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MR imaging of energy metabolism: Technical development and applications to brain tumor

Research Project

Project/Area Number 17K10368
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKagoshima University

Principal Investigator

Yoshiura Takashi  鹿児島大学, 医歯学域医学系, 教授 (40322747)

Co-Investigator(Kenkyū-buntansha) 平野 宏文  鹿児島大学, 医歯学総合研究科, 客員研究員 (00264416)
上村 清央  鹿児島大学, 医歯学域鹿児島大学病院, 講師 (30593652)
熊澤 誠志  北海道科学大学, 保健医療学部, 教授 (50363354)
中條 正典  鹿児島大学, 鹿児島大学病院, 特任助教 (60727171)
米澤 大  鹿児島大学, 医歯学域鹿児島大学病院, 助教 (50550076)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsMRI / 脳腫瘍 / CEST / 分子イメージング / 画像診断 / クレアチン / APT / MRI
Outline of Final Research Achievements

Chemical exchange saturation transfer (CEST) is a novel MR imaging contrast. CEST signals at around 2.0 ppm is considered to reflect amine protons among which creatine is the most dominant generator. Creatine is known to be related cellular energy metabolism. To identify creatine-related CEST signals in brain tumors, and to clarify its usefulness in diagnosing brain tumors, we compared CEST signals between high-grade gliomas (HGG) and low-grade gliomas (LGG). Results have shown that there exist significant differences in CEST signal intensity between HGG and LGG at broad offset frequencies including 2.0 ppm, which is specific to proton of amines such as creatine. In addition, it was suggested that the CEST signal at around 2.0 ppm is useful in differentiating benign from malignant gliomas.

Academic Significance and Societal Importance of the Research Achievements

Chemical exchange saturation transfer(CEST)は新たなMRIとして研究されつつある。本研究により、悪性神経膠腫と良性神経膠腫の間に、腫瘍のエネルギー代謝に関連するとされるクレアチンを反映すると考えられる2.0ppm付近のCEST信号の違いが存在し、これが脳腫瘍診断の新たな指標になり得ることが示された。脳腫瘍、特に神経膠腫は非常に難治な疾患であるが、この画像法により腫瘍の悪性度や治療への反応性、予後などを治療前に推定できれば、適切な治療法の選択、ひいては予後の改善につながることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results) Presentation (17 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results)

  • [Journal Article] Histological Grade of Meningioma: Prediction by Intravoxel Incoherent Motion Histogram Parameters2020

    • Author(s)
      Manisha Bohara, Masanori Nakajo, Kiyohisa Kamimura, Tomohide Yoneyama, Yoshihiko Fukukura, Yutaro Kiyao, Hajime Yonezawa, Nayuta Higa, Mari Kirishima, Takashi Yoshiura
    • Journal Title

      Academic Radiology

      Volume: 27 Issue: 3 Pages: 342-353

    • DOI

      10.1016/j.acra.2019.04.012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of microvessel perfusion of pituitary adenomas: a feasibility study using turbo spin-echo-based intravoxel incoherent motion imaging2020

    • Author(s)
      Kiyohisa Kamimura, Masanori Nakajo, Tomohide Yoneyama, Yoshihiko Fukukura, Shingo Fujio, Yuko Goto, Takashi Iwanaga, Yuta Akamine, Takashi Yoshiura
    • Journal Title

      European Radiology

      Volume: 30 Issue: 4 Pages: 1908-1917

    • DOI

      10.1007/s00330-019-06443-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative pharmacokinetic analysis of high-temporal-resolution dynamic contrast-enhanced MRI to differentiate the normal-appearing pituitary gland from pituitary macroadenoma2020

    • Author(s)
      Kiyohisa Kamimura, Masanori Nakajo, Tomohide Yoneyama, Manisha Bohara, Ryota Nakanosono, Shingo Fujio, Takashi Iwanaga, Marcel D Nickel, Hiroshi Imai, Yoshihiko Fukukura, Takashi Yoshiura
    • Journal Title

      Japanese Journal of Radiology

      Volume: - Issue: 7 Pages: 649-657

    • DOI

      10.1007/s11604-020-00942-4

    • NAID

      50014557878

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Amide Proton Transfer Imaging of Cavernous Malformation in the Cavernous Sinus2019

    • Author(s)
      Bohara M, Kamimura K, Nakajo M, Yoneyama T, Yoshiura T
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 18 Issue: 2 Pages: 109-110

    • DOI

      10.2463/mrms.ci.2017-0160

    • NAID

      130007630064

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histogram analysis of amide proton transfer?weighted imaging: comparison of glioblastoma and solitary brain metastasis in enhancing tumors and peritumoral regions2018

    • Author(s)
      Kamimura Kiyohisa、Nakajo Masanori、Yoneyama Tomohide、Fukukura Yoshihiko、Hirano Hirofumi、Goto Yuko、Sasaki Masashi、Akamine Yuta、Keupp Jochen、Yoshiura Takashi
    • Journal Title

      European Radiology

      Volume: - Issue: 8 Pages: 4133-4140

    • DOI

      10.1007/s00330-018-5832-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Amide proton transfer imaging of tumors: theory, clinical applications, pitfalls, and future directions2018

    • Author(s)
      Kamimura Kiyohisa、Nakajo Masanori、Yoneyama Tomohide、Takumi Koji、Kumagae Yuichi、Fukukura Yoshihiko、Yoshiura Takashi
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Issue: 2 Pages: 109-116

    • DOI

      10.1007/s11604-018-0787-3

    • NAID

      210000187116

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] APTイメージング 基礎から臨床まで2019

    • Author(s)
      吉浦 敬
    • Organizer
      宮崎県放射線科医会 宮崎県画像医学研究会 合同学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Amide proton transfer in high grade glioma: Correlation with apparent diffusion coefficient, relative cerebral blood volume and permeability imaging parameters2019

    • Author(s)
      Nakajo M, Kamimura K, Yoneyama T, Iwanaga T, Akamine Y, Fukukura Y, Yoshiura T
    • Organizer
      ISMRM 27th Annual Meeting & Exhibition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 耳から入るAPTイメージング 造影MRIとの比較を含め2019

    • Author(s)
      吉浦 敬
    • Organizer
      耳学問の会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CEST・APTイメージングの臨床応用2019

    • Author(s)
      吉浦 敬
    • Organizer
      先端総合イメージングセミナー2020
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Histogram analysis of amide proton transfer-weighted imaging: comparing glioblastoma and metastatic brain tumor in enhancing tumors and peritumoral regions2018

    • Author(s)
      Kamimura K, Nakajo M, Yoneyama T, Hirano H, Iwanaga T, Akamine Y, Keupp J, Yoshiura T
    • Organizer
      The 77th Annual Meeting of the Japan Radiological Society
    • Related Report
      2018 Research-status Report
  • [Presentation] Feasibility of amide proton transfer MR imaging and diffusion weighted MR imaging for differentiation between glioblastomas and primary central nervous system lymphomas2018

    • Author(s)
      Nakajo M, Kamimura K, Yoneyama T, Iwanaga T, Akamine Y, Keupp J, Yoshiura T
    • Organizer
      The 77th Annual Meeting of the Japan Radiological Society
    • Related Report
      2018 Research-status Report
  • [Presentation] Amide proton transfer-weighted imaging of glioblastoma and metastatic brain tumor: histogram analysis in enhancing tumors and peritumoral regions2018

    • Author(s)
      Kamimura K, Nakajo M, Yoneyama T, Hirano H, Iwanaga T, Akamine Y, Keupp J, Yoshiura T
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高悪性度神経膠腫のAPT信号:ADCおよびrCBVとの相関2018

    • Author(s)
      中條正典、米山知秀、上村清央、岩永崇、平野宏文、吉浦敬
    • Organizer
      第187回日本医学放射線学会九州地方会
    • Related Report
      2018 Research-status Report
  • [Presentation] Amide proton transfer in high grade glioma: Correlation with apparent diffusion coefficient, relative cerebral blood volume and permeability imaging parameters2018

    • Author(s)
      Nakajo M, Kamimura K, Yoneyama T, Hirano H, Iwanaga T, Akamine Y, Fukukura Y, Yoshiura T
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine
    • Related Report
      2018 Research-status Report
  • [Presentation] Amide proton transfer imaging for rectal cancer: correlation with IVIM and DCE MRI, and 18F-FDG-PET/CT2018

    • Author(s)
      Kumagae Y, Fukukura Y, Hakamada H, Nagano H, Akamine Y, Yoshiura T
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine
    • Related Report
      2018 Research-status Report
  • [Presentation] Amide Proton Transfer Imaging in the Head and Neck: A Feasibility Study for Differentiating Malignant from Benign Lesions2018

    • Author(s)
      Takumi K, Hakamada H, Nagano H, Fukukura Y, Keupp J, Sung E, Sakai O, Yoshiura T
    • Organizer
      RSNA 104th Scientific Assembly and Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] APT強調像による血管芽腫と転移性脳腫瘍の比較2018

    • Author(s)
      上村清央、中條正典、米山知秀、平野宏文、佐々木雅史、Jochen Keupp、赤嶺雄太、吉浦敬
    • Organizer
      第47回日本神経放射線学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Feasibility of Amide Proton Transfer Imaging in Head and Neck Lesions: A Preliminary Study2018

    • Author(s)
      Takumi K, Hakamada H, Fukukura Y, Kumagae Y, Keupp J, Yoshiura T
    • Organizer
      Asian Oceanian Congress of Radiology 2018/Symposium Neuroradiologicum XXI
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 転移性脳腫瘍における腫瘍および腫瘍周囲T2延長域のAPT強調像の検討2017

    • Author(s)
      上村清央、中條正典、米山知秀、平野宏文、岩永崇、奥秋知幸、Jochen Keupp、吉浦敬
    • Organizer
      第185回日本医学放射線学会九州地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] Feasibility of amide proton transfer imaging for diagnosing malignant from benign lesions in the head and neck2017

    • Author(s)
      K Takumi, H Hakamada, Y Fukukura, Y Kumagae, J. Keupp, T Okuaki, T Yoshiura
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
  • [Presentation] Amide proton transfer imaging: comparing glioblastoma and metastatic brain tumor in enhancing tumors and peritumoral regions2017

    • Author(s)
      Kamimura K, Nakajo M, Yoneyama T, Iwanaga T, Keupp J, Okuaki T, Yoshiura T
    • Organizer
      RSNA 103rd Scientific Assembly and Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] APT imaging of tumors: Theory, clinical applications, pitfalls and future directions2017

    • Author(s)
      Kamimura K, Nakajo M, Takumi K, Kumagae Y, Yoneyama T, Yoshiura T
    • Organizer
      RSNA 103rd Scientific Assembly and Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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