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Development and evaluation of an algorithm to analyze the heterogeneity of molecular images

Research Project

Project/Area Number 17K10445
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

SASAKI MASAYUKI  九州大学, 医学研究院, 教授 (40240907)

Co-Investigator(Kenkyū-buntansha) 藪内 英剛  九州大学, 医学研究院, 教授 (70380623)
有村 秀孝  九州大学, 医学研究院, 教授 (20287353)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords分子イメージング / 不均一性 / PET / SPECT / テクスチャ解析 / radiomics / PET / 腫瘍 / 核医学
Outline of Final Research Achievements

In this study, an algorithm to analyze the heterogeneity of molecular images was developed. In phantom studies, the smoothing filter for image reconstruction affected the results to varying degrees between features. Body movements also affected the results. In a clinical study, some features of regional type analysis were useful for differentiating between Parkinson disease and diffuse Levy body disease. Based on these results, radiomics analysis was considered to be useful for the evaluation of the heterogeneity of molecular imaging reflecting the pathophysiological feature of neurodegenerative disorders. However, the standardization of the technology was suggested to be highly important to make the molecular imaging to be a reliable biomarker.

Academic Significance and Societal Importance of the Research Achievements

本研究の特色は遺伝子変化に起因する腫瘍不均一性を、分子イメージングによって非侵襲的に評価する方法を確立することにある。分子イメージングを世界共通のバイオマーカーとするには、検査方法の標準化が重要であることが明らかとなった。また、分子イメージングの不均一性評価は、病理組織学的特徴の数値化の可能性とともにテーラーメイドの個別化医療の推進に寄与すると期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017

All Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] The usefulness of texture analysis analyzing heterogeneous uptake on DaT SPECT images for the differential diagnosis2019

    • Author(s)
      Aya Takashima, Natsumi Shimokawa, Yuji Tsutsui, Shingo Baba, Masayuki Sasaki
    • Organizer
      第75回 日本放射線技術学会総会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳ドパミントランスポータSPECTによる鑑別診断におけるradiomics解析の有用性の検討2019

    • Author(s)
      高島彩、下川夏実、勝部俊、椿悠馬、筒井悠治、馬場眞吾、佐々木雅之
    • Organizer
      第39回 日本核医学技術学会総会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Influence of respiratory motion on radiomics analyses of intratumoral heterogeneity in PET/CT imaging2018

    • Author(s)
      Toshiki Takeshita, Taiki Magome, Keishin Morita, Yuji Tsutsui, Kazuhiko Himuro, Shingo Baba, Masayuki Sasaki
    • Organizer
      第74回 日本放射線技術学会総会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Influence of a Gaussian filter on the evaluation of the PET heterogeneity2018

    • Author(s)
      Ayano Shoji, Keishin Morita, Toshiki Takeshita, Yuji Tsutsui, Kazuhiko Himuro, Shingo Baba, Masayuki Sasaki
    • Organizer
      第74回 日本放射線技術学会総会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] A Gaussian filter influenced the evaluation of heterogeneity on PET images2018

    • Author(s)
      Ayano Shoji, Keishin Morita, Toshiki Takeshita, Naoki Hashimoto, Saki Kimoto, Yuji Tsutsui, Kazuhiko Himuro, Shingo Baba, Masayuki Sasaki
    • Organizer
      65th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
    • Related Report
      2018 Research-status Report
  • [Presentation] ヒートマップを用いたPET不均一集積とテクスチャー特徴量の関係2018

    • Author(s)
      庄司彩乃、守田圭伸、橋本直樹、竹下利貴、木本沙希、筒井悠治、氷室和彦、馬場眞吾、佐々木雅之
    • Organizer
      第38回日本核医学技術会総会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] The influence of a post filter for evaluating heterogeneity on PET images2017

    • Author(s)
      Ayano Shoji, Keishin Morita, Toshiki Takeshita, Go Akamatsu, Akira Maebatake, Yuji Tsutsui, Kazuhiko Himuro, Shingo Baba, Masayuki Sasaki
    • Organizer
      64th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The characteristics of parameters in texture analysis for evaluating heterogeneity2017

    • Author(s)
      Ayano Shoji, Keishin Morita, Naoki Hashimoto, Yuji Tsutsui, Kazuhiko Himuro, Shingo Baba, Masayuki Sasaki
    • Organizer
      第37回日本核医学技術会総会学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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