| Project/Area Number |
17K10260
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 免疫再構築症候群 / サイトメガロウイルス / サイトカイン / 自然リンパ球 / 重症薬疹 / ウイルス再活性化 |
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| Outline of Final Research Achievements |
We investigated the involvement of human herpesvirus group reactivation in GVHD patients with nonspecific skin eruption, and focused on cytomegalovirus reactivation in skin pathogenesis during immune reconstitution syndrome. We succeeded in obtaining the basic data that TNF-a, IL-6, and IL-17 were elevated in the skin lesions of GVHD patients, and as a result, M1 macrophages proliferated and enhanced the inflammatory response. Also, as a mouse GVHD model, bone marrow transplanted mice in which bone marrow cells and splenocytes are administered to atypical mice have been conventionally used, but a new model succeeded in establishing a system for confirming weight loss and appearance of skin symptoms.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、多くの医師が日常診療において治療に難渋する免疫再構築症候群に注目し、ウイルス再活性化時の病態形成の機序の解明を臨床患者検体とマウスIRSモデルを用いて行ったことを特色とする。様々な免疫状態を引き起こした重症な全身状態を呈する患者に接する可能性が予想される実臨床において、GVHDの患者におけるTNFa、IL-6、IL-17などが治療ターゲットのサイトカインとして明らかとなり、マウスモデルを用いた皮膚病態の解明を継続することで新たな治療戦略の起点となる可能性も含んでいるものと考えている。
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