DOI: 10.1111/cei.13575
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intractable Itch in Atopic Dermatitis: Causes and Treatments (2021)
  • Author(s): Umehara Yoshie、Kiatsurayanon Chanisa、Trujillo-Paez Juan Valentin、Chieosilapatham Panjit、Peng Ge、Yue Hainan、Nguyen Hai Le Thanh、Song Pu、Okumura Ko、Ogawa Hideoki、Niyonsaba Francois
  • Journal Title: Biomedicines Volume: 9 Issue: 3 Pages: 229-229
  • DOI: 10.3390/biomedicines9030229
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts (2020)
  • Author(s): Chieosilapatham Panjit、Yue Hainan、Ikeda Shigaku、Ogawa Hideoki、Niyonsaba Francois
  • Journal Title: Journal of Dermatological Science Volume: 99 Issue: 3 Pages: 158-167
  • DOI: 10.1016/j.jdermsci.2020.07.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis (2020)
  • Author(s): Nguyen Hai Le Thanh、Trujillo-Paez Juan Valentin、Umehara Yoshie、Yue Hainan、Peng Ge、Kiatsurayanon Chanisa、Chieosilapatham Panjit、Song Pu、Okumura Ko、Ogawa Hideoki、Ikeda Shigaku、Niyonsaba Francois
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 20 Pages: 7607-7607
  • DOI: 10.3390/ijms21207607
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells (2020)
  • Author(s): Umehara Yoshie、Toyama Sumika、Tominaga Mitsutoshi、Matsuda Hironori、Takahashi Nobuaki、Kamata Yayoi、Niyonsaba Francois、Ogawa Hideoki、Takamori Kenji
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 4360-4360
  • DOI: 10.1038/s41598-020-60036-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antimicrobial peptide derived from insulin‐like growth factor‐binding protein 5 activates mast cells via Mas‐related G protein‐coupled receptor X2 (2019)
  • Author(s): Niyonsaba Francois、Song Pu、Yue Hainan、Sutthammikorn Nutda、Umehara Yoshie、Okumura Ko、Ogawa Hideoki
  • Journal Title: Allergy Volume: 75 Issue: 1 Pages: 203-207
  • DOI: 10.1111/all.13975
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 activates mast cells via Mas-related G protein-coupled receptor X2 (2019)
  • Author(s): Niyonsaba F, Song P, Yue H, Sutthammikorn N, Umehara Y, Okumura K, ,Ogawa H
  • Journal Title: Allergy Volume: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Correction: Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines (2018)
  • Author(s): Sekihara Kazumasa、Saitoh Kaori、Yang Haeun、Kawashima Haruki、Kazuno Saiko、Kikkawa Mika、Arai Hajime、Miida Takashi、Hayashi Nobuhiro、Niyonsaba Francois、Sasai Keisuke、Tabe Yoko
  • Journal Title: PLOS ONE Volume: 13 Issue: 10 Pages: 1-1
  • DOI: 10.1371/journal.pone.0205581
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MrgX2-mediated internalization of LL-37 and degranulation of human LAD2 mast cells. (2018)
  • Author(s): Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I.
  • Journal Title: Molecular Medicine Reports Volume: 18 Pages: 4951-4959
  • DOI: 10.3892/mmr.2018.9532
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tissue-specific Regulation of Innate Immune Responses by Human Cathelicidin LL-37 (2018)
  • Author(s): Chieosilapatham Panjit、Ikeda Shigaku、Ogawa Hideoki、Niyonsaba Francois
  • Journal Title: Current Pharmaceutical Design Volume: 24 Issue: 10 Pages: 1079-1091
  • DOI: 10.2174/1381612824666180327113418
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Role of Host Defense Peptide Human β-defensins in the Maintenance of Skin Barriers (2018)
  • Author(s): Kiatsurayanon Chanisa、Ogawa Hideoki、Niyonsaba Francois
  • Journal Title: Current Pharmaceutical Design Volume: 24 Issue: 10 Pages: 1092-1099
  • DOI: 10.2174/1381612824666180327164445
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors (2017)
  • Author(s): Chieosilapatham Panjit、Niyonsaba Francois、Kiatsurayanon Chanisa、Okumura Ko、Ikeda Shigaku、Ogawa Hideoki
  • Journal Title: Journal of Dermatological Science Volume: 88 Issue: 1 Pages: 117-125
  • DOI: 10.1016/j.jdermsci.2017.05.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases. (2017)
  • Author(s): Niyonsaba F, Kiatsurayanon C, Chieosilapatham P, Ogawa H
  • Journal Title: Experimental Dermatology Volume: - Issue: 11 Pages: 989-998
  • DOI: 10.1111/exd.13314
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-?B-sensitive pathways (2017)
  • Author(s): Yanashima Kensuke、Chieosilapatham Panjit、Yoshimoto Eri、Okumura Ko、Ogawa Hideoki、Niyonsaba Francois
  • Journal Title: Immunologic Research Volume: 65 Issue: 4 Pages: 920-931
  • DOI: 10.1007/s12026-017-8932-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Current insights into the role of human β-defensins in atopic dermatitis (2017)
  • Author(s): Chieosilapatham P.、Ogawa H.、Niyonsaba F.
  • Journal Title: Clinical & Experimental Immunology Volume: 190 Issue: 2 Pages: 155-166
  • DOI: 10.1111/cei.13013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antimicrobial peptides human LL-37 and β-defensin-3 modulate the expression of nerve elongation factors in human epidermal keratinocytes (2017)
  • Author(s): Umehara Yoshie、Kamata Yayoi、Tominaga Mitsutoshi、Niyonsaba Fran?ois、Ogawa Hideoki、Takamori Kenji
  • Journal Title: Journal of Dermatological Science Volume: 88 Issue: 3 Pages: 365-367
  • DOI: 10.1016/j.jdermsci.2017.07.010
  • Peer Reviewed
• [Journal Article] 抗菌ペプチドと皮膚疾患 (2017)
  • Author(s): ニヨンサバ フランソワ
  • Journal Title: Bio Industry Volume: 34 Pages: 44-52
• [Presentation] Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 promotes diabetic wound healing by rescuing high-glucose-mediated dysfunction of keratinocytes. The 30th Korean Society for Investigative Dermatology Annual Meeting. (2022)
  • Author(s): Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen LTH, Takahashi M, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: The 30th Korean Society for Investigative Dermatology Annual Meeting
  • Int'l Joint Research
• [Presentation] AMP-IBP5 improves diabetic wound healing via activation of EGFR/STAT pathways. 第120回日本皮膚科学会総会 (2021)
  • Author(s): Yue H, Umehara Y, Peng G, Nguyen LTH, Takahashi M, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F.
  • Organizer: 第120回日本皮膚科学会総会
• [Presentation] AMP-IBP5, an antimicrobial peptide derived from insulin-like growth factor-binding protein 5, promotes diabetic wound healing. The 46th Annual Meeting of the Japanese Society for Investigative Dermatology (2021)
  • Author(s): Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen LTH, Takahashi M, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] The antimicrobial peptide human beta-defensin-3 activates autophagy in human keratinocytes. (2020)
  • Author(s): Peng G, Kageyama S, Ikutama R, Umehara Y, Trujillo Paez JV, Nguyen HL, Takahashi M, Yue H, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F.
  • Organizer: The 78th Annual Meeting of the Society for Investigative Dermatology
  • Int'l Joint Research
• [Presentation] マスト細胞のメラトニン生合成酵素の上昇第 (2020)
  • Author(s): 西 晴久, ニヨンサバ フランソワ
  • Organizer: 第93回日本薬理学会年会
• [Presentation] Tight junction barrier regulation by calcitriol and LL-37 in diabetes (2020)
  • Author(s): Trujillo V, Umehara Y, Okumura K, Ogawa H, Niyonsaba F
  • Organizer: 第119回日本皮膚科学会総会
• [Presentation] Acceleration of diabetic wound healing by an antimicrobial peptide AMP-IBP5 (2020)
  • Author(s): Yue H, Umehara Y, Trujillo V, Okumura K, Ikeda S, Ogawa H, Niyonsaba F
  • Organizer: 第119回日本皮膚科学会総会
• [Presentation] Effect of the antimicrobial peptide AMP-IBP5 on skin barrier regulation (2020)
  • Author(s): Nguyen LTH, Trujillo V, Peng G, Yue H, Ikutama R, Takahashi M, Umehara Y, Ikeda S, Ogawa H, Niyonsaba F
  • Organizer: 第119回日本皮膚科学会総会
• [Presentation] Effect of human beta-defensin-3 on in vivo wound healing (2020)
  • Author(s): Takahashi M, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: 第119回日本皮膚科学会総会
• [Presentation] Human beta-defensin-3 activates autophagy linked to tight junction barrier in keratinocytes (2020)
  • Author(s): Peng G, Kageyama S, Ikutama R, Umehara Y, Trujillo Paez JV, Nguyen HL, Yue H, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: 第119回日本皮膚科学会総会
• [Presentation] . 表皮角化細胞におけるLL-37とオートファジーの関係 (2020)
  • Author(s): 生玉梨紗, 彭 戈, 梅原芳恵, 奥村 康, 小川 秀興, 池田 志斈, ニヨンサバ フランソワ
  • Organizer: 第119回日本皮膚科学会総会
• [Presentation] The lipoprotein receptor LRP1 is required for AMP-IBP5-induced migration and proliferation of keratinocytes and fibroblasts (2020)
  • Author(s): Niyonsaba F, Chieosilapatham P, Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Takahashi M, Ikutama R, Okumura K, Ikeda S, Ogawa H
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Calcitriol improves the symptoms of atopic dermatitis mice (2020)
  • Author(s): Umehara Y, Trujillo-Paez JV, Peng G, Tominaga M, Yue H, Nguyen HLT, Ikutama R, Takahashi M, Takamori K, Okumura K, Ogawa H. Niyonsaba F
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Effect of hBD-3 on Th2 cytokine-mediated modulation of autophagy in human keratinocytes (2020)
  • Author(s): Peng G, Ikutama R, Umehara Y, Trujillo V, Yue H, Nguyen HL, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Relationship of human cathelicidin LL-37 and autophagy in human keratinocytes (2020)
  • Author(s): Ikutama R, Peng G, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] The effect of antimicrobial peptide AMP-IBP5 on skin barrier regulation. (2020)
  • Author(s): Nguyen HLT, Trujillo-Paez JV, Peng G, Yue H, Ikutama R, Takahashi M, Umehara Y, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing via MAPK pathways. (2020)
  • Author(s): Yue H, Umehara Y, Trujillo V, Nguyen HL, Peng G, Takahashi M, Ikutama R, Okumura K, Ikeda S, Ogawa H, Niyonsaba F
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Effect of human b-defensins-3 on wound healing (2020)
  • Author(s): Takahashi M, Umehara Y, Yue H, Trujillo Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ikeda S, Ogawa H, Niyonsaba F
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Regulation of skin-tight junction barrier function by calcitriol in diabetic milieu (2020)
  • Author(s): Trujillo V, Nguyen HL, Umehara Y, Yue H, Ikutama R, Takahashi M, Peng G, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Both human β-defensin-3 and autophagy are needed for maintenance of the skin barrier. 第50回日本皮膚免疫アレルギー学会総会学術大会 (2020)
  • Author(s): Peng G, Ikutama R, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: 第50回日本皮膚免疫アレルギー学会総会学術大会
• [Presentation] The effect of antimicrobial peptide AMP-IBP5 on skin barrier regulation (2020)
  • Author(s): Nguyen HL, Trujillo V, Peng G, Yue H, Ikutama R, Takahashi M, Umehara Y, Ogawa H, Ikeda S, Niyonsaba F
  • Organizer: 第50回日本皮膚免疫アレルギー学会総会学術大会
• [Presentation] 抗菌ペプチドAMP-IBP5がMrgprX2受容体を媒介してマスト細胞を活性化させる (2020)
  • Author(s): ニヨンサバ フランソワ, 岳 海楠, 梅原 芳恵, 生玉 梨紗, 髙橋 美帆, 奥村 康, 池田 志斈, 小川 秀興
  • Organizer: 第50回日本皮膚免疫アレルギー学会総会学術大会
  • Invited
• [Presentation] Gynura procumbens directly stimulated fibroblast, keratinocyte, endothelial cell and mast cell, the predominant cells in wound healing mechanism. (2019)
  • Author(s): Sutthammikorn N, Supajatura V, Nakano N, Niyonsaba F, Ogawa H
  • Organizer: 4th International Conference on One Medicine One Science
  • Int'l Joint Research
• [Presentation] Effect of Gynura procumbens on proliferation and migration of fibroblast and keratinocyte, and production of cytokine associated with wound healing (2019)
  • Author(s): Sutthammikorn N, Supajatura V, Niyonsaba F, Ogawa H
  • Organizer: Phayao Research Conference 8
  • Invited
• [Presentation] Effects of AMP-IBP5, an antimicrobial peptide derived from insulin-like growth factor-binding protein 5 on diabetic wound healing (2019)
  • Author(s): Yue H, Niyonsaba F, Umehara Y, Trujillo V, Okumura K, Ikeda S, Ogawa H.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Candidalysin, a virulence factor of Candida albicans, is involved in exacerbation of the imiquimod-induced psoriasis. (2019)
  • Author(s): Song P, Niyonsaba F, Umehara Y, Ogawa T, Ikeda S, Okumura K, Ogawa H.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Candidalysin mediates human mast cell activation through dectin-1 and MAPK pathways. (2019)
  • Author(s): Niyonsaba F, Song P, Umehara Y, Ogawa T, Ikeda S, Okumura K, Ogawa H.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Regulation of tight junctions and differentiation markers in keratinocytes by calcitriol in diabetes. (2019)
  • Author(s): Trujillo V, Umehara Y, Okumura K, Niyonsaba F.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Effects of antimicrobial peptide human β-defensin-3 on wound healing. (2019)
  • Author(s): Umehara Y, Sutthammikorn N, Song P, Yue H, Okumura K, Ogawa H, Niyonsaba F.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] 宿主防御ペプチドであるIDR-1018 がマスト細胞に与える影響 (2018)
  • Author(s): 簗島健介, 奥村 康, 池田志斈, 小川秀興, ニヨンサバ フランソワ
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] Candidalysin, a virulence factor of Candida albicans, activates human keratinocytes (2018)
  • Author(s): Song P, Niyonsaba F, Ogawa T, Okumura K, Ikeda S, Ogawa H
  • Organizer: 第32回表皮細胞研究会
• [Presentation] Candidalysin, a virulence factor of Candida albicans, activates human keratinocytes through MAPK and NF-kB pathways (2018)
  • Author(s): Song P, Niyonsaba F, Okumura K, Ikeda S, Ogawa H.
  • Organizer: International Investigative Dermatology
  • Int'l Joint Research
• [Presentation] AMP-IBP5, an antimicrobial peptide derived from insulin-like growth factor-binding protein 5, triggers human keratinocyte activation. (2018)
  • Author(s): 28.Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H
  • Organizer: International Investigative Dermatology
  • Int'l Joint Research
• [Presentation] A novel antimicrobial (host defense) peptide AMP-IBP5 activates human keratinocytes (2018)
  • Author(s): 29.Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H
  • Organizer: 5th Eastern Asia Dermatology Congress
  • Int'l Joint Research
• [Presentation] A virulence factor of Candida albicans, Candidalysin, modulates human keratinocyte functions. (2018)
  • Author(s): 30.Song P, Niyonsaba F, Okumura K, Ikeda S, Ogawa H
  • Organizer: 5th Eastern Asia Dermatology Congress
  • Int'l Joint Research
• [Presentation] Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-kB-sensitive pathways (2017)
  • Author(s): Yanashima K, Chieosilapatham P, Okumura K, Ogawa H, Niyonsaba F
  • Organizer: The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Synthetic host defense peptide IDR-1018 activates various functions of human mast cells (2017)
  • Author(s): Yanashima K, Chieosilapatham P, Okumura K, Ogawa H, Niyonsaba F
  • Organizer: The 46th Annual Meeting of the Japanese Society for Immunology
• [Presentation] Enhancement of allergic degranulation via the P2Y receptor in mast cells (2017)
  • Author(s): Nishi H, Niyonsaba F
  • Organizer: The 90th Annual Meeting of the Japanese Pharmacological Society
• [Book] Comorbidities in atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment (2020)
  • Author(s): Kiatsurayanon C, Niyonsaba F
  • Total Pages: 265
  • Publisher: Nova Science Publishers, New York
• [Book] Emerging therapies for atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment (2020)
  • Author(s): Peng G, Niyonsaba F
  • Total Pages: 265
  • Publisher: Nova Science Publishers, New York
• [Book] 抗菌ペプチドの機能解明と技術利用 (2017)
  • Author(s): ニヨンサバ フランソワ（ 長岡 功 監修）
  • Publisher: シーエムシー出版
  • ISBN: 9784781312453