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Dual-energy computed tomography for non-invasive staging of liver fibrosis: Accuracy of iodine density measurements from contrast-enhanced data.

Research Project

Project/Area Number 17K10379
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKindai University

Principal Investigator

Tsurusaki Masakatsu  近畿大学, 医学部, 教授 (00379356)

Co-Investigator(Kenkyū-buntansha) 村上 卓道  神戸大学, 医学研究科, 教授 (20252653)
兵頭 朋子  近畿大学, 医学部, 講師 (40403836)
祖父江 慶太郎  神戸大学, 医学部附属病院, 講師 (90622027)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsCT / DECT / 放射線医学 / ヨード造影剤 / 肝線維化 / X線 / 肝臓 / 線維化 / エックス線 / CT / 肝硬変
Outline of Final Research Achievements

We have shown that iodine map imaging using the Dual Energy CT material fractionation technology developed in collaboration with GE of the United States can be used to measure the degree of liver fibrosis in chronic hepatitis. The ΔLiver/Aorta index correlated well with fibrosis, indicating the possibility of substituting invasive liver biopsy for fibrosis determination using routine contrast-enhanced dynamic CT, in addition to conventional MRI and US elastography. The results showed the possibility of substituting invasive liver biopsy for fibrosis determination using routine contrast-enhanced dynamic CT in addition to conventional MRI and US elastography.

Academic Significance and Societal Importance of the Research Achievements

1. ウイルス性肝炎において肝線維化の非侵襲的な評価が可能になる.
現在,肝線維化診断には肝生検が必須であるが,CTというさらに簡便で侵襲の少ない検査法での評価が可能となることで,抗ウイルス治療前後など繰り返しの評価が簡便に行えるようになる.2. 客観性が高く,導入が容易である.
造影剤の肝への取り込みを絶対値であるヨード密度で定量・数値化するため,より客観性の高い測定ができる.また日常的に臨床使用されている造影CTの際に測定できる画像を用いるため新たな機器やソフトウェアの購入,特殊な条件設定が不要である上に再現性も高い

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2021 2020 2019 2018 2017

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 8 results) Book (2 results)

  • [Journal Article] Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications2021

    • Author(s)
      Tsurusaki Masakatsu、Sofue Keitaro、Hori Masatoshi、Sasaki Kosuke、Ishii Kazunari、Murakami Takamichi、Kudo Masatoshi
    • Journal Title

      Diagnostics

      Volume: 11 Issue: 2 Pages: 161-161

    • DOI

      10.3390/diagnostics11020161

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcatheter Arterial Embolization Treatment for Bleeding Visceral Artery Pseudoaneurysms in Patients with Pancreatitis or Following Pancreatic Surgery.2021

    • Author(s)
      Numoto I, Tsurusaki M, Oda T, Yagyu Y, Ishii K, Murakami T.
    • Journal Title

      Cancers (Basel).

      Volume: 12 Issue: 10 Pages: 2733-2733

    • DOI

      10.3390/cancers12102733

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Higher enhancement intrahepatic nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-enhanced MRI as a Poor Responsive Marker of Anti-PD-1 / PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma.2021

    • Author(s)
      Aoki T, Nishida N, Ueshima K, Morita M, Chishina H, Takita M, Hagiwara S, Ida H, Minami Y, Yamada A, Sofue K, Tsurusaki M, Kudo M.
    • Journal Title

      Liver cancer

      Volume: 10 Issue: 6 Pages: 615-628

    • DOI

      10.1159/000518048

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-Dimensional Radiological Assessment of Ablative Margins in Hepatocellular Carcinoma: Pilot Study of Overlay Fused CT/MRI Imaging with Automatic Registration2021

    • Author(s)
      Minami Yasunori、Minami Tomohiro、Ueshima Kazuomi、Yagyu Yukinobu、Tsurusaki Masakatsu、Okada Takuya、Hori Masatoshi、Kudo Masatoshi、Murakami Takamichi
    • Journal Title

      Cancers

      Volume: 13 Issue: 6 Pages: 1460-1460

    • DOI

      10.3390/cancers13061460

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-Operative Imaging and Pathological Diagnosis of Localized High-Grade Pancreatic Intra-Epithelial Neoplasia without Invasive Carcinoma.2021

    • Author(s)
      Sagami R, Yamao K, Nakahodo J, Minami R, Tsurusaki M, Murakami K, Amano Y.
    • Journal Title

      Cancers (Basel).

      Volume: 13 Issue: 5 Pages: 945-945

    • DOI

      10.3390/cancers13050945

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of respiratory-gated PET acquisition during delayed 18F-FDG PET/CT scanning for patients with liver metastases.2021

    • Author(s)
      Watanabe S, Hanaoka K, Kaida H, Hyodo T, Yamada M, Tsurusaki M, Ishii K.
    • Journal Title

      Asia Ocean J Nucl Med Biol.

      Volume: 9 Pages: 12-149

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploratory Analysis of Lenvatinib Therapy in Patients with Unresectable Hepatocellular Carcinoma Who Have Failed Prior PD-1/PD-L1 Checkpoint Blockade.2021

    • Author(s)
      Aoki T, Kudo M, Ueshima K, Morita M, Chishina H, Takita M, Hagiwara S, Ida H, Minami Y, Tsurusaki M, Nishida N.
    • Journal Title

      Cancers (Basel).

      Volume: 12 Issue: 10 Pages: 3048-3048

    • DOI

      10.3390/cancers12103048

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive factors of truncation artifacts in the arterial phase of Gd-EOB-DTPA-enhanced MRI: a nationwide multicenter study2020

    • Author(s)
      Tsurusaki Masakatsu、Sofue Keitaro、Onishi Hiromitsu、Goshima Satoshi、Higaki Atsushi、Isoda Hiroyoshi、Haradome Hiroki、Ishii Kazunari、Murakami Takamichi
    • Journal Title

      Japanese Journal of Radiology

      Volume: 39 Issue: 2 Pages: 165-177

    • DOI

      10.1007/s11604-020-01052-x

    • NAID

      210000163644

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of Liver Metastases Using CT and MRI Scans in Patients with Pancreatic Ductal Adenocarcinoma: Effects of Observer Experience on Diagnostic Accuracy2020

    • Author(s)
      Tsurusaki M, Numoto I, Oda T, Wakana M, Suzuki A, Yagyu Y, Matsuki M, Ishii K.
    • Journal Title

      Cancers (Basel)

      Volume: 12 Issue: 6 Pages: 1455-1455

    • DOI

      10.3390/cancers12061455

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dual-frequency MR elastography to differentiate between inflammation and fibrosis of the liver: Comparison with histopathology.2020

    • Author(s)
      Sofue K, Onoda M, Tsurusaki M, Morimoto D, Yada N, Kudo M, Murakami T.
    • Journal Title

      J Magn Reson Imaging.

      Volume: 51 Issue: 4 Pages: 1053-1064

    • DOI

      10.1002/jmri.26903

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The technical aspects of a feasible new technique for ipsilateral percutaneous transhepatic portal vein embolization.2019

    • Author(s)
      Tsurusaki M, Oda T, Sofue K, Numoto I, Yagyu Y, Kashiwagi N, Murakami T.
    • Journal Title

      Br J Radiol.

      Volume: 91 Issue: 1092 Pages: 20180382-20180382

    • DOI

      10.1259/bjr.20180124

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual-energy computed tomography for non-invasive staging of liver fibrosis: Accuracy of iodine density measurements from contrast-enhanced data.2018

    • Author(s)
      Sofue K, Tsurusaki M, Mileto A, Hyodo T, Sasaki K, Nishi T, Chikugo T, Yada N, Kudo M, Sugimura K, Murakami T
    • Journal Title

      Hepatol Res

      Volume: 48(12) Issue: 12 Pages: 1008-1019

    • DOI

      10.1111/hepr.13205

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Magnetic resonance elastography in the assessment of hepatic fibrosis: a study comparing transient elastography and histological data in the same patients.2017

    • Author(s)
      Toguchi M, Tsurusaki M, Yada N, Sofue K, Hyodo T, Onoda M, Numoto I, Matsuki M, Imaoka I, Kudo M, Murakami T.
    • Journal Title

      Abdom Radiol

      Volume: 42 Issue: 6 Pages: 1659-1666

    • DOI

      10.1007/s00261-017-1045-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Book] Multislice CT, Fourth Edition2019

    • Author(s)
      Sofue K, Tsurusaki M, Murakami T.
    • Total Pages
      12
    • Publisher
      Springer Nature Switzerland AG
    • ISBN
      3319425862
    • Related Report
      2019 Research-status Report
  • [Book] Cirrhotic Liver. Medical Radiology.2019

    • Author(s)
      Sofue K., Tsurusaki M., Murakami T.
    • Total Pages
      10
    • Publisher
      Springer, Berlin
    • Related Report
      2019 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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